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Literature summary for 3.1.2.20 extracted from
- Purification and characterization of long-chain acyl-CoA hydrolase from rat liver mitochondria (1979), Eur. J. Biochem., 96, 393-401.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | prevents inhibition together with serum albumin | Rattus norvegicus |  |
General Stability
| General Stability | Organism |
|---|---|
| bovine serum albumin stabilizes | Rattus norvegicus |
| glycerol and palmitoyl-CoA stabilize | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | - |
Rattus norvegicus | |
| sodium deoxycholate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0008 | - |
hexadecanoyl-CoA | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + H2O | Rattus norvegicus | - |
CoA + palmitate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 52.6fold | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C over 1 month | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + H2O | long-chain fatty-acyl-CoA | Rattus norvegicus | CoA + a carboxylate | - |
? | |
| decanoyl-CoA + H2O | - |
Rattus norvegicus | CoA + decanoate | - |
? | |
| dodecanoyl-CoA + H2O | i.e. lauroyl-CoA | Rattus norvegicus | CoA + dodecanoate | - |
? | |
| hexadecanoyl-CoA + H2O | i.e. palmitoyl-CoA | Rattus norvegicus | CoA + hexadecanoate | - |
? | |
| octadecanoyl-CoA + H2O | i.e. stearoyl-CoA | Rattus norvegicus | CoA + octadecanoate | - |
? | |
| oleoyl-CoA + H2O | - |
Rattus norvegicus | CoA + oleate | - |
? | |
| palmitoyl-CoA + H2O | - |
Rattus norvegicus | CoA + palmitate | - |
? | |
| tetradecanoyl-CoA + H2O | i.e. myristoyl-CoA | Rattus norvegicus | CoA + tetradecanoate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.5 | - |
Rattus norvegicus |
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