Reference on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tamaki, N.; Aoyama, H.; Kubo, K.; Ikeda, T.; Hama, T.
Purification and properties of beta-alanine aminotransferase from rabbit liver
J. Biochem.
92
1009-1017
1982
Oryctolagus cuniculus
Tamaki, N.; Fujimoto, S.; Mizota, C.; Kikugawa, M.
Identity of beta-alanine-oxo-glutarate aminotransferase and L-beta-aminoisobutyrate aminotransferase in rat liver
Biochim. Biophys. Acta
925
238-240
1987
Rattus norvegicus
Schousboe, A.; Wu, J.Y.; Roberts, E.
Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain
Biochemistry
12
2868-2873
1973
Mus musculus
Choi, S.Y.; Kim, D.S.
Catalytic and structural properties of 4-aminobutyrate aminotransferase
Han'guk Saenghwa Hak Hoe Chi
24
508-514
1991
Sus scrofa
-
Tunnicliff, G.; Youngs, T.L.
Competitive inhibition of mouse brain gamma-aminobutyrate aminotransferase by ATP
Proc. Soc. Exp. Biol. Med.
192
11-15
1989
Mus musculus
Schousboe, A.; Wu, J.Y.; Roberts, E.
Subunit structure and kinetic properties of 4-aminobutyrate-2-ketoglutarate transaminase purified from mouse brain
J. Neurochem.
23
1189-1195
1974
Mus musculus
Bloch-Tardy, M.; Rolland, B.; Gonnard, P.
Pig brain 4-aminobutyrate 2-ketoglutarate transaminase. Purification, kinetics and physical properties
Biochimie
56
823-832
1974
Sus scrofa
Buu, N.T.; van Gelder, N.M.
Differences in biochemical properties of gamma-aminobutyric acid aminotransferase from synaptosome-enriched and cytoplasmic mitochondria-enriched subcellular fractions of mouse brain
Can. J. Physiol. Pharmacol.
52
674-680
1974
Mus musculus
Cooper, A.J.L.
Glutamate-gamma-aminobutyrate transaminase
Methods Enzymol.
113
80-82
1985
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Buzenet, A.M.; Fages, C.; Bloch-Tardy, M.; Gonnard, P.
Purification and properties of 4-aminobutyrate 2-ketoglutarate aminotransferase from pig liver
Biochim. Biophys. Acta
522
400-411
1978
Sus scrofa
Matre, M.; Ciesielski, L.; Cash, C.; Mandel, P.
Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors
Biochim. Biophys. Acta
522
385-399
1978
Homo sapiens, Rattus norvegicus
Tunnicliff, G.; Ngo, T.T.; Rojo-Ortega, J.M.; Barbeau, A.
The inhibition by substrate analogues of gamma-aminobutyrate aminotransferase from mitochondria of different subcellular fractions of rat brain
Can. J. Biochem.
55
479-484
1977
Rattus norvegicus
Cash, C.; Matre, M.; Ciesielski, L.; Mandel, P.
Purification and partial characterisation of 4-aminobutyrate 2-ketoglutarate transaminase from human brain
FEBS Lett.
47
199-203
1974
Homo sapiens
Tamaki, N.; Kubo, K.; Aoyama, H.; Funatsuka, A.
Inhibitory effect of 6-azauracil on purified rabbit liver 4-aminobutyrate aminotransferase
J. Biochem.
93
955-959
1983
Oryctolagus cuniculus
Matre, M.; Ciesielski, L.; Cash, C.; Mandel, P.
Purification and studies on some properties of the 4-aminobutyrate: 2-oxoglutarate transaminase from rat brain
Eur. J. Biochem.
52
157-169
1975
Rattus norvegicus
Jeffery, D.; Rutherford, D.M.; Witzman, P.D.J.; Lunt, G.G.
Purification and partial characterization of 4-aminobutyrate:2-oxoglutarate aminotransferase from sheep brain and locust ganglia
Biochem. J.
249
795-799
1988
Schistocerca gregaria, Ovis aries
Markovic-Housley, Z.; Schirmer, T.; Fol, B.; Jansonius, J.N.; De Biase, D.; John, R.A.
Crystallization and preliminary X-ray analysis of gamma-aminobutyric acid transaminase
J. Mol. Biol.
214
821-823
1990
Sus scrofa
Kwon, O.S.; Park, J.; Churchich, J.E.
