BRENDA - Enzyme Database show
show all sequences of 1.13.11.20

Evaluation and modification of an assay procedure for cysteine dioxygenase activity: high-performance liquid chromatography method for measurement of cysteine sulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism

Bagley, P.J.; Hirschberger, L.L.; Stipanuk, M.H.; Anal. Biochem. 227, 40-48 (1995)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Fe2+
stimulates
Rattus norvegicus
NAD+
stimulates
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Rattus norvegicus
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
Sprague-Dawley strain male rats; Wistar strain male rats
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
enzyme activity measured in liver homogenate, supernatant and activated supernatant with and without addition of Fe2+, NAD+ and NH2OH. Comparison of enzyme activity in liver from Wistar vs Sprague-Dawley rats in the soluble and particulate fractions of liver homogenized in sucrose vs Mes buffer. Comparison of enzyme activity in hepatocytes isolated from rats fed diets with either 100 or 300 g casein per kg
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-cysteine + O2
-
439552
Rattus norvegicus
3-sulfino-L-alanine
-
439552
Rattus norvegicus
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.1
-
-
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
NAD+ does not appear to be a cofactor, the role of NAD+ in the stimulation of the enzyme is unclear
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Fe2+
stimulates
Rattus norvegicus
NAD+
stimulates
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
NAD+ does not appear to be a cofactor, the role of NAD+ in the stimulation of the enzyme is unclear
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Rattus norvegicus
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
enzyme activity measured in liver homogenate, supernatant and activated supernatant with and without addition of Fe2+, NAD+ and NH2OH. Comparison of enzyme activity in liver from Wistar vs Sprague-Dawley rats in the soluble and particulate fractions of liver homogenized in sucrose vs Mes buffer. Comparison of enzyme activity in hepatocytes isolated from rats fed diets with either 100 or 300 g casein per kg
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-cysteine + O2
-
439552
Rattus norvegicus
3-sulfino-L-alanine
-
439552
Rattus norvegicus
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.1
-
-
Rattus norvegicus
Other publictions for EC 1.13.11.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742253
Pietra
On the dynamical behavior of ...
Rattus norvegicus
Chem. Biodivers.
14
e1700290
2017
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2
2
-
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742755
Faponle
Sulfoxide synthase versus cys ...
Rattus norvegicus
J. Am. Chem. Soc.
139
9259-9270
2017
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1
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2
2
-
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742264
Tchesnokov
An iron-oxygen intermediate f ...
Rattus norvegicus
Chem. Commun. (Camb.)
52
8814-8817
2016
-
-
1
-
1
-
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1
-
1
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1
-
1
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1
1
1
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3
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1
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1
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1
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3
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1
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1
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743088
Driggers
Structure-based insights into ...
Rattus norvegicus
J. Mol. Biol.
428
3999-4012
2016
1
-
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1
3
-
4
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1
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4
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1
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1
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2
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2
2
-
-
-
741585
Arjune
Involvement of the Cys-Tyr co ...
Homo sapiens
Amino Acids
47
55-63
2015
-
-
1
-
1
-
3
3
-
1
-
1
-
3
-
1
-
-
-
-
-
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1
-
1
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1
1
-
-
1
-
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1
1
-
1
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3
-
3
-
1
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1
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1
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1
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1
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1
1
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741704
Wenning
Substrate and cofactor range ...
Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Appl. Environ. Microbiol.
82
910-921
2015
-
-
1
-
-
-
7
3
-
6
1
4
-
4
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1
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8
2
1
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3
2
-
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2
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2
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8
-
3
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8
1
4
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2
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8
2
2
-
-
3
2
-
-
2
-
2
2
-
3
3
742295
Sallmann
Structure and mechanism leadi ...
Homo sapiens
Chemistry
21
7470-7479
2015
-
-
-
-
-
-
-
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-
1
-
1
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1
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1
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3
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1
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3
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2
2
-
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-
743757
Driggers
Structures of Arg- and Gln-ty ...
