Information on EC 3.1.2.20 - acyl-CoA hydrolase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
3.1.2.20
-
RECOMMENDED NAME
GeneOntology No.
acyl-CoA hydrolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + H2O = CoA + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of thioester
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
jasmonic acid biosynthesis
-
-
3-phenylpropionate degradation
-
-
acetate fermentation
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA hydrolase
Broad specificity for medium- to long-chain acyl-CoA. Insensitive to NAD+ (cf. EC 3.1.2.19 ADP-dependent medium-chain-acyl-CoA hydrolase)
CAS REGISTRY NUMBER
COMMENTARY hide
37270-64-7
EC 3.1.2.2
9025-87-0
EC 3.1.2.20
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
4 isoforms of different pI and MW; Peking or mallard duck
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
psychrophilic antarctic yeast, strain A19
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
beagle
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Z, dark-grown
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-
Manually annotated by BRENDA team
Z, dark-grown
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
crab eating
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain A3(2)
-
-
Manually annotated by BRENDA team
strain FR-008
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-
Manually annotated by BRENDA team
strain FR-008
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-
Manually annotated by BRENDA team
thioesterase II, gene pikAV
UniProt
Manually annotated by BRENDA team
strain XC229
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-
Manually annotated by BRENDA team
strain XC229
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-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
Acot2 enhances mitochondrial fatty acid oxidation
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-dihydroxybenzoyl-CoA + H2O
CoA + 2,3-dihydroxybenzoate
show the reaction diagram
-
-
-
-
?
2,3-dihydroxybenzoyl-EntB + H2O
EntB + 2,3-dihydroxybenzoate
show the reaction diagram
-
-
-
-
?
2,4-dihydroxybenzoyl-CoA + H2O
CoA + 2,4-dihydroxybenzoate
show the reaction diagram
-
-
-
-
?
2-butenoyl-CoA + H2O
CoA + 2-butenoate
show the reaction diagram
2-methylstearoyl-CoA + H2O
CoA + 2-methylstearate
show the reaction diagram
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
synthetic substrate
-
-
?
2-trans-decenoyl-CoA + H2O
CoA + 2-trans-decenoate
show the reaction diagram
-
-
-
?
3,4-dihydroxybenzoyl-CoA + H2O
CoA + 3,4-dihydroxybenzoate
show the reaction diagram
-
-
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
CoA + 3,4-dihydroxyphenylacetate
show the reaction diagram
-
-
-
?
3,5-cis-dodecadienoyl-CoA + H2O
CoA + 3,5-cis-dodecadienoic acid
show the reaction diagram
-
-
-
?
3,5-cis-tetradecadienoyl-CoA + H2O
CoA + 3,5-cis-tetradecadienoic acid
show the reaction diagram
-
-
-
?
3,5-dihydroxybenzoyl-CoA + H2O
CoA + 3,5-dihydroxybenzoate
show the reaction diagram
-
-
-
-
?
3,5-dihydroxyphenylacetyl-CoA + H2O
CoA + 3,5-dihydroxyphenylacetate
show the reaction diagram
-
-
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
CoA + 3-hydroxy-3-methyl glutarate
show the reaction diagram
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
show the reaction diagram
3-hydroxybenzoyl-CoA + H2O
CoA + 3-hydroxybenzoate
show the reaction diagram
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutanoate
show the reaction diagram
-
reaction at 4.3% the rate of acetoacetyl-CoA hydrolysis
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutyrate
show the reaction diagram
-
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
show the reaction diagram
3-hydroxyhexadecanoyl-CoA + H2O
CoA + 3-hydroxyhexadecanoate
show the reaction diagram
-
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
CoA + 3-hydroxyphenylacetate
show the reaction diagram
3-hydroxytetradecanoyl-CoA + H2O
CoA + 3-hydroxytetradecanoate
show the reaction diagram
-
-
-
?