Brain 4-aminobutyrate aminotransferase. Isolation and sequence of a cDNA encoding the enzyme
J. Biol. Chem.
267
7215-7216
1992
Sus scrofa
Kaneko, M.; Fujimoto, S.; Kikugawa, M.; Tamaki, N.
Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine
FEBS Lett.
276
115-118
1990
Rattus norvegicus
Lippert, B.; Metcalf, B.W.; Jung, M.J.; Casara, P.
4-Amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain
Eur. J. Biochem.
74
441-445
1977
Pseudomonas fluorescens, Rattus norvegicus
Rando, R.R.; Bangerter, F.W.
The irreversible inhibition of mouse brain gamma-aminobutyric acid (GABA)-alpha-ketoglutaric acid transaminase by gabaculine
J. Am. Chem. Soc.
98
6762-6764
1976
Mus musculus
Fowler, L.J.; John, R.A.
Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo
Biochem. J.
130
569-573
1972
Rattus norvegicus
Der Garabedian, P.A.; Lotti, A.M.; Vermeersch, J.J.
4-Aminobutyrate:2-oxoglutarate aminotransferase from Candida. Purification and properties
Eur. J. Biochem.
156
589-596
1986
Candida guilliermondii var. membranaefaciens, Candida guilliermondii var. membranaefaciens Y43
Aurich, H.
Uber die beta-Alanin-alpha-Ketoglutarat-Transaminase aus Neurospora crassa
Hoppe-Seyler's Z. Physiol. Chem.
326
25-33
1961
Neurospora crassa
-
Scott, E.M.; Jacoby, W.B.
Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens
J. Biol. Chem.
234
932-936
1959
Pseudomonas fluorescens
Yonaha, K.; Toyama, S.
gamma-Aminobutyrate:alpha-ketoglutarate aminotransferase from Pseudomonas sp. F-126: purification, crystallization, and enzymologic properties
Arch. Biochem. Biophys.
200
156-164
1980
Pseudomonas sp., Pseudomonas sp. F-126
Jung, M.J.; Metcalf, B.W.
Catalytic inhibition of gamma-aminobutyric acid - alpha-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog
Biochem. Biophys. Res. Commun.
67
301-306
1975
Pseudomonas fluorescens
Park, J.; Osei, Y.D.; Churchich, J.E.
Isolation and characterization of recombinant mitochondrial 4-aminobutyrate aminotransferase
J. Biol. Chem.
268
7636-7639
1993
Sus scrofa
Yonaha, K.; Suzuki, K.; Toyama, S.
4-Aminobutyrate:2-oxoglutarate aminotransferase of Streptomyces griseus: purification and properties
Eur. J. Biochem.
146
101-106
1985
Streptomyces griseus
Tokunaga, M.; Nakano, Y.; Kitaoka, S.
Subcellualr localization of the GABA-shunt enzymes in Euglena gracilis strain Z
J. Protozool.
26
471-473
1979
Euglena gracilis, Euglena gracilis mutant
Kaneko, M.; Kontani, Y.; Kikugawa, M.; Tamaki, N.
Inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by 5-fluorouracil and alpha-fluoro-beta-alanine
Biochim. Biophys. Acta
1122
45-49
1992
Rattus norvegicus
Cavallotti, D.; Artico, M.; De Santis, S.; Cavallotti, C.
Occurrence of gamma-aminobutyric acid-transaminase activity in nerve fibers of human thymus
Hum. Immunol.
60
1072-1079
1999
Homo sapiens
Tunnicliff, G.; Crites, G.J.
Chemical inactivation of bacterial GABA aminotransferase
Biochem. Mol. Biol. Int.
46
43-54
1998
Pseudomonas fluorescens
Wu, Y.; Wang, W.; Richerson, G.B.
GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter
J. Neurosci.
21
2630-2639
2001
Rattus norvegicus
Sung, B.K.; Kim, Y.T.
Structural arrangement for functional requirements of brain recombinant 4-aminobutyrate aminotransferase
J. Biochem. Mol. Biol.
33
43-48
2000
Sus scrofa
-
Cavalotti, C.; Artico, M.; De Santis, S.
Occurence of GABA transaminase in the thymus gland of juvenile and aged rats
Eur. J. Histochem.
43
293-299
1999
Rattus norvegicus
Fu, M.; Nikolic, D.; Van Breemen, R.B.; Silverman, R.B.
Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid
J. Am. Chem. Soc.
121
7751-7759
1999
Sus scrofa
-
Choi, S.; Storici, P.; Schirmer, T.; Silverman, R.B.
Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase
J. Am. Chem. Soc.
124
1620-1624
2002
Sus scrofa
Jeon, S.G.; Bahn, J.H.; Jang, J.S.; Park, J.; Kwon, O.S.; Cho, S.W.; Choi, S.Y.
Human brain GABA transaminase tissue distribution and molecular expression
Eur. J. Biochem.
267
5601-5607
2000
Homo sapiens
Storici, P.; Capitani, G.; De Biase, D.; Moser, M.; John, R.A.; Jansonius, J.N.; Schirmer, T.
Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy
Biochemistry
38
8628-8634
1999
Sus scrofa
Kontani, Y.; Sakata, S.F.; Matsuda, K.; Ohyama, T.; Sano, K.; Tamaki, N.
The mature size of rat 4-aminobutyrate aminotransferase is different in liver and brain
Eur. J. Biochem.
264
218-222
1999
Rattus norvegicus
Qiu, J.; Pingsterhaus, J.M.; Silverman, R.B.
Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase
J. Med. Chem.
42
4725-4728
1999
Sus scrofa
Kontani, Y.; Kawasaki, S.; Kaneko, M.; Matsuda, K.; Sakata, S.F.; Tamaki, N.
Inhibitory effect of ethanol administration on beta-alanine-2-oxoglutarate aminotransferase (GABA aminotransferase) in disulfiram-pretreated rats
J. Nutr. Sci. Vitaminol.
44
165-176
1998
Rattus norvegicus
Koo, Y.K.; Nandi, D.; Silverman, R.B.
The multiple active enzyme species of gamma-aminobutyric acid aminotransferase are not isozymes
Arch. Biochem. Biophys.
374
248-254
2000
Sus scrofa
Kim, Y.T.; Song, Y.H.; Churchich, J.E.
Recombinant brain 4-aminobutyrate aminotransferases overexpression, purification, and identification of Lys-330 at the active site
Biochim. Biophys. Acta
1337
248-256
1997
Sus scrofa
Prell, J.; Boesten, B.; Poole, P.; Priefer, U.B.
The Rhizobium leguminosarum bv. viciae VF39 gamma-aminobutyrate (GABA) aminotransferase gene (gabT) is induced by GABA and highly expressed in bacteroids
Microbiology
148
615-623
2002
Rhizobium leguminosarum bv. viciae (Q9AGD3), Rhizobium leguminosarum bv. viciae VF39 (Q9AGD3), Rhizobium leguminosarum bv. viciae VF39
Schor, D.S.; Struys, E.A.; Hogema, B.M.; Gibson, K.M.; Jakobs, C.
Development of a stable-isotope dilution assay for gamma-aminobutyric acid (GABA) transaminase in isolated leukocytes and evidence that GABA and beta-alanine transaminases are identical
Clin. Chem.
47
525-531
2001
Homo sapiens
Van Cauwenberghe, O.R.; Shelp, B.J.
Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum
Phytochemistry
52
575-581
1999
Nicotiana tabacum
-
Kang, T.C.; Park, S.K.; Bahn, J.H.; Chang, J.S.; Cho, S.W.; Choi, S.Y.; Won, M.H.
Comparative studies on the GABA-transaminase immunoreactivity in rat and gerbil brains
Mol. Cells
11
321-325
2001
Meriones unguiculatus, Rattus norvegicus
Sung, B.K.; Cho, J.J.; Kim, Y.T.
Functional expression and characterization of C-terminal mutant of 4-aminobutyrate aminotransferase
J. Biochem. Mol. Biol.
32
181-188
1999
Sus scrofa
-
Jeon, S.G.; Bahn, J.H.; Jang, J.S.; Jang, S.H.; Lee, B.R.; Lee, K.S.; Park, J.; Kang, T.C.; Won, M.H.; Kim, H.B.; Kwo, O.S.; Cho, S.W.; Choi, S.Y.
Molecular cloning and functional expression of bovine brain GABA transaminase
Mol. Cells
12
91-96
2001
Bos taurus
Liu, W.; Peterson, P.E.; Carter, R.J.; Zhou, X.; Langston, J.A.; Fisher, A.J.; Toney, M.D.
Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase
Biochemistry
43
10896-10905
2004
Escherichia coli (P22256), Escherichia coli
Storici, P.; Qiu, J.; Schirmer, T.; Silverman, R.B.
Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography
Biochemistry
43
14057-14063
2004
Sus scrofa
Liu, W.; Peterson, P.E.; Langston, J.A.; Jin, X.; Zhou, X.; Fisher, A.J.; Toney, M.D.
Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase
Biochemistry
44
2982-2992
2005
Escherichia coli (P22256), Escherichia coli
Yuan, H.; Silverman, R.B.
New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: Design, synthesis, and biological activity
Bioorg. Med. Chem.
14
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2005
Sus scrofa
Voellmy, R.; Leisinger, T.
Role of 4-aminobutyrate aminotransferase in the arginine metabolism of Pseudomonas aeruginosa
J. Bacteriol.
128
722-729
1976
Pseudomonas aeruginosa
Storici, P.; De Biase, D.; Bossa, F.; Bruno, S.; Mozzarelli, A.; Peneff, C.; Silverman, R.B.; Schirmer, T.
Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin
J. Biol. Chem.
279
363-373
2004
Sus scrofa (P80147), Sus scrofa
Sulaiman, S.A.J.; Suliman, F.E.O.; Barghouthi, S.
Kinetic studies of the inhibition of GABA-T by gamma-vinyl GABA and taurine
J. Enzyme Inhib. Med. Chem.
18
297-301
2003
Pseudomonas fluorescens
Yoon, C.S.; Kim, D.W.; Jang, S.H.; Lee, B.R.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; An, J.J.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Eum, W.S.; Choi, S.Y.
Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking
Mol. Cells
18
214-219
2004
Homo sapiens
Kim, D.W.; Yoon, C.S.; Eum, W.S.; Lee, B.R.; An, J.J.; Lee, S.H.; Lee, S.R.; Ahn, J.Y.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Choi, S.Y.
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site
Mol. Cells
18
314-319
2004
Homo sapiens
Ansari, M.I.; Lee, R.H.; Chen, S.C.G.
A novel senescence-associated gene encoding gamma-aminobutyric acid (GABA):pyruvate transaminase is upregulated during rice leaf senescence
Physiol. Plant.
123
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2005
Oryza sativa (Q7XN11)
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Choi, S.Y.; Ahn, E.M.; Song, M.C.; Kim, D.W.; Kang, J.H.; Kwon, O.S.; Kang, T.C.; Baek, N.I.
In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica
Phytother. Res.
19
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2005
Bos taurus
Yogeeswari, P.; Sriram, D.; Thirumurugan, R.; Jeewanlal, L.R.; Jit, S.; Ragavendran, J.V.; Kavya, R.; Rakhra, K.; Saraswat, V.
Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors
Acta Pharm.
56
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2006
Pseudomonas fluorescens
Ricci, L.; Frosini, M.; Gaggelli, N.; Valensin, G.; Machetti, F.; Sgaragli, G.; Valoti, M.
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis
Biochem. Pharmacol.
71
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2006
Oryctolagus cuniculus
Wang, Z.; Silverman, R.B.
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase
Bioorg. Med. Chem.
14
2242-2252
2006
Sus scrofa
Tao, Y.H.; Xu, H.B.; Yang, X.L.
Inactivation of GABA transaminase by 4-acryloylphenol
Bioorg. Med. Chem. Lett.
16
3719-3722
2006
Rattus norvegicus
Tao, Y.H.; Yuan, Z.; Tang, X.Q.; Xu, H.B.; Yang, X.L.
Inhibition of GABA shunt enzymes activity by 4-hydroxybenzaldehyde derivatives
Bioorg. Med. Chem. Lett.
16
592-595
2006
Homo sapiens
Yuan, H.; Silverman, R.B.
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase
Bioorg. Med. Chem. Lett.
17
1651-1654
2007
Homo sapiens
Martyniuk, C.J.; Awad, R.; Hurley, R.; Finger, T.E.; Trudeau, V.L.
Glutamic acid decarboxylase 65, 67, and GABA-transaminase mRNA expression and total enzyme activity in the goldfish (Carassius auratus) brain
Brain Res.
1147
154-166
2007
Carassius auratus, Carassius auratus (Q2PZI2)
Choi, J.H.; Lee, D.U.
A new citryl glycoside from Gastrodia elata and its inhibitory activity on GABA transaminase
Chem. Pharm. Bull.
54
1720-1721
2006
Rattus norvegicus
Andersen, G.; Andersen, B.; Dobritzsch, D.; Schnackerz, K.D.; Piskur, J.
