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1.13.11.34: arachidonate 5-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
=
leukotriene A4
 +
H2O

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.34 arachidonate 5-lipoxygenase

IC50 Value

IC50 Value on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00077
(1-difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)acetic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.00044
(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)acetic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.005
(10E,12E)-octadeca-10,12-dien-8-ynoic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.06
(11E)-octadec-11-en-9-ynoic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0241
(17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine
Solanum tuberosum
-
pH 6.3, 25°C
0.0005
(1E)-1-((1-[(1Z)-prop-1-en-1-yldisulfanyl]propyl)sulfinyl)prop-1-ene
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00051
(1E)-1-(2,5-dihydroxyphenyl)-5-phenylpent-1-en-3-one
Homo sapiens
inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication
-
0.00052
(1E)-1-(3,4-dihydroxyphenyl)-6-phenylhex-1-en-3-one
Homo sapiens
inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication
-
0.00041
(1E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-5-phenylpent-1-en-3-one
Homo sapiens
inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication
-
0.0141
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0103
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.03
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0159 - 0.0358
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
0.013
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-[3-methoxy-4-(3-phenoxypropoxy)phenyl]prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0061
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-[4-(morpholin-4-ylcarbonyl)phenyl]prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0068
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-[4-(piperidin-1-ylcarbonyl)phenyl]prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0105
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-[4-(pyrrolidin-1-ylcarbonyl)phenyl]prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0079
(2E)-1-(2-hydroxy-4-methoxyphenyl)-3-[4-[(4-methylpiperazin-1-yl)carbonyl]phenyl]prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.00004
(2E)-3-(3,4-dihydroxyphenyl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.003
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.016
(2E)-3-[3-(2-ethoxyethoxy)phenyl]-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0097
(2E)-3-[4-(2-ethoxyethoxy)phenyl]-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0124
(2E)-3-[4-(3-ethoxypropoxy)-3-methoxyphenyl]-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.011
(2E)-3-[4-(benzyloxy)-3-bromo-5-methoxyphenyl]-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0102
(2E)-3-[4-(benzyloxy)phenyl]-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.00066 - 0.00246
(2E,2'E)-(1,1'-(2,2-bis((4-(((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)propane-1,3-diyl)bis(1H-1,2,3-triazole-4,1-diyl))bis(methylene) bis(3-(3,4-dihydroxyphenyl)acrylate)
0.00079 - 0.00237
(2E,2'E)-(1,1'-(2-((4-(((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(hydroxymethyl)propane-1,3-diyl)bis(1H-1,2,3-triazole-4,1-diyl))bis(methylene) bis(3-(3,4-dihydroxyphenyl)acrylate)
0.03
(2E,5E)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-3-phenyl-2-(phenylimino)-1,3-thiazolidin-4-one
0.000572
(2E,6E,10E)-13-((R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)-N-(4-methoxybenzyl)-2,6,10-trimethyltrideca-2,6,10-trienamide
Homo sapiens
pH 7.4, 37°C
-
0.000094
(2E,6E,10E)-13-((R)-6-hydroxy-2,8-dimethylchroman-2-yl)-N-(4-methoxybenzyl)-2,6,10-trimethyltrideca-2,6,10-trienamide
Homo sapiens
pH 7.4, 37°C
-
0.000077
(2E,6E,10E)-13-(6-hydroxy-2,8-dimethylchroman-2-yl)-2,6,10-trimethyl-N-(pyridin-3-ylmethyl)trideca-2,6,10-trienamide
Homo sapiens
pH 7.4, 37°C
-
0.000595
(2E,6E,10E)-N-benzyl-13-((R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2,6,10-trimethyltrideca-2,6,10-trienamide
Homo sapiens
pH 7.4, 37°C
-
0.00005
(2E,6E,10E)-N-benzyl-13-((R)-6-hydroxy-2,8-dimethylchroman-2-yl)-2,6,10-trimethyltrideca-2,6,10-trienamide
Homo sapiens
pH 7.4, 37°C
-
0.00011
(2Z)-2-[4-(acetylamino)phenyl]-3-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00013 - 0.00038
(5E)-2-(3-acetylphenyl)-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one
0.00012 - 0.00024
(5E)-2-(3-fluorophenyl)-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one
0.00011 - 0.00055
(5E)-2-(4-acetylphenyl)-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one
0.00063 - 0.00193
(5E)-2-(4-aminophenyl)-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one
0.00011 - 0.0004
(5E)-2-(4-chlorophenyl)-5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one
0.00009 - 0.00028
(5E)-2-(4-chlorophenyl)-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one
0.00065 - 0.00169
(5E)-2-(4-hydroxyphenyl)-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one
0.0004 - 0.00245
(5E)-2-(4-methylphenyl)-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazol-4(5H)-one
0.00098 - 0.00202
(5E)-5-(2,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.0008 - 0.0013
(5E)-5-(2-hydroxy-3-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.00048 - 0.00054
