Literature summary for 1.2.1.11 extracted from

Carroll, A.R.; Ngo, A.; Quinn, R.J.; Redburn, J.; Hooper, J.N.
Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp (2005), J. Nat. Prod., 68, 804-806.

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Application

Application	Comment	Organism
medicine	target for antibiotic development	Helicobacter pylori

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Helicobacter pylori

Inhibitors

Inhibitors	Comment	Organism	Structure
petrosamine B	50% inhibition at 0.306 mM. Petrosamine B is a pyridoacridine alkaloid isolated from the sponge Oceanapia sp.; isolated from the methanol extract of the saustralian sponge Oceanapia sp.	Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+	Helicobacter pylori	-	L-4-aspartyl phosphate + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-affinity chromatography	Helicobacter pylori

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Helicobacter pylori	L-4-aspartyl phosphate + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
Asd	-	Helicobacter pylori
aspartate semialdehyde dehydrogenase	-	Helicobacter pylori
aspartate-semialdehyde dehydrogenase	-	Helicobacter pylori
aspartyl semialdehyde dehydrogenase	-	Helicobacter pylori

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
23	-	activity assay	Helicobacter pylori

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	activity assay	Helicobacter pylori

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Helicobacter pylori
NADPH	-	Helicobacter pylori

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.306	-	-	Helicobacter pylori	petrosamine B

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Release 2023.1 (January 2023)