1.13.11.20: cysteine dioxygenase

This is an abbreviated version!
For detailed information about cysteine dioxygenase, go to the full flat file.

Reaction

Synonyms

3-mercaptopropionate dioxygenase, 3MDO, ADO, Arg-type CDO, BsCDO, CDO, CDO1, CDO2, CdoA, CdoB, cysteine dioxygenase, cysteine dioxygenase type 1, cysteine oxidase, Fe(II) cysteine dioxygenase, H16_A1614, H16_B1863, NP_251292, oxygenase, cysteine di-, PA2602, PCO1, PCO4

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.20 cysteine dioxygenase

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Results	in table
42	Activating Compound
5409	AA Sequence
3	Application
1	CAS Registry Number
37	Cloned(Commentary)
11	Cofactor
15	Crystallization (Commentary)
131	Disease/ Diagnostics
5	Expression
64	General Information
1	General Stability
95	Inhibitors
16	kcat/KM [mM/s]
3	Ki Value [mM]
46	KM Value [mM]
5	Localization
63	Metals/Ions
26	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
114	Organism
3	Oxidation Stability
7	Pathway
85	PDB ID
24	pH Optimum
1	pH Range
4	pI Value
8	Posttranslational Modification
27	Protein Variants
32	Purification (Commentary)
10	Reaction
4	Reaction Type
104	Reference
65	Source Tissue
23	Specific Activity [micromol/min/mg]
4	Storage Stability
128	Substrates and Products (Substrate)
23	Subunits
85	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
31	Turnover Number [1/s]

Application

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Application on EC 1.13.11.20 - cysteine dioxygenase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

2 entries

synthesis

Homo sapiens

Q16878

the mechanism of cysteine dioxygenase-catalyzed C-F bond cleavage of 3,5-difluoro-1-tyrosine contains four elementary steps: H-abstraction, C-S bond formation, F-transfer, and C-F bond cleavage. C-F bond cleavage is the rate-determining step with an energy barrier of 18.8 kcal/mol

764464

medicine

Mus musculus

-

lack of methionine sulfoxide reductase MsrA in liver of MsrA -/- mice leads to a significant drop in the cellular level of thiol groups and lowers the level of cysteine dioxygenase expression. Following selenium deficient diet applied to decrease the expression levels of selenoproteins like MsrB, the latter effect is maintained while the basal levels of thiol decreased in both wild-type strains and strains deficient for methionine dioxygenase

684830

medicine

Homo sapiens

Q16878

CDO1 is preferentially silenced by promoter methylation in human non-small cell lung cancers harboring mutations in KEAP1, the negative regulator of transcription factor NRF2. CDO1 silencing promotes proliferation of non-small cell lung cancer cells by limiting the futile metabolism of cysteine to the wasteful and toxic byproducts CSA and sulfite, and depletion of cellular NADPH

764569