(5E)-5-(2-hydroxy-3-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.00013 - 0.00035
(5E)-5-(3,5-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.0027 - 0.01
(5E)-5-(3-chloro-4-hydroxy-5-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.003 - 0.0095
(5E)-5-(3-chloro-4-hydroxy-5-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.00125 - 0.0029
(5E)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.0003 - 0.00058
(5E)-5-(3-chlorobenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.003 - 0.0044
(5E)-5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.00032 - 0.004
(5E)-5-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-1,3-thiazol-4(5H)-one
0.0003 - 0.00066
(5E)-5-(4-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.00015 - 0.002
(5E)-5-(4-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.0003 - 0.00091
(5E)-5-(4-tert-butylbenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.00019 - 0.00211
(5E)-5-(4-[(methylperoxy)acetyl]benzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.0003 - 0.00065
(5E)-5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.0003 - 0.004
(5E)-5-(anthracen-9-ylmethylidene)-2-phenyl-1,3-thiazol-4(5H)-one
0.00035 - 0.00073
(5E)-5-benzylidene-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
0.02 - 0.03
(5E)-5-[4-(dimethylamino)benzylidene]-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one
0.012 - 0.014
(5Z)-2-(cyclohexylamino)-5-(4-propoxybenzylidene)-1,3-thiazol-4(5H)-one
0.03
(5Z)-5-(4-methoxybenzylidene)-2-(pyrrolidin-1-yl)-1,3-thiazol-4(5H)-one
0.03
(5Z)-5-(4-methylbenzylidene)-2-(naphthalen-2-ylamino)-1,3-thiazol-4(5H)-one
0.03
(5Z)-5-benzylidene-2-(phenylamino)-1,3-thiazol-4(5H)-one
0.0019
(R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl) methyl)-N-hydroxyheptanamide
Homo sapiens
pH 7.5, 25°C
-
0.0016
(R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl) methyl)-N-hydroxyoctanamide
Homo sapiens
pH 7.5, 25°C
-
0.0033
(R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-N-hydroxypentanamide
Homo sapiens
pH 7.5, 25°C
-
0.00011
(R)-N-(2-(diphenylamino)ethyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide, (R)-N-(3,3-bis(4-fluorophenyl)propyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide
Homo sapiens
pH 7.4, 37°C
-
0.00011
(R)-N-(3,3-bis(4-fluorophenyl)propyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide
Homo sapiens
-
pH 7.4, 37°C
-
0.0039
([3-chloro-5-(2,3-dihydro-1H-inden-4-ylamino)phenyl]sulfanyl)acetic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.005
([4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]sulfanyl)(naphthalen-1-yl)acetic acid
Homo sapiens
-
in intact polymorphonuclear leukocytes
0.029
1,4a-dimethyl-7-(propan-2-yl)-1-(prop-1-en-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene (non-preferred name)
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0006 - 0.007
1-(2,4-difluorophenyl)-3-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)urea
0.0068 - 0.01
1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
0.00087
1-(3,4-dichlorobenzyl)-3-(2-morpholin-4-yl-2-oxoethyl)-1H-indole
Rattus norvegicus
-
0.0028
1-(3,4-difluorophenyl)-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0021
1-(3-bromophenyl)-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0035
1-(3-chlorophenyl)-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0066
1-(3-ethylphenyl)-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0003 - 0.3
1-(3-hydroxyphenyl)-3-[4-(methylsulfonyl)phenyl]prop-2-yn-1-one
0.0013
1-(3-[5-(hydroxyureido)methyl-2-methoxyphenoxy]propyl)-3-[4-(trifluoromethoxy)phenyl]urea
Homo sapiens
pH 7.4, 37°C
0.00039
1-(4-aminosulfonylphenyl)-5-(2-chloropyridin-4-yl)-3-trifluoromethyl-1H-pyrazole
Solanum tuberosum
-
-
0.005
1-(4-aminosulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole
Solanum tuberosum
-
-
0.000016
1-(4-chlorobenzyl)-2-[2,2-dimethyl-3-(1H-tetrazol-5-yl)propyl]-4-methyl-6-[2-(5-phenylpyridin-2-yl)ethyl]-2,2a,4,5-tetrahydro-1H-thiopyrano[2,3,4-cd]indole
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00225
1-(4-chlorophenoxy)-5-methoxy-2-methyl-3-(4-morpholin-4-yl-4-oxobutyl)-1H-indole
Rattus norvegicus
-
0.00047
1-(4-methanesulfonylphenyl)-5-(2-chloropyridin-4-yl)-3-trifluoromethyl-1H-pyrazole
Solanum tuberosum
-
-
0.0044
1-(4-methanesulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole
Solanum tuberosum
-
-
0.0039
1-(6-methylpyridin-2-yl)-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0085
1-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)butan-1-one
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.008
1-(8-tert-butyl-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)-4-cyclopropylbutan-1-one
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.76
1-(benzyloxy)hept-2-yn-4-ol
Solanum tuberosum
-
-
0.0034
1-(difluoromethyl)-5-[[2-(methylsulfonyl)phenyl]ethynyl]pyridin-2(1H)-one
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.003 - 0.01
1-benzyl-3-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)urea
0.00317
1-benzyl-3-(3-morpholin-4-yl-3-oxopropyl)-1H-indole
Rattus norvegicus
-
0.00085
1-benzyl-3-(4-oxo-4-piperazin-1-ylbutyl)-1H-indole
Rattus norvegicus
-
0.00095
1-benzyl-5-chloro-2-methyl-3-(4-morpholin-4-yl-4-oxobutyl)-1H-indole
Rattus norvegicus
-
0.0038
1-hydroxy-1-[1-(5-methoxy-1-methyl-1H-indol-2-yl)ethyl]urea
Rattus norvegicus
-
