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1.14.13.154: erythromycin 12-hydroxylase

This is an abbreviated version!
For detailed information about erythromycin 12-hydroxylase, go to the full flat file.

Wordmap for 1.14.13.154

Word Map on EC 1.14.13.154 Wordmap for 1.14.13.154

Reaction

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erythromycin D
+
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NADPH
+
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H+
+
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O2
=
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erythromycin C
+
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NADP+
+
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H2O

Synonyms

CYP113A1, EryK, erythromycin C-12 hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.13.1541.14.13.154 erythromycin 12-hydroxylase

Systematic Name

Systematic Name on EC 1.14.13.154 - erythromycin 12-hydroxylase

for references in articles please use BRENDA:EC1.14.13.154

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SYSTEMATIC NAME
IUBMB Comments
erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating)
The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B [1].