Literature summary for 1.13.11.34 extracted from

Aparoy, P.; Reddy, R.N.; Guruprasad, L.; Reddy, M.R.; Reddanna, P.
Homology modeling of 5-lipoxygenase and hints for better inhibitor design (2008), J. Comput. Aided Mol. Des., 22, 611-619.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(benzyloxy)hept-2-yn-4-ol	forms three hydrogen bonds with 5-lipoxygenase	Solanum tuberosum
1-[(4methylbenzyl)oxy]hept-2-yn-4-ol	is more potent than 1-(benzyloxy)hept-2-yn-4-ol to 5-lipoxygenase	Solanum tuberosum
additional information	[(hept-2-yn-1-ylsulfanyl)methyl]benzene is no inhibitor, there are no strong interactions to stabilize the compound in the 5-lipoxygenase active site	Solanum tuberosum
nordihydroguaiaretic acid	is more potent inhibitor of 5-lipoxygenase than 1-(benzyloxy)hept-2-yn-4-ol	Solanum tuberosum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	Asn720 is present in the fifth coordination position of iron	Solanum tuberosum

Organism

Organism	UniProt	Comment	Textmining
Solanum tuberosum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	5-lipoxygenase has a two-domain structure, the small N-terminal beta-barrel domain and a larger catalytic domain containing a single atom of non-heme iron coordinating with His525, His530, His716 and Ile864	Solanum tuberosum	?	-	?

Synonyms

Synonyms	Comment	Organism
5-lipoxygenase	-	Solanum tuberosum
5-LOX	-	Solanum tuberosum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0015	-	-	Solanum tuberosum	nordihydroguaiaretic acid
0.045	-	-	Solanum tuberosum	1-[(4methylbenzyl)oxy]hept-2-yn-4-ol
0.76	-	-	Solanum tuberosum	1-(benzyloxy)hept-2-yn-4-ol

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Release 2023.1 (January 2023)