1.13.11.20: cysteine dioxygenase

This is an abbreviated version!
For detailed information about cysteine dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.20

Reaction

L-cysteine
+
O2
=
3-sulfinoalanine

Synonyms

3-mercaptopropionate dioxygenase, Arg-type CDO, BsCDO, CDO, CDO1, CDO2, CdoA, CdoB, cysteine dioxygenase, cysteine oxidase, Fe(II) cysteine dioxygenase, H16_A1614, H16_B1863, oxygenase, cysteine di-

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.20 cysteine dioxygenase

Reference

Reference on EC 1.13.11.20 - cysteine dioxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hosokawa, Y.; Matsumoto, A.; Oka, J.; Itakura, H.; Yamaguchi, K.
Isolation and characterization of a cDNA for rat liver cysteine dioxygenase
Biochem. Biophys. Res. Commun.
168
473-478
1990
Rattus norvegicus
Manually annotated by BRENDA team
Yamaguchi, K.; Hosokawa, Y.
Cysteine dioxygenase
Methods Enzymol.
143
395-403
1987
Rattus norvegicus
Manually annotated by BRENDA team
Kumar, V.; Maresca, B.; Sacco, M.; Goewert, R.; Kobayashi, G.S.; Medoff, G.
Purification and characterization of a cysteine dioxygenase from the yeast phase of Histoplasma capsulatum
Biochemistry
22
762-768
1983
Histoplasma capsulatum
Manually annotated by BRENDA team
Lombardini, J.B.; Singer, T.P.; Boyer, P.D.
Cystein oxygenase. II. Studies on the mechanism of the reaction with 18oxygen
J. Biol. Chem.
244
1172-1175
1969
Rattus norvegicus
Manually annotated by BRENDA team
Kohashi, N.; Yamaguchi, K.; Hosokawa, Y.; Kori, Y.; Fujii, O.; Ueda, I.
Dietary control of cysteine dioxygenase in rat liver
J. Biochem.
84
159-168
1978
Rattus norvegicus
Manually annotated by BRENDA team
Sakakibara, S.; Yamaguchi, K.; Hosokawa, Y.; Kohashi, N.; Ueda, I.; Sakamoto, Y.
Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)
Biochim. Biophys. Acta
422
273-279
1976
Rattus norvegicus
Manually annotated by BRENDA team
Sakakibara, S.; Yamaguchi, K.; Ueda, I.
Two components of cysteine oxidase in rat liver
Biochem. Biophys. Res. Commun.
52
1093-1099
1973
Rattus norvegicus
Manually annotated by BRENDA team
Yamaguchi, K.; Hosokawa, Y.; Kohashi, N.; Kori, Y.; Sakakibara, S.; Ueda, I.
Rat liver cysteine dioxygenase (cysteine oxidase). Further purification, characterization, and analysis of the activation and inactivation
J. Biochem.
83
479-491
1978
Rattus norvegicus
Manually annotated by BRENDA team
Bagley, P.J.; Stipanuk, M.H.
The activities of rat hepatic cysteine dioxygenase and cysteinesulfinate decarboxylase are regulated in a reciprocal manner in response to dietary casein level
J. Nutr.
124
2410-2421
1994
Rattus norvegicus
Manually annotated by BRENDA team
McCann, K.P.; Akbari, M.T.; Williams, A.C.; Ramsden, D.B.
Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA
Biochim. Biophys. Acta
1209
107-110
1994
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Bagley, P.J.; Stipanuk, M.H.
Rats fed a low protein diet supplemented with sulfur amino acids have increased cysteine dioxygenase activity and increased taurine production in hepatocytes
J. Nutr.
125
933-940
1995
Rattus norvegicus
Manually annotated by BRENDA team
Bagley, P.J.; Hirschberger, L.L.; Stipanuk, M.H.
Evaluation and modification of an assay procedure for cysteine dioxygenase activity: high-performance liquid chromatography method for measurement of cysteine sulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism
Anal. Biochem.
227
40-48
1995
Rattus norvegicus
Manually annotated by BRENDA team
Parsons, R.B.; Ramsden, D.B.; Waring, R.H.; Barber, P.C.; Williams, A.C.
Hepatic localization of rat cysteine dioxygenase
J. Hepatol.
29
595-602
1998
Rattus norvegicus
Manually annotated by BRENDA team
Kwon, Y.H.; Stipanuk, M.H.
Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes
Am. J. Physiol. Endocrinol. Metab.
280
E804-815
2001
Rattus norvegicus
Manually annotated by BRENDA team
Parsons, R.B.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