3-oxodecanyl-CoA + H2O
CoA + 3-oxodecanoate
show the reaction diagram
-
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
show the reaction diagram
4-chlorobenzoyl-CoA + H2O
CoA + 4-chlorobenzoate
show the reaction diagram
-
-
-
?
4-Hydroxybenzoyl-CoA + H2O
4-Hydroxybenzoate + CoA
show the reaction diagram
4-hydroxybenzoyl-CoA + H2O
CoA + 4-hydroxybenzoate
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
CoA + 4-hydroxyphenylacetate
show the reaction diagram
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
show the reaction diagram
-
-
-
-
?
8-methyl-nonanoyl-CoA + H2O
8-methylnonanoate + CoA
show the reaction diagram
-
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
show the reaction diagram
acetyl-CoA + H2O
acetate + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
show the reaction diagram
acetyl-RifM1 + H2O
?
show the reaction diagram
-
-
-
?
acetyl-S-N-acetylcysteamine
N-acetylcysteamine + acetate
show the reaction diagram
acyl-CoA + H2O
CoA + a carboxylate
show the reaction diagram
arachidonoyl-CoA + H2O
CoA + arachidonate
show the reaction diagram
arachidoyl-CoA + H2O
CoA + arachidate
show the reaction diagram
benzoyl-CoA + H2O
CoA + benzoate
show the reaction diagram
-
-
-
-
?
beta-hydroxybutyryl-CoA + H2O
CoA + beta-hydroxybutyrate
show the reaction diagram
-
-
-
?
beta-methylcrotonyl-CoA + H2O
CoA + beta-methylcrotonate
show the reaction diagram
butanoyl-CoA + H2O
butanoate + CoA
show the reaction diagram
-
highest specific activity of the substrates tested
-
-
?
butyryl-CoA + H2O
butanoate + CoA
show the reaction diagram
butyryl-[acyl-carrier protein] + H2O
butanoate + acyl-carrier protein
show the reaction diagram
-
-
-
?
butyrylpanthetheine phosphate + H2O
panthetheine phosphate + butyrate
show the reaction diagram
-
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
show the reaction diagram
cholesteryl oleate + H2O
cholesterol + oleate
show the reaction diagram
-
-
-
-
?
choloyl-CoA + H2O
CoA + choloate
show the reaction diagram
cis-vaccenoyl-CoA + H2O
CoA + cis-vaccenic acid
show the reaction diagram
-
-
-
-
?
clofibroyl-CoA + H2O
CoA + clofibrate
show the reaction diagram
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
show the reaction diagram
decanoyl-CoA + H2O
CoA + decanoate
show the reaction diagram
decanoyl-CoA + H2O
decanoate + CoA
show the reaction diagram
-
-
-
-
?
dipalmitoylglycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
DL-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
show the reaction diagram
DL-3-hydroxybutyryl-CoA + H2O
?
show the reaction diagram
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-
-
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-
DL-3-hydroxybutyryl-CoA + H2O
CoA + ?
show the reaction diagram
-
-
-
?
DL-palmitoyl carnitine + H2O
palmitate + DL-carnitine
show the reaction diagram
-
-
-
-
?
docosahexanoyl-CoA + H2O
CoA + docosahexanoate
show the reaction diagram
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
show the reaction diagram
dodecanoyl-CoA + H2O
dodecanoate + CoA
show the reaction diagram
-
-
-
-
?
eicosanoyl-CoA + H2O
CoA + eicosanoate
show the reaction diagram
-
-
-
-
?
eicosanoyl-CoA + H2O
CoA + eicosanoic acid
show the reaction diagram
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
show the reaction diagram
-
-
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
show the reaction diagram
glutaryl-CoA + H2O
CoA + glutarate
show the reaction diagram
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
show the reaction diagram
hexanoyl-CoA + H2O
CoA + hexanoate
show the reaction diagram
isobutyryl-CoA + H2O
CoA + isobutyrate
show the reaction diagram
isovaleryl-CoA + H2O
CoA + isovalerate
show the reaction diagram
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
show the reaction diagram
lauroyl-CoA + H2O
CoA + lauric acid
show the reaction diagram
-
-
-
-
?
