1.13.11.20: cysteine dioxygenase

This is an abbreviated version!
For detailed information about cysteine dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.20

Reaction

L-cysteine
+
O2
=
3-sulfinoalanine

Synonyms

3-mercaptopropionate dioxygenase, Arg-type CDO, BsCDO, CDO, CDO1, CDO2, CdoA, CdoB, cysteine dioxygenase, cysteine oxidase, Fe(II) cysteine dioxygenase, H16_A1614, H16_B1863, oxygenase, cysteine di-

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.20 cysteine dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.20 - cysteine dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
2-amino-ethanethiol
2-mercaptoethanol
-
2-oxoglutarate
-
-
2-sulfanyl-ethanol
3,3'-thiodipropionic acid
-
-
3-Mercaptopropionate
complete inhibition at 0.05 mM
3-Mercaptopropionic acid
-
-
3-sulfanyl-propionic acid
3-sulfinopropionic acid
-
-
8-hydroxyquinoline
alpha-ketoglutarate
-
alpha-ketoglutarate inhibits cysteine dioxygenase with 50% inhibition at 6.8 mM
aspartic acid
-
aspartic acid decreases enzyme activity to 50% at a concentration of 1.5 mM. Replacing the sulfydryl by the uncharged hydroxyl group of serine does not affect enzyme activity.
azide
Bathocuproine sulfonate
bathophenanthroline sulfonate
Carboxyethyl-L-cysteine
-
53% inhibition at 1 mM
carboxymethyl-L-cysteine
-
37% inhibition at 1 mM
CdCl2
-
cells transfected with wild-type enzyme show an enhanced sensitivity to CdCl2 that is limited to cells cultured in medium with cysteine levels of 0.1 and 0.3mM
Cu2+
-
90% inhibition at 0.01 mM, 100% inhibition at 0.1 mM
cyanide
-
inhibits with a 50% actvity reduction at 2.7 mM
cysteamine
cystine
-
42% inhibition at 5 mM
cytokine tumor necrosis factor-alpha
-
also TNF-alpha, down-regulation observed in hepatic and brain cells
-
D-Cys
-
competitive inhibitor, binding structure, overview
D-cysteine
D-cysteinesulfinate
-
34.4% inhibition in hepatocytes from rats fed a low casein diet, 71.8% inhibition in hepatocytes from rats fed a moderate casein diet, 64.4% inhibition in hepatocytes from rats fed a high casein diet
diethyldithiocarbamate
DL-homocysteine
DL-homocystine
-
47% inhibition at 5 mM
DL-propargylglycine
ethyl xanthate
44% inhibition at 0.004 mM
Glutarate
-
-
homocysteine
L-cysteine
-
concentrations of cysteine of 2 mM and above are inhibitory in assays of purified cysteine dioxygenase
Mercaptopropionic acid
-
mercaptopropionic acid at a concentration of 1.2 mM inhibits cysteine dioxygenase activity by 50%
N-acetyl-L-cysteine
-
35% inhibition at 10 mM
Neocuproine
-
with protein-A: 18% inhibition at 0.1 mM, without protein-A: slight activation at 0.1 mM
o-phenanthroline
S-carboxymethylcysteine
-
S-carboxymethylcysteine exhibits 50% inhibition at a concentration of 2.3 mM
S-methyl-L-cysteine
-
34% inhibition at 1 mM
sodium ethylxanthate
11% inhibition at 0.004 mM
-
thiosulfate
-
competitive inhibitor, binding structure, overview
transforming growth factor-beta
-
also TGF-beta, down-regulation observed in hepatic and brain cells
-
additional information
-