Application | Comment | Organism |
---|---|---|
drug development | ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action | Streptococcus pneumoniae |
drug development | ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action | Vibrio cholerae serotype O1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | - |
Streptococcus pneumoniae | |
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | - |
Vibrio cholerae serotype O1 | |
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | - |
Streptococcus pneumoniae | |
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | - |
Vibrio cholerae serotype O1 | |
additional information | the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview | Streptococcus pneumoniae | |
additional information | the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview. No inhibition by 4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid, N-(4-bromobenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine , and N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | Vibrio cholerae serotype O1 | |
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-carboxyethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-carboxyethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 | |
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Streptococcus pneumoniae | |
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine | - |
Vibrio cholerae serotype O1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + phosphate + NADP+ | Streptococcus pneumoniae | - |
L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | Vibrio cholerae serotype O1 | - |
L-4-aspartyl phosphate + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Vibrio cholerae serotype O1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Streptococcus pneumoniae | L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Vibrio cholerae serotype O1 | L-4-aspartyl phosphate + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ASADH | - |
Streptococcus pneumoniae |
ASADH | - |
Vibrio cholerae serotype O1 |
aspartate-beta-semialdehyde dehydrogenase | - |
Streptococcus pneumoniae |
aspartate-beta-semialdehyde dehydrogenase | - |
Vibrio cholerae serotype O1 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Streptococcus pneumoniae |
22 | - |
assay at room temperature | Vibrio cholerae serotype O1 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.6 | - |
assay at | Streptococcus pneumoniae |
8.6 | - |
assay at | Vibrio cholerae serotype O1 |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Streptococcus pneumoniae | |
NADP+ | - |
Vibrio cholerae serotype O1 | |
NADPH | - |
Streptococcus pneumoniae | |
NADPH | - |
Vibrio cholerae serotype O1 |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.012 | - |
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.016 | - |
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.024 | - |
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.036 | - |
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.054 | - |
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.057 | - |
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.063 | - |
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.072 | - |
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.176 | - |
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.22 | - |
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.229 | - |
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.246 | - |
N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.276 | - |
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.296 | - |
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.296 | - |
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.297 | - |
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.303 | - |
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.324 | - |
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.329 | - |
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.396 | - |
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.427 | - |
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.43 | - |
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.441 | - |
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.442 | - |
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.476 | - |
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.498 | - |
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.509 | - |
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.524 | - |
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.528 | - |
N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.529 | - |
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.54 | - |
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
0.608 | - |
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.609 | - |
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.628 | - |
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.629 | - |
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.634 | - |
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.635 | - |
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.639 | - |
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.648 | - |
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.649 | - |
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.654 | - |
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.655 | - |
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.663 | - |
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.663 | - |
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.665 | - |
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.675 | - |
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.678 | - |
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.684 | - |
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.69 | - |
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.692 | - |
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.696 | - |
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.698 | - |
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.708 | - |
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.721 | - |
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.724 | - |
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.727 | - |
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.737 | - |
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
0.749 | - |
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
1.1 | - |
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Vibrio cholerae serotype O1 | |
2.4 | - |
N-carboxyethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
3.6 | - |
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae | |
3.8 | - |
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine | pH 8.6, 22°C | Streptococcus pneumoniae |
General Information | Comment | Organism |
---|---|---|
evolution | the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening | Streptococcus pneumoniae |
evolution | the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening | Vibrio cholerae serotype O1 |
metabolism | aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals | Streptococcus pneumoniae |
metabolism | aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals | Vibrio cholerae serotype O1 |