1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase
This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.
Word Map on EC 1.14.11.69
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1.14.11.69
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demethylation
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demethylases
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chromatin
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jumonji
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trimethylation
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fbxl10
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polycomb
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heterochromatic
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hp1a
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analysis
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medicine
- 1.14.11.69
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demethylation
- demethylases
- chromatin
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jumonji
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trimethylation
- fbxl10
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polycomb
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heterochromatic
- hp1a
- analysis
- medicine
Reaction
Synonyms
AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM
ECTree
1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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dimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2
methyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2
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enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36
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histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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histone H3 N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
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histone H3 N6-methyl-L-lysine36 + 2-oxoglutarate + O2
histone H3 L-lysine36 + succinate + formaldehyde + CO2
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histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
trimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2
dimethyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2
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enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 26 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 26 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
[histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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?
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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KDM4A demethylates H3K36me3, a modification enriched in the 3' end of active genes
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histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
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histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
Aspergillus nidulans CBS 112.46
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[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
Aspergillus nidulans M139
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[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
Aspergillus nidulans NRRL 194
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[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
histone H3K36 methylation is enriched in coding regions of actively transcribed genes. dKDM4A is a JmjC domain-containing protein specifically demethylates H3K36me2 and H3K36me3 both in vitro and in vivo. H3K36 methylation is also subject to dynamic regulation. HP1a regulates histone H3K36 methylation in Drosophila larvae
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[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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JmjC domain-containing protein dKDM4A is a histone H3K36 demethylase. Histone H3 methylation is one of the consistent marks distinguishing alternative chromatin packaging states
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[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
[histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
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[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
[histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
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additional information
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HP1a and dKDM4A interact with each other and loss of HP1a leads to an increased level of histone H3K36me3
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additional information
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HP1a and dKDM4A interact with each other and loss of HP1a leads to an increased level of histone H3K36me3
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additional information
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JmjD2A is specific for H3K9me3 and H3K36me3 substrates. JmjD2A directly binds to regulatory regions of neural crest specifier genes in vivo
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additional information
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JMJD2A demethylates trimethylated histone K9/K36 to di- but not mono- or unmethylated products, i.e. JMJD2A also catalyzes the reactions of EC 1.14.11.66, H3K9 trimethyl demethylase
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additional information
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general function of histone demethylase for histone 3 L-lysine 36 is to promote transcription elongation by antagonizing repressive L-lysine 36 methylation by Set2 methyltransferase
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additional information
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Rph1 is a histone demethylase that can specifically demethylate tri- and dimethylated Lys36 of histone H3. 2-Oxoglutarate forms hydrogen-bonding interactions with the side chains of conserved residues. The substrate-binding cleft of Rph1 is formed with several structural elements of the JmjC domain, the long beta-hairpin and the mixed structural motif, and the methylated Lys36 of H3 is recognized by several conserved residues of the JmjC domain. Molecular basis for the substrate specificity of Rph1, overview
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additional information
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Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
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additional information
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Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
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