1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase This is an abbreviated version! For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file .
Reaction
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 +
2 2-oxoglutarate
+
2 O2
=
a [histone H3]-N6-methyl-L-lysine36 +
2 succinate
+
2 formaldehyde
+
2 CO2
Synonyms AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM
ECTree
Localization
Localization on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase
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isozyme KDM4C is associated with chromatin during mitosis, residue R919 on the proximal Tudor domains of KDM4C is critical for its association with chromatin during mitosis. KDM4C protein is localized to mitotic chromatin from prometaphase to telophase
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Rph1 is associated with a specific chromatin locus. Release of Rph1 from chromatin also required the phosphorylation at S652
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Rph1 is associated with a specific chromatin locus. Release of Rph1 from chromatin also required the phosphorylation at S652
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recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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Rph1 associates with nucleosomes independently of H3 Lys36 methylation
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additional information
while KDM4C is associated with mitotic chromatin, KDM4A-B proteins are excluded from chromatin throughout prometaphase-telophase
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while KDM4C is associated with mitotic chromatin, KDM4A-B proteins are excluded from chromatin throughout prometaphase-telophase
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while KDM4C is associated with mitotic chromatin, KDM4A-B proteins are excluded from chromatin throughout prometaphase-telophase
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additional information
Jmjd2a and Jmjd2c both localize to H3K4me3-positive regions. Recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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additional information
Jmjd2a and Jmjd2c both localize to H3K4me3-positive regions. Recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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additional information
Jmjd2a and Jmjd2c both localize to H3K4me3-positive regions. Recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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additional information
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Jmjd2a and Jmjd2c both localize to H3K4me3-positive regions. Recruitment of the Jmjd2 H3K9/H3K36 demethylases to H3K4me3-marked nucleosomes
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