pH and temperature not specified in the publication
0.005
1-O-dodecyl 2,3-O-isopropylidene-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethyl) phenylaminocarbonyl] amino-beta-L-gulofuranoside sodium salt
Homo sapiens
-
competitive inhibitor, IC50: 0.0035 mM with recombinant enzyme, IC50: 0.005 mM with native enzyme
0.0039
1-phenyl-5-(propan-2-yl)-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.045
1-[(4methylbenzyl)oxy]hept-2-yn-4-ol
Solanum tuberosum
-
-
0.0056
1-[1-(6-tert-butyl-1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0049
1-[3-(benzyloxy)phenyl]-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.001 - 0.004
1-[3-(methylsulfanyl)phenyl]-3-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)urea
0.00034
1-[4-([3-fluoro-5-[4-(methylsulfinyl)tetrahydro-2H-pyran-4-yl]phenoxy]methyl)phenyl]-2-methyl-1H-imidazole
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000195
1-[4-([3-fluoro-5-[4-(methylsulfonyl)tetrahydro-2H-pyran-4-yl]phenoxy]methyl)phenyl]-2-methyl-1H-imidazole
Rattus norvegicus
-
pH and temperature not specified in the publication
0.017
10,17(S)-dihydroxydocosahexaenoic acid
Homo sapiens
-
IC50: 0.017 mM
0.0006
10-nitro-oleic acid
Homo sapiens
pH 7.4, 37°C
-
0.015
11,14,17-Eicosatrienoic acid
Rattus norvegicus
-
IC50: 0.015 mM
0.0048
15-hydroperoxy-6,8,11,13-eicosatetraenoic acid
Homo sapiens
-
IC50: 0.0048 mM
0.05
2,3-dichlorophenyl 3,5-dinitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.00026
2,5-dimethoxy-3-tridecylbenzene-1,4-diol
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0037
2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)propanoic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.0002
2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.00025
2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)propanoic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.00046
2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)acetic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.003
2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)propanoic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.0015
2-(2,2-dimethyl-6-(4-nitrophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid
Homo sapiens
-
-
0.00031
2-(2,2-dimethyl-7-phenyl-6-(4-(trifluoromethyl)phenyl)-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid
Homo sapiens
-
-
0.1
2-(2,4-dihydroxyphenyl)-8,8-dimethyl-3-(3-methylbut-2-en-1-yl)-4H,8H-pyrano[2,3-f]chromen-4-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.004 - 0.01
2-(2-methoxyphenyl)-N-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)acetamide
0.0055
2-(2-[ethyl(hydroxy)amino]ethyl)dibenzo[b,e]oxepin-11(6H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.03
2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.02 - 2
2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0032
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0036
2-(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c]chromene-3,6,9-triol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0049
2-(3-[hydroxy(methyl)amino]propyl)dibenzo[b,e]oxepin-11(6H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0007 - 0.0015
2-(4-(biphenyl-4-ylamino)-6-chloropyrimidine-2-ylthio)octanoic acid
0.001 - 0.002
2-(4-(biphenyl-4-ylmethylamino)-6-chloropyrimidin-2-ylthio)octanoic acid
0.0004 - 0.0015
2-(4-chloro-6-(4'-cyanobiphenyl-4-ylamino)pyrimidin-2-ylthio)octanoic acid
0.0005 - 0.002
2-(4-chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamino)pyrimidin-2-ylthio)octanoic acid
0.00023 - 0.0004
2-(4-methylphenyl)-5-(2-phenylethenylidene)-1,3-thiazol-4(5H)-one
0.0008 - 0.001
2-(5,8-dimethyl-7-propoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N-(5-methyl-1,3-thiazol-2-yl)propanamide
0.0008 - 0.001
2-(5,8-dimethyl-7-propoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N-1,3-thiazol-2-ylpropanamide
0.0009 - 0.006
2-(5,8-dimethyl-7-propoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N-pyridin-2-ylpropanamide
0.003 - 0.008
2-(5,8-dimethyl-7-propoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N-thiophen-3-ylpropanamide
0.00023
2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-N-(methylsulfonyl)acetamide
Homo sapiens
-
-
0.00025
2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-N-(phenylsulfonyl)acetamide
Homo sapiens
-
-
0.00026
2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-N-tosylacetamide
Homo sapiens
-
-
0.0016
2-(6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid
Homo sapiens
-
-
0.00018
2-(6-(4-tert-butylphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid
Homo sapiens
-
-
0.008 - 0.01
2-(7-methoxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-(thiophen-2-ylmethyl)propanamide
0.0008 - 0.005
2-(7-methoxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-pyridin-2-ylpropanamide
0.0008 - 0.01
2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.0041 - 0.0065
2-([4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]sulfanyl)octanoic acid
0.01
2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.0014 - 0.003
2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.0046 - 0.01
2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
0.00078 - 0.0023
2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
0.01
2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
0.00028 - 0.0067
2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
0.00032 - 0.00033
2-phenylethyl (2E)-3-(2,5-dihydroxyphenyl)prop-2-enoate
