1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.69

1.14.11.69

demethylation

demethylases

chromatin

jumonji

trimethylation

fbxl10

polycomb

heterochromatic

hp1a

analysis

medicine

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine36

+ 2 2-oxoglutarate + 2 O2 =

a [histone H3]-N6-methyl-L-lysine36

+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase

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Results	in table
7	Activating Compound
16	AA Sequence
7	Application
26	Cloned(Commentary)
1	Cofactor
7	Crystallization (Commentary)
15	Disease/ Diagnostics
12	Expression
101	General Information
1	General Stability
31	IC50 Value
42	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
30	Localization
15	Metals/Ions
70	Natural Substrates/ Products (Substrates)
86	Organism
2	PDB ID
6	pH Optimum
5	Posttranslational Modification
43	Protein Variants
5	Purification (Commentary)
3	Reaction
51	Reference
46	Source Tissue
114	Substrates and Products (Substrate)
2	Subunits
142	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase

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0.037

2-(2-((chroman-6-ylmethyl)amino)pyrimidin-4-yl)isonicotinic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.003

3-(9-(dimethylamino)-N-hydroxynonanamido)propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.2

3-[hydroxy-[5-[[(1R)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-5-oxo-pentanoyl]amino]propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0703

3-[hydroxy-[5-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-5-oxo-pentanoyl]amino]propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0606

3-[hydroxy-[7-[[(1S)-2-methoxy-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-7-oxo-heptanoyl]amino]propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0068

3-[hydroxy-[8-[[(1R)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0136

3-[hydroxy-[8-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0371

3-[hydroxy-[8-[[(1S)-2-methoxy-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0466

5-tetrazolyl acetohydrazide

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0085

8-(hydroxyamino)-N-[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]-8-oxo-octanamide

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0258

methyl (2S)-2-[[4-[3-(hydroxyamino)-3-oxo-propyl]benzoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0706

methyl (2S)-2-[[7-(hydroxyamino)-7-oxo-heptanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.056

methyl (2S)-2-[[7-[hydroxy-(3-methoxy-3-oxo-propyl)amino]-7-oxo-heptanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0171

methyl (2S)-2-[[8-[hydroxy-(3-methoxy-3-oxo-propyl)amino]-8-oxo-octanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0563

methyl (S)-3-(2'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0476

methyl (S)-3-(3'-cyano-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.029

methyl (S)-3-(3'-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0483

methyl (S)-3-(4'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0548

methyl (S)-3-(4'-cyano-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0522

methyl (S)-3-(4'-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0939

methyl (S)-3-(6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0254

methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0276

methyl 3-(3'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0068

methyl 3-[hydroxy-[8-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.2

N-[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]heptanamide

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0145

N1-((3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)-N8-hydroxyoctanediamide

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0188

N1-(2-(3'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)ethyl)-N8-hydroxyoctanediamide

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0166

N1-(2-(3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)ethyl)-N8-hydroxyoctanediamide

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0254

SW55

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.0143

tert-butyl (2S)-2-[[8-(hydroxyamino)-8-oxo-octanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

0.201

tert-butyl (2S)-2-[[8-(hydroxyamino)-8-oxo-octanoyl]amino]-3-phenyl-propanoate

Homo sapiens

pH 7.5, 37°C, recombinant enzyme

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Release 2023.1 (January 2023)