Cysteine dioxygenase: regional localization of protein and mRNA in rat brain
J. Neurosci. Res.
65
78-84
2001
Rattus norvegicus
Manually annotated by BRENDA team
Hirschberger, L.L.; Daval, S.; Stover, P.J.; Stipanuk, M.H.
Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification
Gene
277
153-161
2001
Mus musculus, Mus musculus (P60334)
Manually annotated by BRENDA team
Wilkinson, L.J.; Waring, R.H.
Cysteine dioxygenase: modulation of expression in human cell lines by cytokines and control of sulphate production
Toxicol. In Vitro
16
481-483
2002
Homo sapiens
Manually annotated by BRENDA team
Stipanuk, M.H.; Hirschberger, L.L.; Londono, M.P.; Cresenzi, C.L.; Yu, A.F.
The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver
Am. J. Physiol.
286
E439-448
2004
Rattus norvegicus
Manually annotated by BRENDA team
Stipanuk, M.H.; Londono, M.; Hirschberger, L.L.; Hickey, C.; Thiel, D.J.; Wang, L.
Evidence for expression of a single distinct form of mammalian cysteine dioxygenase
Amino Acids
26
99-106
2004
Rattus norvegicus
Manually annotated by BRENDA team
Satsu, H.; Terasawa, E.; Hosokawa, Y.; Shimizu, M.
Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells
Biochem. J.
375
441-447
2003
Homo sapiens
Manually annotated by BRENDA team
Chai, S.C.; Jerkins, A.A.; Banik, J.J.; Shalev, I.; Pinkham, J.L.; Uden, P.C.; Maroney, M.J.
Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase
J. Biol. Chem.
280
9865-9869
2005
Rattus norvegicus
Manually annotated by BRENDA team
Cresenzi, C.L.; Lee, J.I.; Stipanuk, M.H.
Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats
J. Nutr.
133
2697-2702
2003
Rattus norvegicus
Manually annotated by BRENDA team
Millard, J.; Parsons, R.B.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica
Mol. Pathol.
56
270-274
2003
Homo sapiens
Manually annotated by BRENDA team
Dominy, J.E.; Simmons, C.R.; Karplus, P.A.; Gehring, A.M.; Stipanuk, M.H.
Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria
J. Bacteriol.
188
5561-5569
2006
Bacillus cereus, Bacillus cereus (Q81CX4), Bacillus cereus DSM 31 (Q81CX4), Bacillus subtilis, Bacillus subtilis (O32085), no activity in Nostoc sp., Rattus norvegicus (P21816), Streptomyces coelicolor (O50490), Streptomyces coelicolor (Q9KZL0), Streptomyces coelicolor A3(2) SCO3035 (Q9KZL0), Streptomyces coelicolor A3(2) SCO5772 (O50490)
Manually annotated by BRENDA team
Chai, S.C.; Bruyere, J.R.; Maroney, M.J.
Probes of the catalytic site of cysteine dioxygenase
J. Biol. Chem.
281
15774-15779
2006
Rattus norvegicus
Manually annotated by BRENDA team
Simmons, C.R.; Liu, Q.; Huang, Q.; Hao, Q.; Begley, T.P.; Karplus, P.A.; Stipanuk, M.H.
Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation
J. Biol. Chem.
281
18723-18733
2006
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Ye, S.; Wu, X.; Wei, L.; Tang, D.; Sun, P.; Bartlam, M.; Rao, Z.
An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor
J. Biol. Chem.
282
3391-3402
2007
Homo sapiens, Homo sapiens (Q16878)
Manually annotated by BRENDA team
McCoy, J.G.; Bailey, L.J.; Bitto, E.; Bingman, C.A.; Aceti, D.J.; Fox, B.G.; Phillips, G.N.
Structure and mechanism of mouse cysteine dioxygenase
Proc. Natl. Acad. Sci. USA
103
3084-3089
2006
Mus musculus, Mus musculus (P60334)
Manually annotated by BRENDA team
Simmons, C.R.; Hirschberger, L.L.; Machi, M.S.; Stipanuk, M.H.
Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels
Protein Expr. Purif.
47
74-81
2006
Rattus norvegicus
Manually annotated by BRENDA team
Dominy, J.E.; Hwang, J.; Stipanuk, M.H.
Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells
Am. J. Physiol. Endocrinol. Metab.
293
E62-E69
2007
Rattus norvegicus
Manually annotated by BRENDA team
Oien, D.B.; Moskovitz, J.
Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine dioxygenase
Biochem. Biophys. Res. Commun.
352
556-559
2007
Mus musculus
Manually annotated by BRENDA team
Pierce, B.S.; Gardner, J.D.; Bailey, L.J.; Brunold, T.C.; Fox, B.G.
