1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.

Reaction

Synonyms

AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase

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Results	in table
7	Activating Compound
16	AA Sequence
7	Application
26	Cloned(Commentary)
1	Cofactor
7	Crystallization (Commentary)
15	Disease/ Diagnostics
12	Expression
101	General Information
1	General Stability
31	IC50 Value
42	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
30	Localization
15	Metals/Ions
70	Natural Substrates/ Products (Substrates)
86	Organism
2	PDB ID
6	pH Optimum
5	Posttranslational Modification
43	Protein Variants
5	Purification (Commentary)
3	Reaction
51	Reference
46	Source Tissue
114	Substrates and Products (Substrate)
2	Subunits
142	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Turnover Number [1/s]

Expression

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Expression on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

checkpoint kinase Rad53 negatively modulates Rph1 protein level

2 entries

Jmjd2c expression is unaffected by 4-hydroxytamoxifen treatment, while Jmjd2a and Jmjd2b are downregulated

2 entries

KDM4A expression is upregulated in phosphatase and tensin homolog knockout mouse prostate tissue

Mus musculus

Q8BW72

764401

mRNA and protein levels of Jmjd2a are significantly increased in the neurons of mouse undergoing neuropathic pain

Mus musculus

Q8BW72

764639

Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment

2 entries

the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1

2 entries

upon 4-hydroxytamoxifen treatment, Jmjd2a and Jmjd2b become undetectable by Western blot, while expression levels for other Jmjd2 family members are unaltered

2 entries

checkpoint kinase Rad53 negatively modulates Rph1 protein level

Saccharomyces cerevisiae

-

726071

checkpoint kinase Rad53 negatively modulates Rph1 protein level

Saccharomyces cerevisiae BY4742

-

-

Jmjd2c expression is unaffected by 4-hydroxytamoxifen treatment, while Jmjd2a and Jmjd2b are downregulated

Mus musculus

Q8BW72, Q8VCD7, Q91VY5

744785

Jmjd2c expression is unaffected by 4-hydroxytamoxifen treatment, while Jmjd2a and Jmjd2b are downregulated

Mus musculus C57BL/6

-

-

Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment

Saccharomyces cerevisiae

-

726071

Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment

Saccharomyces cerevisiae BY4742

-

-

the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1

Saccharomyces cerevisiae

-

726071

the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1

Saccharomyces cerevisiae BY4742

-

-

upon 4-hydroxytamoxifen treatment, Jmjd2a and Jmjd2b become undetectable by Western blot, while expression levels for other Jmjd2 family members are unaltered

Mus musculus

Q8BW72, Q8VCD7, Q91VY5

744785

upon 4-hydroxytamoxifen treatment, Jmjd2a and Jmjd2b become undetectable by Western blot, while expression levels for other Jmjd2 family members are unaltered

Mus musculus C57BL/6

-

-