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1.13.11.34: arachidonate 5-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
=
leukotriene A4
+
H2O

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.34 arachidonate 5-lipoxygenase

Localization

Localization on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
mainly
Manually annotated by BRENDA team
-
when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane
Manually annotated by BRENDA team
iron removal is able to affect the membrane binding properties of the enzyme, molecular dynamics simulations, overview
Manually annotated by BRENDA team
additional information