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Literature summary for 1.13.11.34 extracted from
- Metabolism of unsaturated fatty acids by RBL-1 5-lipoxygenase: influence of substrate solubility and product inactivation (1989), Biochim. Biophys. Acta, 1005, 170-176.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 11,14,17-Eicosatrienoic acid | IC50: 0.015 mM | Rattus norvegicus |  |
| 4,7,10,13,16,19-docosahexaenoic acid | IC50: 0.0013 mM | Rattus norvegicus | |
| 8,11,14-eicosatrienoic acid | IC50: 0.00219 mM | Rattus norvegicus | |
| arachidonic acid | induces time-dependent enzyme inactivation at concentrations 100fold lower than the Km-value, IC50: 0.00023 mM; substrate inhibition | Rattus norvegicus | |
| eicosapentaenoic acid | induces time-dependent enzyme inactivation at concentrations 100fold lower than the Km-value, IC50: 0.00065 mM; substrate inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0258 | - |
arachidonic acid | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukemia cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Rattus norvegicus | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0137 | - |
arachidonic acid | - |
Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00023 | - |
induces time-dependent enzyme inactivation at concentrations 100fold lower than the Km-value, IC50: 0.00023 mM | Rattus norvegicus | arachidonic acid | |
| 0.00065 | - |
induces time-dependent enzyme inactivation at concentrations 100fold lower than the Km-value, IC50: 0.00065 mM | Rattus norvegicus | eicosapentaenoic acid | |
| 0.0013 | - |
IC50: 0.0013 mM | Rattus norvegicus | 4,7,10,13,16,19-docosahexaenoic acid | |
| 0.00219 | - |
IC50: 0.00219 mM | Rattus norvegicus | 8,11,14-eicosatrienoic acid | |
| 0.015 | - |
IC50: 0.015 mM | Rattus norvegicus | 11,14,17-Eicosatrienoic acid | |
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