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1.2.5.1: pyruvate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase (quinone), go to the full flat file.

Wordmap for 1.2.5.1

Word Map on EC 1.2.5.1 Wordmap for 1.2.5.1

Reaction

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pyruvate
+
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ubiquinone
+
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H2O
=
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acetate
+
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CO2
+
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ubiquinol

Synonyms

EC 1.2.2.2, ECPOX, POX, poxB, POXEC, pqo, pyruvate (quinone) dehydrogenase, pyruvate oxidase, pyruvate oxidase B, pyruvate:quinone oxidoreductase, pyruvate:ubiquinone-8-oxidoreductase, ubiquinione-dependent pyruvate oxidase, ubiquinone-dependent pyruvate oxidase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.5 With a quinone or similar compound as acceptor
                EC 1.2.5.11.2.5.1 pyruvate dehydrogenase (quinone)

Activating Compound

Activating Compound on EC 1.2.5.1 - pyruvate dehydrogenase (quinone)

for references in articles please use BRENDA:EC1.2.5.1

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cis-12-hydroxy-9-octadecenoic acid
-
119% of the activitation with palmitic acid
elaidic acid
-
122% of the activitation with palmitic acid
lauric acid
lecithin
-
the hydrophobic moieties of lecithin activate pyruvate oxidase whereas the hydrophilic portions of the molecule have no stimulatory effect
linoleic acid
-
116% of the activitation with palmitic acid
linolelaidic acid
-
113% of the activitation with palmitic acid
linolenic acid
-
126% of the activitation with palmitic acid
Lipids
-
enzyme is activated by lipids, high affinity binding site
-
lysophosphatidylethanolamine
-
highest stimulating activity among the phospholipid extracted from cell membranes tested, if the phospholipids are added directly to the assay mixtures. When water-soluble micellar preparations are substituted for direct addition of the phospholipid to the assay, all the phosphatides demonstrate higher specific activities for stimulating pyruvate oxidase, and the differences in their stimulating capacity are minimized
myristic acid
-
109% of the activitation with palmitic acid
n-nonanoic acid
-
42% of the activitation with palmitic acid
oleic acid
palmitic acid
palmitoleic acid
-
137% of the activitation with palmitic acid
trans-12-hydroxy-9-octadecenoic acid
-
103% of the activitation with palmitic acid
additional information
-