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1.14.13.154: erythromycin 12-hydroxylase

This is an abbreviated version!
For detailed information about erythromycin 12-hydroxylase, go to the full flat file.

Wordmap for 1.14.13.154

Word Map on EC 1.14.13.154 Wordmap for 1.14.13.154

Reaction

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erythromycin D
+
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NADPH
+
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H+
+
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O2
=
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erythromycin C
+
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NADP+
+
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H2O

Synonyms

CYP113A1, EryK, erythromycin C-12 hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.13.1541.14.13.154 erythromycin 12-hydroxylase

Application

Application on EC 1.14.13.154 - erythromycin 12-hydroxylase

for references in articles please use BRENDA:EC1.14.13.154

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
systematically modulating the enzyme amounts of EryK and EryG by integrating additional eryK and eryG copies into the industrial strain Saccharopolyspora erythraea HL3168 E3 significantly enhances the process of biotransformation from erythromycin-D to erythromycin-A, nearly completely eliminates the by-products erythromycin-B and erythromycin-C, and efficiently improves erythromycin-A production and purity at the fermentation stage. In conjunction with other traditional and genetic ways to continuously evaluate the erythromycin-A production system