Bacillus subtilis 168, Bacillus subtilis
Protein Sci.
24
154-161
2015
-
-
1
1
-
-
-
-
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1
-
2
-
6
-
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1
1
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2
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2
2
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-
741904
Davies
The Cys-Tyr cross-link of cys ...
Rattus norvegicus
Biochemistry
53
7961-7968
2014
-
-
1
1
1
-
-
4
-
1
-
1
-
1
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1
-
-
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-
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1
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3
2
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1
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1
1
1
1
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4
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1
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1
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1
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1
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-
3
2
-
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-
1
1
-
2
2
724391
Blaesi
Spectroscopic and computationa ...
Mus musculus
Biochemistry
52
6040-6051
2013
-
-
1
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1
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1
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1
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2
2
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724396
Souness
Mechanistic implications of pe ...
Rattus norvegicus
Biochemistry
52
7606-7617
2013
-
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1
1
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1
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1
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725651
Che
Metal vs. chalcogen competitio ...
Rattus norvegicus
J. Inorg. Biochem.
122
1-7
2013
-
-
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1
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2
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1
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1
1
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725720
Driggers
Cysteine dioxygenase structure ...
Homo sapiens
J. Mol. Biol.
425
3121-3136
2013
-
-
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1
-
-
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1
-
1
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1
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1
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1
-
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2
2
-
-
-
725864
Kasperova
The possible role of dermatoph ...
Bacillus sp. (in: Bacteria), Candida albicans, Histoplasma capsulatum, Mammalia, Streptomyces sp., Trichophyton mentagrophytes, Trichophyton rubrum
Med. Mycol.
51
449-454
2013
-
-
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7
-
10
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4
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7
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7
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4
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7
-
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15
15
-
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-
724336
Tchesnokov
A strongly bound high-spin iro ...
Rattus norvegicus
Biochemistry
51
257-264
2012
-
-
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1
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1
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713084
Kasperova
Isolation of recombinant cyste ...
Trichophyton mentagrophytes, Trichophyton mentagrophytes TM-10
Mycoses
54
e456-462
2011
-
-
1
-
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2
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5
-
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1
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724297
Crawford
Single turnover of substrate-b ...
Mus musculus
Biochemistry
50
10241-10253
2011
-
-
1
-
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1
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2
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1
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2
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1
1
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1
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1
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3
3
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724430
Siakkou
Correlating crosslink formatio ...
Rattus norvegicus
Biochim. Biophys. Acta
1814
2003-2009
2011
1
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1
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1
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5
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710849
Siakkou
Simplified cysteine dioxygenas ...
Rattus norvegicus
Anal. Biochem.
405
127-131
2010
-
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1
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711255
Gardner
Spectroscopic and computationa ...
Mus musculus
Biochemistry
49
6033-6041
2010
-
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1
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1
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2
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693792
Ueki
3T3-L1 adipocytes and rat adip ...
Rattus norvegicus
J. Nutr.
139
207-214
2009
1
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1
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695529
Stipanuk
Cysteine dioxygenase: a robust ...
Rattus norvegicus
Amino Acids
37
55-63
2009
-
-
1
1
5
-
1
-
1
-
1
1
-
2
-
-
-
-
-
7
-
-
2
1
-
-
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1
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1
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1
5
-
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1
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1
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1
1
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7
-
-
2
1
-
-
-
-
-
-
-
1
-
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-
-
-
-
695531
Honjoh
Enhancement of menadione stres ...
Cyprinus carpio
Amino Acids
38
1173-1183
2009
-
-
1
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1
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-
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1
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5
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1
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2
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2
1
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Kumar
Purification and characterizat ...
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Dietary control of cysteine di ...
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439546
Sakakibara
Purification and some properti ...
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Sakakibara
Two components of cysteine oxi ...
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Lombardini
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