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Literature summary for 3.1.2.20 extracted from

  • Han, S.; Cohen, D.E.
    Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation (2012), J. Lipid Res., 53, 2620-2631.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed as a GST-fusion protein in Escherichia coli Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information thioesterase domain alone of Them1 is sufficient to yield active recombinant protein, START domain is required for optimal enzyme activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Mus musculus
CoASH
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0075
-
palmitoyl-CoA pH 7.5, 37°C Mus musculus
0.0079
-
lauroyl-CoA pH 7.5, 37°C Mus musculus
0.0081
-
myristoyl-CoA pH 7.5, 37°C Mus musculus
0.0093
-
linoleoyl-CoA pH 7.5, 37°C Mus musculus
0.0128
-
oleoyl-CoA pH 7.5, 37°C Mus musculus
0.0133
-
Arachidonoyl-CoA pH 7.5, 37°C Mus musculus
0.0136
-
palmitoleoyl-CoA pH 7.5, 37°C Mus musculus
0.0232
-
malonyl-CoA pH 7.5, 37°C Mus musculus
0.0279
-
stearoyl-CoA pH 7.5, 37°C Mus musculus
0.0479
-
DL-3-hydroxybutyryl-CoA pH 7.5, 37°C Mus musculus
0.0481
-
acetyl-CoA pH 7.5, 37°C Mus musculus
0.0498
-
phenylacetyl-CoA pH 7.5, 37°C Mus musculus
0.0682
-
2-butenoyl-CoA pH 7.5, 37°C Mus musculus
0.0868
-
DL-3-hydroxy-3-methylglutaryl-CoA pH 7.5, 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm concentrated to the greatest extent in liver Mus musculus 5737
-
microsome concentrated to the greatest extent in brown adipose tissue Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
112000
-
FPLC Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-butenoyl-CoA + H2O
-
Mus musculus CoA + 2-butenoate
-
?
acetyl-CoA + H2O
-
Mus musculus CoA + acetate
-
?
arachidonoyl-CoA + H2O
-
Mus musculus CoA + arachidonate
-
?
DL-3-hydroxy-3-methylglutaryl-CoA + H2O
-
Mus musculus CoA + 3-hydroxy-3-methylglutarate
-
?
DL-3-hydroxybutyryl-CoA + H2O
-
Mus musculus ?
-
?
lauroyl-CoA + H2O
-
Mus musculus CoA + lauroate
-
?
linoleoyl-CoA + H2O
-
Mus musculus CoA + linoleate
-
?
malonyl-CoA + H2O
-
Mus musculus CoA + malonate
-
?
myristoyl-CoA + H2O
-
Mus musculus CoA + myristate
-
?
oleoyl-CoA + H2O
-
Mus musculus CoA + oleate
-
?
palmitoleoyl-CoA + H2O
-
Mus musculus CoA + palmitoleoate
-
?
palmitoyl-CoA + H2O
-
Mus musculus CoA + palmitate
-
?
phenylacetyl-CoA + H2O
-
Mus musculus CoA + phenylacetate
-
?
stearoyl-CoA + H2O
-
Mus musculus CoA + stearate
-
?

Subunits

Subunits Comment Organism
dimer
-
Mus musculus

Synonyms

Synonyms Comment Organism
acyl-CoA thioesterase 11
-
Mus musculus
StarD14
-
Mus musculus
Them1
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2
-
Arachidonoyl-CoA pH 7.5, 37°C Mus musculus
2.3
-
stearoyl-CoA pH 7.5, 37°C Mus musculus
2.7
-
linoleoyl-CoA pH 7.5, 37°C Mus musculus
3.2
-
oleoyl-CoA pH 7.5, 37°C Mus musculus
3.2
-
phenylacetyl-CoA pH 7.5, 37°C Mus musculus
4.7
-
myristoyl-CoA pH 7.5, 37°C Mus musculus
4.7
-
palmitoleoyl-CoA pH 7.5, 37°C Mus musculus
5.3
-
lauroyl-CoA pH 7.5, 37°C Mus musculus
8.5
-
palmitoyl-CoA pH 7.5, 37°C Mus musculus
9.6
-
malonyl-CoA pH 7.5, 37°C Mus musculus
11
-
2-butenoyl-CoA pH 7.5, 37°C Mus musculus
12
-
DL-3-hydroxy-3-methylglutaryl-CoA pH 7.5, 37°C Mus musculus
13
-
DL-3-hydroxybutyryl-CoA pH 7.5, 37°C Mus musculus
24
-
acetyl-CoA pH 7.5, 37°C Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus