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1.14.13.154: erythromycin 12-hydroxylase

This is an abbreviated version!
For detailed information about erythromycin 12-hydroxylase, go to the full flat file.

Wordmap for 1.14.13.154

Word Map on EC 1.14.13.154 Wordmap for 1.14.13.154

Reaction

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erythromycin D
+
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NADPH
+
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H+
+
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O2
=
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erythromycin C
+
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NADP+
+
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H2O

Synonyms

CYP113A1, EryK, erythromycin C-12 hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.13.1541.14.13.154 erythromycin 12-hydroxylase

Reference

Reference on EC 1.14.13.154 - erythromycin 12-hydroxylase

for references in articles please use BRENDA:EC1.14.13.154

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, Y.; Deng, W.; Wu, J.; Qian, J.; Chu, J.; Zhuang, Y.; Zhang, S.; Liu, W.
Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation
Appl. Environ. Microbiol.
74
1820-1828
2008
Saccharopolyspora erythraea (P48635)
Manually annotated by BRENDA team
Lambalot, R.H.; Cane, D.E., Aparicio, J.J.; Katz, L.
Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK
Biochemistry
34
1858-1866
1995
Saccharopolyspora erythraea
Manually annotated by BRENDA team
Montemiglio, L.C.; Gianni, S.; Vallone, B.; Savino, C.
Azole drugs trap cytochrome P450 EryK in alternative conformational states
Biochemistry
49
9199-9206
2010
Saccharopolyspora erythraea (P48635)
Manually annotated by BRENDA team
Lee, S.K.; Basnet, D.B.; Choi, C.Y.; Sohng, J.K.; Ahn, J.S.; Yoon, Y.J.
The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis
Bioorg. Chem.
32
549-559
2004
Saccharopolyspora erythraea (P48635), Saccharopolyspora erythraea
Manually annotated by BRENDA team
Stassi, D.; Donadio, S.; Staver, M.J.; Katz, L.
Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis
J. Bacteriol.
175
182-189
1993
Saccharopolyspora erythraea (P48635)
Manually annotated by BRENDA team
Savino, C.; Montemiglio, L.C.; Sciara, G.; Miele, A.E.; Kendrew, S.G.; Jemth, P.; Gianni, S.; Vallone, B.
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate
J. Biol. Chem.
284
29170-29179
2009
Saccharopolyspora erythraea (P48635)
Manually annotated by BRENDA team
Savino, C.; Sciara, G.; Miele, A.E.; Kendrew, S.G., Vallone, B.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of C-12 hydroxylase EryK from Saccharopolyspora erythraea
Protein Pept. Lett.
15
1138-1141
2008
Saccharopolyspora erythraea (P48635), Saccharopolyspora erythraea
Manually annotated by BRENDA team