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Information on EC 1.2.5.1 - pyruvate dehydrogenase (quinone)

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IUBMB Comments
Flavoprotein (FAD) . This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate . The enzyme can also form acetoin .
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The enzyme appears in viruses and cellular organisms
Synonyms
pyruvate:quinone oxidoreductase, poxec, pyruvate oxidase b, ubiquinone-dependent pyruvate oxidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol
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