1.13.11.20: cysteine dioxygenase
This is an abbreviated version!
For detailed information about cysteine dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.20
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1.13.11.20
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taurine
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sulfinic
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non-heme
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hypotaurine
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cysteinesulfinate
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cysteamine
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cystathionine
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3-mercaptopropionate
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cys-tyr
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taut
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adenosyltransferase
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desulfhydration
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2-his-1-carboxylate
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gamma-lyase
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cupins
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2-aminoethanethiol
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medicine
- 1.13.11.20
- taurine
-
sulfinic
-
non-heme
- hypotaurine
-
cysteinesulfinate
- cysteamine
- cystathionine
- 3-mercaptopropionate
-
cys-tyr
-
taut
-
adenosyltransferase
-
desulfhydration
-
2-his-1-carboxylate
-
gamma-lyase
-
cupins
- 2-aminoethanethiol
- medicine
Reaction
Synonyms
3-mercaptopropionate dioxygenase, 3MDO, ADO, Arg-type CDO, BsCDO, CDO, CDO1, CDO2, CdoA, CdoB, cysteine dioxygenase, cysteine dioxygenase type 1, cysteine oxidase, Fe(II) cysteine dioxygenase, H16_A1614, H16_B1863, NP_251292, oxygenase, cysteine di-, PA2602, PCO1, PCO4
ECTree
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Source Tissue
Source Tissue on EC 1.13.11.20 - cysteine dioxygenase
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androgen-dependent CDO expression is highest in the caput epididymidis
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hepatoblastoma cells, enzyme expression is up-regulated under hypertonic conditions
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CDO is found specifically in the mucus-secreting goblet cells
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in Streptomyces spp. CDO is expressed in the vegetative state, and an increase in its activity is detected after the initiation of conidia production
additional information
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neuron, including the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum, the regional localization varies, with high levels of expression in the hippocampus, the dentate gyrus, the outer cortices of the brain, and the substantia nigra
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primary cell culture, high enzyme activity in cysteine rich medium
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lack of methionine sulfoxide reductase MsrA in liver of MsrA -/- mice leads to a significant drop in the cellular level of thiol groups and lowers the level of cysteine dioxygenase expression. Following selenium deficient diet applied to decrease the expression levels of selenoproteins like MsrB, the latter effect is maintained while the basal levels of thiol decreased in both wild-type strains and strains deficient for methionine dioxygenase
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439541, 439542, 439544, 439545, 439546, 439547, 439548, 439549, 439550, 439551, 439552, 439553, 439554, 657515, 657523, 659767, 674569, 693792, 695529
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alveolar epithelial cells, no enzyme detected in smooth muscle cells lining the alveoli or in blood vessels within the surrounding tissue
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intense staining for CDO in ductal cells of pregnant rats but not in other mammary epithelial cells or in ductal cells of non-pregnant rats
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in Bacillus and Streptomyces spp. CDO is expressed in the vegetative state, and an increase in its activity is detected after the initiation of conidia production
additional information
no enzyme message observed in the spleen, heart or skeletal muscle
additional information
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no enzyme message observed in the spleen, heart or skeletal muscle
additional information
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distribution is found to be centrilobular and does not alter when the enzyme is induced with cysteine or methionine