Characterization of the nitrosyl adduct of substrate-bound mouse cysteine dioxygenase by electron paramagnetic resonance: electronic structure of the active site and mechanistic implications
Biochemistry
46
8569-8578
2007
Mus musculus, Mus musculus (P60334)
Manually annotated by BRENDA team
Dominy, J.E.; Hwang, J.; Guo, S.; Hirschberger, L.L.; Zhang, S.; Stipanuk, M.H.
Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity
J. Biol. Chem.
283
12188-12201
2008
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Ueki, I.; Stipanuk, M.H.
3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways
J. Nutr.
139
207-214
2009
Rattus norvegicus
Manually annotated by BRENDA team
Stipanuk, M.H.; Ueki, I.; Dominy, J.E.; Simmons, C.R.; Hirschberger, L.L.
Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels
Amino Acids
37
55-63
2009
Rattus norvegicus
Manually annotated by BRENDA team
Honjoh, K.I.; Matsuura, K.; Machida, T.; Nishi, K.; Nakao, M.; Yano, T.; Miyamoto, T.; Iio, M.
Enhancement of menadione stress tolerance in yeast by accumulation of hypotaurine and taurine: co-expression of cDNA clones, from Cyprinus carpio, for cysteine dioxygenase and cysteine sulfinate decarboxylase in Saccharomyces cerevisiae
Amino Acids
38
1173-1183
2009
Cyprinus carpio, Cyprinus carpio (Q2PFL1), Cyprinus carpio (Q2PFL2)
Manually annotated by BRENDA team
de Visser, S.
Elucidating enzyme mechanism and intrinsic chemical properties of short-lived intermediates in the catalytic cycles of cysteine dioxygenase and taurine/alpha-ketoglutarate dioxygenase
Coord. Chem. Rev.
253
754-768
2009
Homo sapiens (Q16878)
-
Manually annotated by BRENDA team
Bruland, N.; Wuebbeler, J.H.; Steinbuechel, A.
3-mercaptopropionate dioxygenase, a cysteine dioxygenase homologue, catalyzes the initial step of 3-mercaptopropionate catabolism in the 3,3-thiodipropionic acid-degrading bacterium variovorax paradoxus
J. Biol. Chem.
284
660-672
2009
Variovorax paradoxus
Manually annotated by BRENDA team
Kleffmann, T.; Jongkees, S.A.; Fairweather, G.; Wilbanks, S.M.; Jameson, G.N.
Mass-spectrometric characterization of two posttranslational modifications of cysteine dioxygenase
J. Biol. Inorg. Chem.
14
913-921
2009
Rattus norvegicus
Manually annotated by BRENDA team
Siakkou, E.; Wilbanks, S.M.; Jameson, G.N.
Simplified cysteine dioxygenase activity assay allows simultaneous quantitation of both substrate and product
Anal. Biochem.
405
127-131
2010
Rattus norvegicus
Manually annotated by BRENDA team
Gardner, J.D.; Pierce, B.S.; Fox, B.G.; Brunold, T.C.
Spectroscopic and computational characterization of substrate-bound mouse cysteine dioxygenase: nature of the ferrous and ferric cysteine adducts and mechanistic implications
Biochemistry
49
6033-6041
2010
Mus musculus
Manually annotated by BRENDA team
Kasperova, A.; Kunert, J.; Horynova, M.; Weigl, E.; Sebela, M.; Lenobel, R.; Raska, M.
Isolation of recombinant cysteine dioxygenase protein from Trichophyton mentagrophytes
Mycoses
54
e456-462
2011
Trichophyton mentagrophytes (D1MF76), Trichophyton mentagrophytes, Trichophyton mentagrophytes TM-10 (D1MF76)
Manually annotated by BRENDA team
Crawford, J.A.; Li, W.; Pierce, B.S.
Single turnover of substrate-bound ferric cysteine dioxygenase with superoxide anion: enzymatic reactivation, product formation, and a transient intermediate
Biochemistry
50
10241-10253
2011
Mus musculus
Manually annotated by BRENDA team
Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.N.L.
A strongly bound high-spin iron(II) coordinates cysteine and homocysteine in cysteine dioxygenase
Biochemistry
51
257-264
2012
Rattus norvegicus
Manually annotated by BRENDA team
Blaesi, E.J.; Gardner, J.D.; Fox, B.G.; Brunold, T.C.
Spectroscopic and computational characterization of the NO adduct of substrate-bound Fe(II) cysteine dioxygenase: insights into the mechanism of O2 activation
Biochemistry
52
6040-6051
2013
Mus musculus
