1.2.1.11: aspartate-semialdehyde dehydrogenase This is an abbreviated version! For detailed information about aspartate-semialdehyde dehydrogenase, go to the full flat file .
Reaction
L-aspartate 4-semialdehyde +
phosphate +
NADP+ =
L-4-aspartyl phosphate +
NADPH +
H+
Synonyms AFUA_3G06830, ASA dehydrogenase, ASA DH, ASA-DH, ASADH, ASADHD, Asd, ASD enzyme, Asd1, Asd2, AsdA, aspartate beta-semialdehyde dehydrogenase, aspartate semialdehyde dehydrogenase, aspartate-beta-semialdehyde dehydrogenase, aspartate-beta-semialdeyhyde dehydrogenase, aspartate-semialdehyde dehydrogenase, aspartic acid semialdehyde dehydrogenase, aspartic beta-semialdehyde dehydrogenase, aspartic semialdehyde dehydrogenase, aspartyl beta-semialdehyde dehydrogenase, aspartyl semialdehyde dehydrogenase, BDCG_01946, CNA02450, dehydrogenase, aspartate semialdehyde, ecASADH, FtASADH, hiASADH, L-aspartate-beta-semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosphorylating), Rv3708c
ECTree
Application
Application on EC 1.2.1.11 - aspartate-semialdehyde dehydrogenase
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synthesis
the modofied enzyme with altered substrate specificity using NAD(H) is preferred in biotechnological production of amino acids due to lower costs and higher stability
biotechnology
-
development of lysine-overproducing strains
biotechnology
the modofied enzyme with altered substrate specificity using NAD(H) is preferred in biotechnological production of amino acids due to lower costs and higher stability
biotechnology
-
development of lysine-overproducing strains
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drug development
-
ASADH is a target for the development of novel antibiotics, especially for Gram-negative bacteria that require diaminopimelate for cell-wall biosynthesis
drug development
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ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action
drug development
-
ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action
drug development
the enzyme is a validated target for antimicrobial drug design
drug development
the enzyme is a validated target for antimicrobial drug design
drug development
-
the enzyme is a validated target for antimicrobial drug design
-
drug development
-
the enzyme is a validated target for antimicrobial drug design
-
medicine
enzyme is a validated drug target
medicine
enzyme is potential target for antimicrobial drugs
medicine
-
target for antibiotic development
medicine
-
target for antibiotic development
medicine
-
enzyme is a validated drug target
-
pharmacology
enzyme is a target for development of antibiotics
pharmacology
inhibitor design from enzyme three-dimensional structure
pharmacology
-
inhibitor design from enzyme three-dimensional structure
-
additional information
enzyme is an attractive target for development of antibacterial, fungicidal, or herbicidal compounds
additional information
-
enzyme is an attractive target for development of antibacterial, fungicidal, or herbicidal compounds