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1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.69

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine36
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase

General Stability

General Stability on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
the JmjN domain is important in maintaining protein stability and the repressive effect of Rph1
-