-
0.00029
2-phenylethyl (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate
Homo sapiens
inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication
-
0.01
2-[(1-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)ethynyl]benzenesulfonamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.0015 - 0.003
2-[(4-[[3,5-bis(2,2,2-trifluoroethoxy)phenyl]amino]-6-chloropyrimidin-2-yl)sulfanyl]octanoic acid
0.002
2-[2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.00037
2-[3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.006
2-[4'-(iso-propylphenyl)-amino]-5,6-dimethyl-1,4-benzoquinone
Homo sapiens
-
potent inhibitor, IC50: 0.006 mM
0.003
2-[4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.00068
2-[4-([[(2E)-3-phenylprop-2-enoyl]oxy]methyl)-1H-1,2,3-triazol-1-yl]ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
0.00018
2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
Homo sapiens
-
-
0.001 - 0.01
2-[7-[2-(dimethylamino)ethoxy]-5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl]-N-1,3-thiazol-2-ylpropanamide
0.005
2-[[5-fluoro-6-(4-fluorophenoxy)-1H-benzimidazol-2-yl]sulfanyl]-2-methylpropanoic acid
Glycine max
-
pH 7.0, 25°C
-
0.01
3'-nitrobiphenyl-2,4-diol
0.0009 - 0.01
3,4,5-trimethoxy-N-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)benzamide
0.00031
3,4,6-trimethoxy-5-undecylcyclohexa-2,4-dien-1-one
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.05
3-((naphthalene-1-yloxy)carbonyl)benzoic acid
Homo sapiens
pH 7.4, 37°C
0.00146
3-(1,10-dihydroxydecyl)-2,5-dimethoxycyclohexa-2,5-diene-1,4-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00049
3-(1-acetoxy-10-hydroxydecyl)-2,5-dimethoxycyclohexa-2,5-diene-1,4-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00037
3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.00175
3-(10-hydroxydecyl)-2,5-dimethoxycyclohexa-2,5-diene-1,4-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00108
3-(10-hydroxydecyl)-4,5-dimethoxycyclohexa-3,5-diene-1,2-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00151
3-(11-hydroxyundecyl)-2,5-dimethoxycyclohexa-2,5-diene-1,4-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00196
3-(11-hydroxyundecyl)-4,5-dimethoxycyclohexa-3,5-diene-1,2-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.01
3-(2-(2-[(4-chlorophenyl)sulfanyl]ethoxy)-3-methoxy-5-[5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]benzyl)-1-hydroxy-1-methylurea
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0007
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
Homo sapiens
pH 7.4, 37°C
-
0.00011
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(3-phenyl-3-(4-(trifluoromethoxy)phenyl)propyl)benzamide
Homo sapiens
pH 7.4, 37°C
-
0.0017
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-benzamide
Homo sapiens
pH 7.4, 37°C
-
0.0003
3-(3-(1-hydroxyureido)hex-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
Homo sapiens
pH 7.4, 37°C
-
0.0042
3-(4,5-dihydroxy-2-methyl-9,10-dioxo-4a,9,9a,10-tetrahydroanthracen-1-yl)-2-hydroxy-4,6-dimethoxybenzoic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00206
3-(4-morpholin-4-yl-4-oxobutyl)-1H-indole
Rattus norvegicus
-
0.00184
3-(8-hydroxyoctyl)-2,5-dimethoxycyclohexa-2,5-diene-1,4-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00022
3-(8-hydroxyoctyl)-4,5-dimethoxycyclohexa-3,5-diene-1,2-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.05
3-(benzyloxycarbonyl)benzoic acid
Homo sapiens
pH 7.4, 37°C
0.01
3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
0.00058 - 0.011
3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
0.05
3-(naphhthalen-1-ylcarbmoyl)benzoic acid
Homo sapiens
pH 7.4, 37°C
0.05
3-(phenylcarbamoyl)benzoic acid
Homo sapiens
pH 7.4, 37°C
0.01
3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
0.00024
3-dodecyl-4,5-dimethoxybenzene-1,2-diol
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00013
3-dodecyl-4,5-dimethoxycyclohexa-3,5-diene-1,2-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0015
3-ethoxy-11-oxours-12-en-23-oic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00274
3-n-pentadecylcatechol
Homo sapiens
pH 7.5, temperature not specified in the publication
-
0.0065
3-propylphenyl 3,5-dinitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.0005
3-tolyl 3,5-dinitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.00006
3-tridecyl-4,5-dimethoxybenzene-1,2-diol
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0001
3-undecyl-4,5-dimethoxybenzene-1,2-diol
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00116
3-[(10E)-pentadec-10'-en-1-yl]-catechol
Homo sapiens
i.e. a catechol mixture from Lithrea caustica containing 65% of the compound, pH 7.5, temperature not specified in the publication
-
0.00209
3-[(10Z)-pentadec-10'-en-1-yl]-catechol
Homo sapiens
pH 7.5, temperature not specified in the publication
-
0.00238
3-[2-[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]ethyl]-1H-indole
Rattus norvegicus
-
0.32
3-[4-(methylsulfonyl)phenyl]-1-[4-(propan-2-yl)phenyl]prop-2-yn-1-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0005
3-[5-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4-dihydroxyphenyl]-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000003
3-[[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00008
4,5-dimethoxy-3-tridecylcyclohexa-3,5-diene-1,2-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00009