lauroyl-CoA + H2O
CoA + lauroate
show the reaction diagram
linolenoyl-CoA + H2O
CoA + linolenoate
show the reaction diagram
linoleoyl-CoA + H2O
CoA + linolate
show the reaction diagram
linoleoyl-CoA + H2O
CoA + linoleate
show the reaction diagram
malonyl-CoA + H2O
CoA + malonate
show the reaction diagram
malonyl-S-N-acetylcysteamine
N-acetylcysteamine + malonate
show the reaction diagram
methylmalonyl-CoA + H2O
CoA + methylmalonate
show the reaction diagram
methylmalonyl-RifM1 + H2O
?
show the reaction diagram
-
-
-
?
methylmalonyl-S-N-acetylcysteamine
N-acetylcysteamine + methylmalonate
show the reaction diagram
monolauroyl sucrose + H2O
lauroate + sucrose
show the reaction diagram
-
-
-
-
?
monoolein + H2O
oleate + glycerol
show the reaction diagram
-
-
-
-
?
monopalmitoyl sucrose + H2O
palmitate + sucrose
show the reaction diagram
-
-
-
-
?
myristoleoyl-CoA + H2O
CoA + myristoleic acid
show the reaction diagram
myristoyl-CoA + H2O
CoA + myristate
show the reaction diagram
myristoyl-CoA + H2O
CoA + myristic acid
show the reaction diagram
N-acetylcysteamine acetate
N-acetylcysteamine + acetate
show the reaction diagram
-
-
-
-
?
N-acetylcysteamine butyrate
N-acetylcysteamine + butyrate
show the reaction diagram
-
-
-
-
?
N-acetylcysteamine propionate
N-acetylcysteamine + propionate
show the reaction diagram
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
show the reaction diagram
n-butyryl-CoA + H2O
CoA + n-butyrate
show the reaction diagram
n-butyryl-pantetheine phosphate + H2O
?
show the reaction diagram
-
-
-
?
n-decanoyl-CoA + H2O
CoA + n-decanoate
show the reaction diagram
n-hexanoyl-CoA + H2O
CoA + n-hexanoate
show the reaction diagram
-
-
-
?
n-octanoyl-CoA + H2O
CoA + n-octanoate
show the reaction diagram
n-propionyl-CoA + H2O
CoA + n-propionate
show the reaction diagram
-
-
-
?
nafamostat + H2O
6-hydroxynaphthalene-2-carboximidamide + 4-carbamidamidobenzoic acid
show the reaction diagram
-
-
-
-
?
nonanoyl-CoA + H2O
nonanoate + CoA
show the reaction diagram
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
show the reaction diagram
octanoyl-CoA + H2O
CoA + octanoate
show the reaction diagram
octanoyl-CoA + H2O
octanoate + CoA
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
show the reaction diagram
oleoyl-CoA + H2O
oleate + CoA
show the reaction diagram
-
-
-
-
?
oleyl pantetheine + H2O
oleate + pantetheine
show the reaction diagram
-
-
-
-
?
oleyl-[acyl-carrier protein] + H2O
oleate + acyl-carrier protein
show the reaction diagram
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
show the reaction diagram
-
51% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl butyrate
p-nitrophenol + butyrate
show the reaction diagram
-
-
-
-
?
p-nitrophenyl dodecanoate + H2O
p-nitrophenol + dodecanoate
show the reaction diagram
-
8.7% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoate
show the reaction diagram
-
33% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl propanoate + H2O
p-nitrophenol + propanoate
show the reaction diagram
-
-
-
-
?
p-nitrophenyl propionate
p-nitrophenol + propionate
show the reaction diagram
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
show the reaction diagram
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleic acid
show the reaction diagram
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
show the reaction diagram
palmitoyl-CoA + H2O
CoA + palmitate
show the reaction diagram
palmitoyl-CoA + H2O
CoA + palmitic acid
show the reaction diagram
-
-
-
-
?
