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Information on EC 1.14.13.154 - erythromycin 12-hydroxylase

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IUBMB Comments
The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B .
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Word Map
  • 1.14.13.154
  • editing
  • inosine
  • a-to-i
  • deaminases
  • deamination
  • symmetrica
  • hereditaria
  • dyschromatosis
  • rna-editing
  • rna-specific
  • adenosine-to-inosine
  • interferon-inducible
  • ifn-inducible
  • glur-b
  • site-selective
  • zalpha
  • left-handed
  • adar2-mediated
  • hypopigmented
  • dsrbds
  • recoding
  • hyperediting
  • synthesis
  • macules
  • z-dna-binding
  • genodermatosis
  • dsrna-binding
The expected taxonomic range for this enzyme is: Saccharopolyspora erythraea
Synonyms
erythromycin c-12 hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
erythromycin D + NADPH + H+ + O2 = erythromycin C + NADP+ + H2O
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