4,5-dimethoxy-3-undecylcyclohexa-3,5-diene-1,2-dione
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0013
4,7,10,13,16,19-docosahexaenoic acid
Rattus norvegicus
-
IC50: 0.0013 mM
0.0085
4,9-dimethoxy-3-methyl-9,10-dihydrophenanthrene-2,7-diol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.01
4-(1-benzothiophen-3-yl)benzene-1,3-diol
0.074
4-(1-benzyl-1H-indol-3-yl)-1-morpholinobutan-1-one
Rattus norvegicus
-
0.00347
4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
Solanum tuberosum
-
pH and temperature not specified in the publication
0.001
4-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
Homo sapiens
pH 7.4, 37°C
-
0.0068
4-(3-fluoro-5-[[4-(2-methyl-1H-imidazol-1-yl)benzyl]oxy]phenyl)-N-methyltetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0006
4-(3-fluoro-5-[[4-(2-methyl-1H-imidazol-1-yl)benzyl]oxy]phenyl)tetrahydro-2H-pyran-4-ol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00054
4-(3-fluoro-5[[4-(2-methyl-1H-imidazol-1-yl)benzyl]oxy]phenyl)tetrahydro-2H-pyran-4-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00004
4-(4-(4-chlorophenyl)thiazol-2-ylimino)cyclohexa-2,5-dienone
Homo sapiens
pH 7.4, 37°C, recombinant enzyme
0.00018
4-(4-chlorophenyl)-7-([3-fluoro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]sulfanyl)-2H-chromen-2-one
Homo sapiens
-
IC50: 180 nM
0.008
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-1,2-selenazole
Bos taurus
-
-
0.000055
4-(4-fluorophenyl)-7-([3-fluoro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenoxy]methyl)-2H-chromen-2-one
Homo sapiens
-
IC50: 55 nM
0.000027
4-(4-fluorophenyl)-7-([3-fluoro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]sulfanyl)-2H-chromen-2-one
Homo sapiens
-
IC50: 27 nM
0.003
4-(6-methoxynaphthalen-2-yl)butan-2-one
Rattus norvegicus
-
value above, pH and temperature not specified in the publication
0.0077
4-(acetyloxy)-2-[4-(acetyloxy)-6-methylhept-5-en-2-yl]cyclohexyl (2Z)-2-methylbut-2-enoate
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0063 - 0.01
4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
0.0055
4-(furan-3-yl)-7-[[2-(tetrahydro-2H-pyran-4-yl)pyridin-4-yl]methoxy]naphthalene-2-carbonitrile
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000015
4-(furan-3-yl)-7-[[6-(4-hydroxytetrahydro-2H-pyran-4-yl)pyridin-2-yl]methoxy]naphthalene-2-carbonitrile
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.0038
4-(furan-3-yl)-7-[[7-(tetrahydro-2H-pyran-4-yl)-1,2,3,4-tetrahydroquinolin-2-yl]oxy]naphthalene-2-carbonitrile
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0023 - 0.0074
4-(naphthalen-2-ylmethyl)benzene-1,3-diol
0.0021 - 0.0032
4-(thianthren-2-yl)benzene-1,3-diol
0.035
4-([[5-fluoro-6-(1H-1,2,4-triazol-1-yl)-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid
Glycine max
-
pH 7.0, 25°C
-
0.0009
4-([[5-fluoro-6-(4-fluorophenoxy)-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid
Glycine max
-
pH 7.0, 25°C
-
0.003
4-([[6-(4-chlorophenoxy)-5-fluoro-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid
Glycine max
-
pH 7.0, 25°C
-
0.009 - 0.01
4-benzylbenzene-1,3-diol
0.00042
4-chloro-N-([4-[(2E)-3-(2,4-dichlorophenyl)prop-2-enoyl]phenyl]carbamoyl)benzenesulfonamide
Homo sapiens
-
IC50: 0.00042 mM
0.00083
4-chloro-N-([4-[(2E)-3-phenylprop-2-enoyl]phenyl]carbamoyl)benzenesulfonamide
Homo sapiens
-
IC50: 0.00083 mM
0.0028 - 0.0046
4-hexylbenzene-1,3-diol
0.00001
4-methoxy-4-[3-(naphthalen-2-ylmethoxy)phenyl]tetrahydro-2H-pyran
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.006 - 0.01
4-methoxy-N-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)benzamide
0.01
4-methyl-N-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)-1,2,3-thiadiazole-5-carboxamide
0.00045
4-methyl-N-([4-[(2E)-3-(2,3,4-trimethylphenyl)prop-2 enoyl]phenyl]carbamoyl)benzenesulfonamide
Homo sapiens
-
IC50: 0.00045 mM
0.00089
4-methyl-N-([4-[(2E)-3-phenylprop-2-enoyl]phenyl]carbamoyl)benzenesulfonamide
Homo sapiens
-
IC50: 0.00089 mM
0.0114
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-(2-hydroxy-5-nitrophenyl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0165
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-(2-hydroxyphenyl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0249
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-(2-methoxyphenyl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0142
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-(2-phenylethyl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0221
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-(propan-2-yl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0204
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-methyl-N-phenylbenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0129
4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-N-propylbenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.03
4-[([5-fluoro-6-[4-(1H-imidazol-1-yl)phenoxy]-1H-benzimidazol-2-yl]sulfanyl)methyl]benzoic acid
Glycine max
-
pH 7.0, 25°C
-
0.000036
4-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-2,2a,4,5-tetrahydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-N-(methylsulfonyl)butanamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00007
4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethylphenol
Rattus norvegicus
-
in 50 mM Tris-HCl buffer (pH 7.4) containing 0.4 mM CaCl2+ , 0.024 mg/ml alpha-phosphatidylcholine and 0.02 mM ATP, at 22°C