Palmitoyl-CoA + H2O
Palmitate + CoA
show the reaction diagram
-
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
show the reaction diagram
polyoxyethylene sorbitan monooleate + H2O
?
show the reaction diagram
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
show the reaction diagram
propionyl-RifM1 + H2O
?
show the reaction diagram
-
-
-
?
propionyl-S-N-acetylcysteamine
N-acetylcysteamine + propionate
show the reaction diagram
propionyl-s-N-acetylcysteamine + H2O
CoA + ?
show the reaction diagram
-
-
-
?
propionyl-[acyl-carrier protein] + H2O
propionate + acyl-carrier protein
show the reaction diagram
-
-
-
?
prostaglandin F2alpha-CoA + H2O
prostaglandin F2alpha + CoA
show the reaction diagram
-
-
-
?
salicylyl-CoA + H2O
CoA + salicylate
show the reaction diagram
-
-
-
-
?
salicylyl-EntB + H2O
EntB + salicylate
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
show the reaction diagram
stearoyl-CoA + H2O
CoA + stearic acid
show the reaction diagram
-
-
-
-
?
succinyl-CoA + H2O
CoA + succinate
show the reaction diagram
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
show the reaction diagram
tetradecylthioacetyl-CoA + H2O
CoA + tetradecylthioacetate
show the reaction diagram
-
best substrate
-
-
?
tetradecylthiopropionyl-CoA + H2O
CoA + tetradecylthiopropionate
show the reaction diagram
-
-
-
-
?
tiglyl-CoA + H2O
CoA + (2E)-2-methylbut-2-enoate
show the reaction diagram
-
-
-
?
tiglyl-CoA + H2O
CoA + (2E)-2-methylbut-2-enoic acid
show the reaction diagram
-
-
-
?
trihydroxycoprostanoyl-CoA + H2O
CoA + trihydroxycoprostanoate
show the reaction diagram
-
-
-
?
tripalmitoylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
show the reaction diagram
4-Hydroxybenzoyl-CoA + H2O
4-Hydroxybenzoate + CoA
show the reaction diagram
8-methyl-nonanoyl-CoA + H2O
8-methylnonanoate + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + H2O
acetate + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
show the reaction diagram
acyl-CoA + H2O
CoA + a carboxylate
show the reaction diagram
arachidonoyl-CoA + H2O
CoA + arachidonate
show the reaction diagram
butanoyl-CoA + H2O
butanoate + CoA
show the reaction diagram
-
highest specific activity of the substrates tested
-
-
?
decanoyl-CoA + H2O
decanoate + CoA
show the reaction diagram
-
-
-
-
?
dodecanoyl-CoA + H2O
dodecanoate + CoA
show the reaction diagram
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
show the reaction diagram
nonanoyl-CoA + H2O
nonanoate + CoA
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + H2O
octanoate + CoA
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + H2O
oleate + CoA
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
show the reaction diagram
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
show the reaction diagram
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
optimal range for ionic strength is 80-160 mM for both NaCl and KCl
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-acyl-sn-glycerol-3-phosphocholine
-
competitive inhibition at low concentration of palmitoyl-CoA
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
23% inhibition at 10 mM
13-hydroperoxyoctadecadienoic acid
-
only the mitochondrial enzyme form is inhibited, not the cytosolic one
2,2-dinitrofluorobenzene
-
2,4-dichlorophenoxyacetate
-
reduced activity in microsomes and mitochondria
3-dithiacarboxylic acid
-
palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats
-
3-O-methylmannose polysaccharide
-
-
-
4-chloromercuribenzoate
-
inhibitor of acyl-CoA thioesterase 2
4-hydroxyphenacyl-CoA
4-Pentenoate
-
reduced activity in microsomes
5,5'-dithiobis(2-nitrobenzoate)
-
-
6-O-methylglucose polysaccharide
-
-
-
Acetyl salicylate
-
reduced activity in microsomes
acetyl-CoA
acyl-CoA
albumin
-
-
-
AMP
-
acetyl-CoA as substrate
beta-hydroxybutyrate
-
moderately inhibits the microsomal enzyme activity
bezafibrate
-
-