Manually annotated by BRENDA team
Souness, R.J.; Kleffmann, T.; Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.B.; Jameson, G.N.
Mechanistic implications of persulfenate and persulfide binding in the active site of cysteine dioxygenase
Biochemistry
52
7606-7617
2013
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Siakkou, E.; Rutledge, M.T.; Wilbanks, S.M.; Jameson, G.N.L.
Correlating crosslink formation with enzymatic activity in cysteine dioxygenase
Biochim. Biophys. Acta
1814
2003-2009
2011
Rattus norvegicus
Manually annotated by BRENDA team
Che, X.; Gao, J.; Liu, Y.; Liu, C.
Metal vs. chalcogen competition in the catalytic mechanism of cysteine dioxygenase
J. Inorg. Biochem.
122
1-7
2013
Rattus norvegicus
Manually annotated by BRENDA team
Driggers, C.M.; Cooley, R.B.; Sankaran, B.; Hirschberger, L.L.; Stipanuk, M.H.; Karplus, P.A.
Cysteine dioxygenase structures from pH 4 to 9: consistent Cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH
J. Mol. Biol.
425
3121-3136
2013
Homo sapiens
Manually annotated by BRENDA team
Kasperova, A.; Kunert, J.; Raska, M.
The possible role of dermatophyte cysteine dioxygenase in keratin degradation
Med. Mycol.
51
449-454
2013
Bacillus sp. (in: Bacteria), Candida albicans, Histoplasma capsulatum, Mammalia, Streptomyces sp., Trichophyton mentagrophytes, Trichophyton rubrum
Manually annotated by BRENDA team
Arjune, S.; Schwarz, G.; Belaidi, A.A.
Involvement of the Cys-Tyr cofactor on iron binding in the active site of human cysteine dioxygenase
Amino Acids
47
55-63
2015
Homo sapiens, Homo sapiens (Q16878)
Manually annotated by BRENDA team
Wenning, L.; Stoeveken, N.; Wuebbeler, J.H.; Steinbuechel, A.
Substrate and cofactor range differences of two cysteine dioxygenases from Ralstonia eutropha H16
Appl. Environ. Microbiol.
82
910-921
2015
Cupriavidus necator (Q0K029), Cupriavidus necator (Q0KB75), Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (Q0K029), Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (Q0KB75)
Manually annotated by BRENDA team
Davies, C.G.; Fellner, M.; Tchesnokov, E.P.; Wilbanks, S.M.; Jameson, G.N.
The Cys-Tyr cross-link of cysteine dioxygenase changes the optimal pH of the reaction without a structural change
Biochemistry
53
7961-7968
2014
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Pietra, F.
On the dynamical behavior of the cysteine dioxygenase-L-cysteine complex in the presence of free dioxygen and L-cysteine
Chem. Biodivers.
14
e1700290
2017
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Tchesnokov, E.P.; Faponle, A.S.; Davies, C.G.; Quesne, M.G.; Turner, R.; Fellner, M.; Souness, R.J.; Wilbanks, S.M.; de Visser, S.P.; Jameson, G.N.
An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
Chem. Commun. (Camb.)
52
8814-8817
2016
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Sallmann, M.; Kumar, S.; Chernev, P.; Nehrkorn, J.; Schnegg, A.; Kumar, D.; Dau, H.; Limberg, C.; de Visser, S.P.
Structure and mechanism leading to formation of the cysteine sulfinate product complex of a biomimetic cysteine dioxygenase model
Chemistry
21
7470-7479
2015
Homo sapiens (Q16878)
Manually annotated by BRENDA team
Faponle, A.S.; Seebeck, F.P.; de Visser, S.P.
Sulfoxide synthase versus cysteine dioxygenase reactivity in a nonheme iron enzyme
J. Am. Chem. Soc.
139
9259-9270
2017
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Driggers, C.M.; Kean, K.M.; Hirschberger, L.L.; Cooley, R.B.; Stipanuk, M.H.; Karplus, P.A.
Structure-based insights into the role of the Cys-Tyr crosslink and inhibitor recognition by mammalian cysteine dioxygenase
J. Mol. Biol.
428
3999-4012
2016
Rattus norvegicus (P21816)
Manually annotated by BRENDA team
Driggers, C.M.; Hartman, S.J.; Karplus, P.A.
Structures of Arg- and Gln-type bacterial cysteine dioxygenase homologs
Protein Sci.
24
154-161
2015
Bacillus subtilis 168 (O32085), Bacillus subtilis, Bacillus subtilis (O32085)
Manually annotated by BRENDA team