0.041
4-[5-(1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.01
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00003
4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
Homo sapiens
pH 7.4, 37°C, recombinant enzyme
0.002
5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0048
5,5-dimethyl-1-phenyl-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.028
5,8,11,13-eicosatetraynoic acid
Rattus norvegicus
-
IC50: 0.028 mM
0.00077
5-(2-[[3-(trifluoromethyl)phenyl]amino]phenyl)-1,3,4-oxadiazole-2(3H)-thione
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.003
5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
Rattus norvegicus
-
value above, pH and temperature not specified in the publication
0.006
5-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-5-oxopentanenitrile
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00341
5-amino-2-hydroxy-N-(propan-2-yl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.00765
5-amino-N-cyclohexyl-2-hydroxybenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.00841
5-amino-N-hexyl-2-hydroxybenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.0084
5-butyl-1-phenyl-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00133
5-chloro-2-methyl-3-(4-morpholin-4-yl-4-oxobutyl)-1H-indole
Rattus norvegicus
-
0.006
5-ethyl-1-phenyl-1,2,4-triazinan-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00316
5-methoxy-2-methyl-3-(4-morpholin-4-yl-4-oxobutyl)-1H-indole
Rattus norvegicus
-
0.00029
5-methoxy-3-tridecylbenzene-1,2,4-triol
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.00137
5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00796
5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.00092
6-hydroxy-3,4-dimethoxy-5-undecylcyclohexa-2,4-dien-1-one
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.009 - 0.01
6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
0.00033
6-[[3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy]methyl]-1-methylquinolin-2(1H)-one
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.007
7,17(S)-dihydroxydocosahexaenoic acid
Homo sapiens
-
IC50: 0.007 mM
0.0069
7,8-dihydroxy-2H-chromen-2-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.01
7-(4-methylphenyl)-6-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-pyrrolizine
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.000175
7-([3-fluoro-5-[(1R)-1-hydroxy-1-pyridin-2-ylpropyl]phenoxy]methyl)-4-furan-3-yl-2H-chromen-2-one
Homo sapiens
-
IC50: 175 nM
0.0002
7-([3-fluoro-5-[(1R,3R,5S)-3-hydroxy-6,8-dioxabicyclo[3.2.1]oct-3-yl]phenoxy]methyl)-4-furan-3-yl-2H-chromen-2-one
Homo sapiens
-
IC50: 200 nM
0.0003
7-([3-fluoro-5-[(1R,3R,5S)-3-hydroxy-6,8-dioxabicyclo[3.2.1]oct-3-yl]phenoxy]methyl)-4-phenyl-2H-chromen-2-one
Homo sapiens
-
IC50: 300 nM
0.000175
7-([3-fluoro-5-[(1S)-1-hydroxy-1-(1,3-thiazol-2-yl)propyl]phenoxy]methyl)-4-(4-fluorophenyl)-2H-chromen-2-one
Homo sapiens
-
IC50: 175 nM
0.000009
7-([3-fluoro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]sulfanyl)-4-furan-3-yl-2H-chromen-2-one
Homo sapiens
-
IC50: 9 nM
0.000026
7-([3-fluoro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]sulfanyl)-4-phenyl-2H-chromen-2-one
Homo sapiens
-
IC50: 26 nM
0.022
7-tert-butyl-N-ethyl-N,3,3-trimethyl-2,3-dihydro-1-benzofuran-5-carboxamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.000015
7-[[3-(1-ethyl-1-hydroxypropyl)-5-fluorophenoxy]methyl]-4-furan-3-yl-2H-chromen-2-one
Homo sapiens
-
IC50: 15 nM
0.000014
7-[[3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl]oxy]-4-phenylnaphtho[2,3-c]furan-1(3H)-one
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.000027
7-[[3-fluoro-5-(3-hydroxy-6,8-dioxabicyclo[3.2.1]oct-3-yl)phenoxy]methyl]-4-(furan-3-yl)quinoline-2-carbonitrile
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00219
8,11,14-eicosatrienoic acid
Rattus norvegicus
-
IC50: 0.00219 mM
0.0038
AA-861
Homo sapiens
pH 7.4, 37°C
0.0026 - 0.01
AA861
0.0039
acetonylacetone bisphenylhydrazone
Solanum tuberosum
-
IC50 for reaction with linoleic acid: 0.015 mM, IC50 for reaction with arachidonic acid: 0.0039 mM
0.00023
arachidonic acid
Rattus norvegicus
-
induces time-dependent enzyme inactivation at concentrations 100fold lower than the Km-value, IC50: 0.00023 mM
0.0166
arachidonoyl lysophosphatidylcholine
Solanum tuberosum
-
pH 6.3, 25°C
0.00029 - 0.0012
baicalein
0.0014
benzaldehyde phenylhydrazone
Solanum tuberosum
-
IC50 for reaction with linoleic acid: 0.0345 mM, IC50 for reaction with arachidonic acid: 0.0014 mM
0.00013 - 0.00035
benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00017 - 0.00048
benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0028 - 0.0042
biphenyl-2,4-diol
0.038
biphenyl-3-yl 3,5-dinitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.05
biphenyl-4-yl 3,5-dinitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.0048
BRP-7
Homo sapiens
pH 7.4, 37°C
0.004 - 0.53
BW755C
0.0002
BWA4C
Homo sapiens
pH 7.4, 37°C
0.004 - 0.046
caffeic acid
0.00097
caffeic acid phenethyl ester
Homo sapiens
inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication
0.062
catechol
Rattus norvegicus
-
IC50: 0.062 mM
0.0195
celecoxib
Homo sapiens
-
37°C, whole blood assay
0.0007
chalcone
Homo sapiens
pH 7.4, 37°C
0.098
Cirsiliol
Rattus norvegicus
-
IC50: 0.098 mM
0.00115 - 0.00155
CJ-13610
Homo sapiens
-
pH 7.5, 37°C, dependent on assay method via fluorescence or UV measurement, kinetics, overview
0.0014
curcumin
Homo sapiens
pH 7.4, 37°C
0.05
cyrhetrenyl carboxylic acid
Homo sapiens
above 0.050 mM, pH 7.5, 23°C
-
0.157
daidzein
Homo sapiens
-
pH 7.4, 27°C
0.0069
delphinidin 3-O-galactoside
Homo sapiens
-
-
0.00215
delphinidin 3-O-glucoside
Homo sapiens
-
-
0.000057
delta-garcinoic acid
Homo sapiens
pH 7.4, 37°C
-
0.002 - 0.005
diphenyldisulfide
Sus scrofa
-
IC50: 0.002-0.005 mM
0.00065
eicosapentaenoic acid
Rattus norvegicus
-
induces time-dependent enzyme inactivation at concentrations 100fold lower than the Km-value, IC50: 0.00065 mM
0.00023
embelin
Homo sapiens
pH 7.4, 37°C
0.98
epinephrine
Rattus norvegicus
-
IC50: 0.98 mM
0.0045
esculetin
Rattus norvegicus
-
IC50: 0.0045 mM
0.00065 - 0.0018
ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0032
ethyl 2-((2,4-difluorophenylthio)methyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0008
ethyl 2-((2,6-dichlorophenylthio)methyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0008
ethyl 2-((2,6-dimethylphenylthio)methyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0018
ethyl 2-((3,5-dimethylphenylthio)methyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0038
ethyl 2-((3-chlorophenylthio)methyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.005
ethyl 2-((4-fluorophenylthio)methyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.000097 - 0.0012
ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0016 - 0.0017
ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.00015 - 0.00045
ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000086 - 0.00023
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0017 - 0.002
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.00058 - 0.0043
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate
0.0012 - 0.0057
ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate
0.01 - 0.03
ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate
0.03
ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate
0.007 - 0.01
ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000045 - 0.00052
ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0033 - 0.0048
ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
0.00014 - 0.00034
ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00013 - 0.00052
ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000095 - 0.0006
ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000084 - 0.0012
ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0007 - 0.0012
ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.000067 - 0.00032
ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.002 - 0.0021
ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
0.000096 - 0.0005
ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00015 - 0.00065
ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00025 - 0.0017
ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0003 - 0.0024
ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate
0.000031 - 0.00049
ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0017 - 0.0028
ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
0.000049 - 0.0028
ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0007 - 0.0039
ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
0.0006 - 0.019
ethyl 2-[[4-chloro-6-(quinolin-6-ylamino)pyrimidin-2-yl]sulfanyl]octanoate
0.0034 - 0.01
ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate
0.0008
ethyl 5-hydroxy-1-methyl-2-((2-(trifluoromethyl)phenylthio)methyl)-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0009
ethyl 5-hydroxy-1-methyl-2-((4-(trifluoromethoxy)phenylthio)methyl)-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0042
ethyl 5-hydroxy-1-methyl-2-((4-(trifluoromethyl)phenylthio)methyl)-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0057
ethyl 5-hydroxy-1-methyl-2-(phenylthiomethyl)-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0029
ethyl 5-hydroxy-2-((2-methoxyphenylthio)methyl)-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0023
ethyl 5-hydroxy-2-((4-methoxyphenylthio)methyl)-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0007
ethyl 5-hydroxy-2-(mesitylthiomethyl)-1-methyl-1H-indole-3-carboxylate
Homo sapiens
pH 7.4, 37°C, cell-free enzyme extract
0.0055 - 0.0073
ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate
0.00013 - 0.00044
ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate
0.00033 - 0.0028
ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.026
eugenol
Homo sapiens
-
non-competitive, reversible inhibitor, IC50: 0.026 mM
0.098
eupatilin
Rattus norvegicus
-
IC50: 0.098 mM
0.0025
ferrocenyl carboxylic acid
Homo sapiens
pH 7.5, 23°C
-
0.125
genistein
Homo sapiens
-
pH 7.4, 27°C
0.36
indomethacin
Rattus norvegicus
-
IC50: 0.36 mM
0.0003 - 0.0004
L-651,896
Sus scrofa
-
i.e. 2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol, IC50: 0.0003-0.0004 mM
0.0003 - 0.0008
L-656,224
0.0004
L-670,630
Homo sapiens
-
IC50: 0.0004 mM
0.0003
L-689,065
Homo sapiens
-
IC50: 0.0003 mM
0.00002
L-697,198
Homo sapiens
-
IC50: 0.00002 mM
0.0015
L-702,701
Homo sapiens
-
IC50: 0.0015 mM
0.000027
L-746,530
Homo sapiens
-
IC50: 27 nM
0.00002
L705,302
Homo sapiens
-
IC50: 0.00002 mM
0.00006
luteolin
Homo sapiens
pH 7.4, 37°C
0.00058 - 0.00086
methyl (4-[(5E)-5-(4-methoxybenzylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]phenoxy)acetate
0.03
methyl 2-(allylamino)-1H-indole-3-carboxylate
0.0034 - 0.004