bis-(4-nitrophenyl) phosphate
-
-
bovine serum albumin
-
cardiolipin
-
-
citrate
-
-
Clofibrate
Co2+
-
slightly inhibits the mitochondrial enzyme
CoA-S-S-CoA
-
competitive to acetyl-CoA; i.e. oxidized CoA, additive with NADH, kinetics
CoASH
D-carnitine
-
inhibits at concentrations over 6 mM
desulfoCoA
-
diethyl dicarbonate
-
1 mM, complete inhibition
diethyldicarbonate
diisopropylfluorophosphate
dimethyl (2-hydroxy-5-nitrobenzyl) sulfonium bromide
-
1 mM, 11% inhibition
dithiothreitol
-
1 mM, 20% inhibition
Dodecanoyl-CoA
-
substrate inhibition
DTNB
-
above 0.3 mM
EDTA
-
inhibits the activity of the mitochondrial enzyme at concentrations of 0.5 mM
FAD
-
slightly inhibits the microsomal enzyme
FMN
-
inhibits the mitochondrial-matrix enzyme activity
fumarate
-
inhibits the mitochondrial-matrix enzyme activity
gemfibrozil
-
-
GTP
-
acetyl-CoA as substrate
hexadecanoyl-CoA
-
substrate inhibition
hexyl-CoA
Ibuprofen
-
reduced activity in microsomes and mitochondria
iodoacetamide
L-carnitine
-
inhibits at concentrations over 6 mM
L-palmitoyl carnitine
lysophosphatidic acid
-
-
lysophosphatidylcholine
lysophosphatidylethanolamine
-
weakly inhibitory
lysophosphatidylinositol
lysophosphatidylserine
-
weakly inhibitory
malate
-
weak
methyl methanethiosulfonate
-
slight inhibition
methylene blue
-
photooxidation
N-bromosuccinimide
-
1 mM, complete inhibition
N-ethylmaleimide
NAD+
-
inhibits the mitochondrial-matrix enzyme
Nafamostat
-
competitive inhibition of palmitoyl-CoA hydrolytic activity
NGDA
-
isozymes CTE-I and MTE-I
Ni2+
-
-
nicotinic acid
-
inhibits the mitochondrial-matrix enzyme activity
nordihydroguaiaretic acid
-
inhibitor of acyl-CoA thioesterase 2
O,O-Diethyl-O-(2,4,5-trichlorophenyl)-phosphate
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-
O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
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-
O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothionate
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i.e. Chloropyrifos
O,O-Dimethyl-O-(2,4,5-trichloro-1-phenyl)-phosphate
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O,O-Dimethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
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i.e. Fospirate
octylglucoside
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50% inhibition at 0.3%
octylglycoside
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-
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oleic acid
p-chloromercuribenzoate
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1 mM, 12% inhibition
p-chloromercuribenzoic acid
p-hydroxymercuribenzoate
palmitic acid
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1 mM inhibits by 30%
palmitoyl-CoA
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0.1 mM, 67% inhibition of nafamostat
Pb2+
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slightly inhibits the mitochondrial enzyme
phenylacetylmethyl-CoA
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phenylmethylsulfonyl fluoride
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0.1 mM, 43% inhibition of nafamostat hydrolysis
picrylsulfonic acid
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1 mM, 11% inhibition
Sodium deoxycholate
tetradecanoyl-CoA
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substrate inhibition
Triton X-100
Triton X-35
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-
-
Triton X-405
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-
undecan-2-one-CoA
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unsaturated fatty acids
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-
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Valproate
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reduced activity in microsomes and mitochondria
additional information
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