1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.

Reaction

Synonyms

AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase

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Results	in table
7	Activating Compound
16	AA Sequence
7	Application
26	Cloned(Commentary)
1	Cofactor
7	Crystallization (Commentary)
15	Disease/ Diagnostics
12	Expression
101	General Information
1	General Stability
31	IC50 Value
42	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
30	Localization
15	Metals/Ions
70	Natural Substrates/ Products (Substrates)
86	Organism
2	PDB ID
6	pH Optimum
5	Posttranslational Modification
43	Protein Variants
5	Purification (Commentary)
3	Reaction
51	Reference
46	Source Tissue
114	Substrates and Products (Substrate)
2	Subunits
142	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Turnover Number [1/s]

Disease

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Disease on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.

21937684

Neoplasm Metastasis

Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.

21937684

Neoplasm Metastasis

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.

23321669

Starvation

CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation.

24553073

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