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1.2.5.1: pyruvate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase (quinone), go to the full flat file.

Wordmap for 1.2.5.1

Word Map on EC 1.2.5.1 Wordmap for 1.2.5.1

Reaction

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pyruvate
+
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ubiquinone
+
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H2O
=
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acetate
+
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CO2
+
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ubiquinol

Synonyms

EC 1.2.2.2, ECPOX, POX, poxB, POXEC, pqo, pyruvate (quinone) dehydrogenase, pyruvate oxidase, pyruvate oxidase B, pyruvate:quinone oxidoreductase, pyruvate:ubiquinone-8-oxidoreductase, ubiquinione-dependent pyruvate oxidase, ubiquinone-dependent pyruvate oxidase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.5 With a quinone or similar compound as acceptor
                EC 1.2.5.11.2.5.1 pyruvate dehydrogenase (quinone)

Metals Ions

Metals Ions on EC 1.2.5.1 - pyruvate dehydrogenase (quinone)

for references in articles please use BRENDA:EC1.2.5.1

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha-chymotrypsin
-
20 micromol/ml, wild-type enzyme and the mutant poxB4 are activated 15- and 70fold, respectively, and the mutant poxB3 is activated 14fold
anionic detergents
-
the enzyme activity is stimulated 20- to 50fold, if the enzyme is removed from the membrane particulate fraction of the cell by incubation with a wide variety of amphiphiles
Cationic detergents
-
the enzyme activity is stimulated 20- to 50fold, if the enzyme is removed from the membrane particulate fraction of the cell by incubation with a wide variety of amphiphiles
Mg2+
-
as cofactor
Mn2+
-
divalent metal ion required
SDS
-
20 microM, activates the wild-type and mutant enzymes, poxB3 and poxB4, 15-, 20-, and 70fold, respectively
Triton X-100
-
2.2 mM, activates the wild-type and mutant enzymes, poxB3 and poxB4, 32-, 4-, and 6fold, respectively. With the addition of alpha-chymotrypsin the activation of the mutant enzymes poxB3 and poxB4 is increased 14- and 39fold, respectively
Zwitterionic detergents
-
the enzyme activity is stimulated 20- to 50fold, if the enzyme is removed from the membrane particulate fraction of the cell by incubation with a wide variety of amphiphiles