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1.14.13.154: erythromycin 12-hydroxylase

This is an abbreviated version!
For detailed information about erythromycin 12-hydroxylase, go to the full flat file.

Wordmap for 1.14.13.154

Word Map on EC 1.14.13.154 Wordmap for 1.14.13.154

Reaction

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erythromycin D
+
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NADPH
+
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H+
+
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O2
=
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erythromycin C
+
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NADP+
+
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H2O

Synonyms

CYP113A1, EryK, erythromycin C-12 hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.13.1541.14.13.154 erythromycin 12-hydroxylase

General Information

General Information on EC 1.14.13.154 - erythromycin 12-hydroxylase

for references in articles please use BRENDA:EC1.14.13.154

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
an Saccharopolyspora erythraea strain disrupted in eryK no longer produces erythromycin A but accumulates the B and D forms of the antibiotic
physiological function
the enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis