1.13.11.34: arachidonate 5-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.34
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1.13.11.34
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cyclooxygenase
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prostaglandin
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leukocyte
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neutrophil
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eicosanoids
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cox-2
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asthma
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indomethacin
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ionophore
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phospholipase
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zileuton
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polymorphonuclear
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thromboxane
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flap
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airway
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peritoneal
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5-hete
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platelet
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eosinophil
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mast
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cysteinyl
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allergic
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edema
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12-lipoxygenase
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histamine
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lta4
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nordihydroguaiaretic
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lipoxygenases
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paf
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ndga
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bronchoconstriction
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5-hydroxyeicosatetraenoic
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asthmatic
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basophil
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platelet-activating
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anaphylaxis
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zymosan
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antigen-induced
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lipoxins
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montelukast
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hetes
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mpges-1
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carrageenan-induced
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a23187-stimulated
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paf-induced
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pro-resolving
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synthesis
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bronchospasm
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medicine
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drug development
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14carachidonic
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pharmacology
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bronchoconstrictors
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ulcerogenic
- 1.13.11.34
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cyclooxygenase
- prostaglandin
- leukocyte
- neutrophil
-
eicosanoids
- cox-2
- asthma
- indomethacin
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ionophore
- phospholipase
- zileuton
-
polymorphonuclear
-
thromboxane
- flap
- airway
- peritoneal
-
5-hete
- platelet
-
eosinophil
-
mast
-
cysteinyl
-
allergic
- edema
-
12-lipoxygenase
- histamine
- lta4
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nordihydroguaiaretic
- lipoxygenases
- paf
- ndga
-
bronchoconstriction
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5-hydroxyeicosatetraenoic
-
asthmatic
-
basophil
-
platelet-activating
- anaphylaxis
- zymosan
-
antigen-induced
-
lipoxins
- montelukast
-
hetes
- mpges-1
-
carrageenan-induced
-
a23187-stimulated
-
paf-induced
-
pro-resolving
- synthesis
- bronchospasm
- medicine
- drug development
-
14carachidonic
- pharmacology
-
bronchoconstrictors
-
ulcerogenic
Reaction
Synonyms
5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase
ECTree
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Localization
Localization on EC 1.13.11.34 - arachidonate 5-lipoxygenase
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when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane
iron removal is able to affect the membrane binding properties of the enzyme, molecular dynamics simulations, overview
additional information
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polymorphonuclear leukocytes: translocation of cytosolic enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein
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Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein, FLAP
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in resting cells, 5LO resides either in the cytosol (e.g. in neutrophils, eosinophils, peritoneal macrophages) or in a nuclear soluble compartment associated with chromatin (e.g. in alveolar macrophages, Langerhans cells, basophilic leukemia cells)
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when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane
being a mobile enzyme, 5-LO migrates from the cytosol to the nuclear envelope
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in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein
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the enzyme is activated by a Ca2+-mediated translocation to membranes. The enzyme binds to membranes at a defined orientation with the symmetry axis of the putative N-terminal beta-barrel tilted about 45° from the membrane normal
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translocates from the cytosol to the membrane upon stimulation in female neutrophils
calcium binds to allosteric sites in the 5-LOX N-terminal polycystin-1/lipoxygenase/alpha-toxin (PLAT) domain, promoting attachment to the membrane via conserved tryptophan residues that embed into the lipid bilayer
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polymorphonuclear leukocytes: translocation of cytosolic enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein
being a mobile enzyme, 5-LO migrates from the cytosol to the nuclear envelope, located mainly in the soluble part of the nucleus
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in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein
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alvelolar macrophages nuclear soluble enzyme moves to the nucear envelope where it interacts with 5-lipoxygenase-activating protein
accumulation of wild-type 5-LO in the soluble compartment of the nucleus, regardless of FLAP co-expression
wild-type enzyme 5-LO1 is primarily in the nucleoplasm, role for residue W102 in nuclear targeting of enzyme 5-LO1
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Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein, FLAP
soluble fraction, translocation to the nuclear envelope upon cell activation by Ca2+
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in stimulated HEK293/T and COS-7 cells the activated 5-lipoxygenase appears mainly at the nuclear envelope
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resides in a nuclear soluble compartment associated with chromatin. In male neutrophils, a substantial part of 5-lipoxygenase is located at the perinuclear region already in resting cells, only marginally redistributes upon stimulation
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5-LO associates with a nuclear fraction only when differentiated cells are primed with phorbol ester and stimulated with ionophore
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soluble fraction, translocation to the nuclear envelope upon cell activation by Ca2+
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in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein
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alvelolar macrophages nuclear soluble enzyme moves to the nucear envelope where it interacts with 5-lipoxygenase-activating protein
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soluble fraction, translocation to the nuclear envelope upon cell activation by Ca2+
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resides in a nuclear soluble compartment associated with chromatin
localization of enzyme and reactions, and activation in the cell, overview
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additional information
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upon cell activation, cytosolic and nuclear enzyme translocates the nuclear envelope, where it interacts with phospholipase A2, making free arachidonate available for 5-LO, and with 5-LO activating protein, i.e. FLAP
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additional information
Ca2+-mediated translocation from plasma membranes to nucleus upon cell stimulation, the translocation of 5-LOX is assisted by a 5-LOX activating protein (FLAP)
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additional information
immunohistochemic analysis of subcellular localization of recombinant wild-type and mutant enzymes in HeLa and HEK-293 cells
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additional information
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immunohistochemic analysis of subcellular localization of recombinant wild-type and mutant enzymes in HeLa and HEK-293 cells
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additional information
upon stimulation of neutrophils with A23187, cytosolic 5-LOX is translocated to the nucleus, and this is concentration-dependently inhibited by BRP-7
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additional information
wild-type 5-LO is localized in the nucleus whereas all natural truncation mutant isoforms and point mutant S271A are located in the cytosol. Treatment of the cells with sorbitol or KN-93/SB203580 changes the localization of the wild-type enzyme to the cytosol
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additional information
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wild-type 5-LO is localized in the nucleus whereas all natural truncation mutant isoforms and point mutant S271A are located in the cytosol. Treatment of the cells with sorbitol or KN-93/SB203580 changes the localization of the wild-type enzyme to the cytosol
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additional information
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localization of enzyme and reactions, and activation in the cell, overview
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additional information
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localization of enzyme and reactions, and activation in the cell, overview
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