methyl 2-(benzylamino)-1H-indole-3-carboxylate
0.0069 - 0.0125
methyl 2-(diallylamino)-1H-indole-3-carboxylate
0.0098 - 0.0102
methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0035 - 0.0083
methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate
0.0065 - 0.0081
methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0035 - 0.0055
methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate
0.0079 - 0.0134
methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate
0.0072 - 0.0098
methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate
0.004
miogadial
Homo sapiens
-
potent inhibitor, IC50: 0.004 mM
0.0075
miogatrial
Homo sapiens
-
potent inhibitor, IC50: 0.0075 mM
0.0032
MK-886
Homo sapiens
-
37°C, whole blood assay
0.0011
MK886
Homo sapiens
pH 7.4, 37°C
0.1
ML-3000
Homo sapiens
-
above, 37°C, whole blood assay
0.0163
N-(2,4-dimethylphenyl)-4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.05
N-(3,4-dimethoxyphenyl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.002 - 0.01
N-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)-1,3-benzodioxole-5-carboxamide
0.008 - 0.01
N-(3,5a,10-trimethyl-2-oxo-2,3,3a,4,5,5a,6,10,10a,10b-decahydrofuro[3',2':7,8]naphtho[2,3-d][1,3]thiazol-8-yl)cyclopentanecarboxamide
0.00012
N-(3-(4-chlorophenyl)-3-phenylpropyl)-3-(3-(1-hydroxyureido)-but-1-yn-1-yl)benzamide
Homo sapiens
pH 7.4, 37°C
-
0.0144
N-(3-bromobenzyl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.05
N-(3-bromophenyl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.05
N-(3-chlorophenyl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.000038 - 0.00016
N-(3-phenoxycinnamyl)-acetohydroxamic acid
0.0001
N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea
Homo sapiens
-
IC50: 0.0001 mM
0.0027
N-(4-methoxyphenyl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.05
N-(biphenyl-3-yl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.0009 - 0.01
N-(furan-2-ylmethyl)-2-(7-methoxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide
0.05
N-(naphthalene-1-yl)-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.0039
N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)-N-hydroxy-2-methylpropanamide
Homo sapiens
pH 7.5, 25°C
-
0.0035
N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)-N-hydroxycyclopropanecarboxamide
Homo sapiens
pH 7.5, 25°C
-
0.00045
N-([4-[(2E)-3-(2,4-dichlorophenyl)prop-2-enoyl]phenyl]carbamoyl)-4-methylbenzenesulfonamide
Homo sapiens
-
IC50: 0.00045 mM
0.05
N-3-tolyl-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.018
N-benzyl-4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0105
N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.0113
N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.0123
N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.01
N-cyclopentyl-2-[7-(2-methoxyethoxy)-5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide
0.0157
N-dodecyl-4-[(1E)-3-(2-hydroxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
0.0119
N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide
Solanum tuberosum
-
pH 7.4, temperature not specified in the publication
-
0.00005 - 0.15
N-hydroxy-N-[(2E)-3-(3-phenoxyphenyl)prop-2-en-1-yl]acetamide
0.00119
N-hydroxy-N-[1-(1-methyl-1H-indol-2-yl)ethyl]acetamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0005
N-methyl-2[4-(2,4,6-trimethylphenyl)phenyl]-propenehydroxamic acid
Sus scrofa
-
IC50: 0.0005 mM
0.0152
N-phenyl-3,5-dinitrobenzamide
Homo sapiens
pH 7.4, 37°C
0.004 - 0.01
N-tert-butyl-2-(7-methoxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide
0.01
N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.00013
N-[5-(4-fluorophenoxy)thiophen-2-yl]methanesulfonamide
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
0.0246
naphthalene-1-yl 3-nitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.003
NAPQI
Homo sapiens
pH 7.4, 37°C
-
0.00009 - 0.0125
nordihydroguaiaretic acid
0.00021 - 0.0365
nordihydroguiaraetic acid
0.49
norepinephrine
Rattus norvegicus
-
IC50: 0.49 mM
0.0656
ochnaflavone
Mus musculus
-
IC50: 0.0656 mM
0.005 - 0.01
Phenidone
Sus scrofa
-
IC50: 0.005-0.01 mM
0.0158
phenyl 3,5-dinitrobenzoate
Homo sapiens
pH 7.4, 37°C
0.00143
Plumbagin
Homo sapiens
pH 7.4, 37°C
0.0086
polygodial
Homo sapiens
-
strong inhibitory activity, IC50: 0.0086 mM
0.0006
primin
Homo sapiens
pH 7.4, 37°C
-
0.0003 - 0.0021
quercetin
0.033
rutin
Rattus norvegicus
-
IC50: 0.033 mM
0.00013
SC-756
Homo sapiens
-
pH 7.5, 37°C, assay method via fluorescence measurement
0.0005
shikonin
Homo sapiens
pH 7.4, 37°C
0.0006
shogaol
Homo sapiens
pH 7.4, 37°C
0.02
sulindac sulfide
Homo sapiens
-
pH and temperature not specified in the publication
0.00074
tert-butyl 4-[4-(1H-indol-3-yl)butanoyl]piperazine-1-carboxylate
Rattus norvegicus
-
0.00017
U73122
Homo sapiens
pH 7.4, 37°C
0.0003
ZD 2138
Homo sapiens
-
i.e. CAS: 140841-32-3, IC50: 0.0003 mM
0.00011 - 0.00012
ZD-2138
Homo sapiens
-
pH 7.5, 37°C, dependent on assay method via fluorescence or UV measurement
0.00012 - 0.0156
zileuton
0.00009
ZM 230,486
Homo sapiens
-
IC50: 0.00009 mM
0.00074 - 0.00148
[1-(2-[[(2E)-3-phenylprop-2-enoyl]oxy]ethyl)-1H-1,2,3-triazol-4-yl]methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
0.0075
[2-[(1S,8aR)-2-formyl-5,5,8a-trimethyldecahydronaphthalen-1-yl]ethylidene]propanedial
Solanum tuberosum
-
in 100 mM phosphate buffer, pH 6.3, 25°C
additional information
additional information
-