A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast
FEBS J.
274
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2007
Lachancea kluyveri, Lachancea kluyveri (A5H0J5), Lachancea kluyveri (A5H0J6), Schizosaccharomyces pombe (O13837), Schizosaccharomyces pombe, Saccharomyces cerevisiae (P17649), Saccharomyces cerevisiae
Lu, H.; Silverman, R.B.
Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors
J. Med. Chem.
49
7404-7412
2006
Sus scrofa
Patel, A.B.; de Graaf, R.A.; Martin, D.L.; Battaglioli, G.; Behar, K.L.
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo
J. Neurochem.
97
385-396
2006
Rattus norvegicus
Martyniuk, C.J.; Chang, J.P.; Trudeau, V.L.
The effects of GABA agonists on glutamic acid decarboxylase, GABA-transaminase, activin, salmon gonadotrophin-releasing hormone and tyrosine hydroxylase mRNA in the goldfish (Carassius auratus) neuroendocrine brain
J. Neuroendocrinol.
19
390-396
2007
Carassius auratus
Wu, C.; Zhou, S.; Zhang, Q.; Zhao, W.; Peng, Y.
Molecular cloning and differential expression of an gamma-aminobutyrate transaminase gene, OsGABA-T, in rice (Oryza sativa) leaves infected with blast fungus
J. Plant Res.
119
663-669
2006
Oryza sativa
Sonnewald, U.; Kortner, T.M.; Qu, H.; Olstad, E.; Sunol, C.; Bak, L.K.; Schousboe, A.; Waagepetersen, H.S.
Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools
Neurochem. Int.
48
572-578
2006
Mus musculus
Henjum, S.; Hassel, B.
High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study
Neurochem. Int.
50
365-370
2007
Sus scrofa
Clift, M.D.; Ji, H.; Deniau, G.P.; OHagan, D.; Silverman, R.B.
Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding
Biochemistry
46
13819-13828
2007
Sus scrofa (P80147)
Clift, M.D.; Silverman, R.B.
Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase
Bioorg. Med. Chem. Lett.
18
3122-3125
2008
Sus scrofa (P80147)
Wang, Q.P.; Jammoul, F.; Duboc, A.; Gong, J.; Simonutti, M.; Dubus, E.; Craft, C.M.; Ye, W.; Sahel, J.A.; Picaud, S.
Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina
Eur. J. Neurosci.
27
2177-2187
2008
Mus musculus
Brozoski, T.J.; Spires, T.J.; Bauer, C.A.
Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model
J. Assoc. Res. Otolaryngol.
8
105-118
2007
Rattus norvegicus
Mayer, J.; Cook, A.M.
Homotaurine metabolized to 3-sulfopropanoate in Cupriavidus necator H16: enzymes and genes in a patchwork pathway
J. Bacteriol.
191
6052-6058
2009
Cupriavidus necator (Q0K2K2), Cupriavidus necator
Ludewig, F.; Hueser, A.; Fromm, H.; Beauclair, L.; Bouche, N.
Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis
PLoS ONE
3
e3383
2008
Arabidopsis thaliana
Tao, Y.H.; Xu, H.B.; Yang, X.L.
Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one
Bioorg. Med. Chem. Lett.
19
731-734
2009
Homo sapiens
Renault, H.; Roussel, V.; El Amrani, A.; Arzel, M.; Renault, D.; Bouchereau, A.; Deleu, C.
The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance
BMC Plant Biol.
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20
2010
Arabidopsis thaliana
Suzuki, Y.; Takahashi, H.; Fukuda, M.; Hino, H.; Kobayashi, K.; Tanaka, J.; Ishii, E.
Beta-hydroxybutyrate alters GABA-transaminase activity in cultured astrocytes
Brain Res.
1268
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2009
Rattus norvegicus (P50554)
Clark, S.M.; Di Leo, R.; Dhanoa, P.K.; Van Cauwenberghe, O.R.; Mullen, R.T.; Shelp, B.J.
Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate
J. Exp. Bot.
60
1743-1757
2009
Arabidopsis thaliana (Q94CE5), Arabidopsis thaliana
Clark, S.M.; Di Leo, R.; Van Cauwenberghe, O.R.; Mullen, R.T.; Shelp, B.J.
Subcellular localization and expression of multiple tomato gamma-aminobutyrate transaminases that utilize both pyruvate and glyoxylate
J. Exp. Bot.
60
3255-3267
2009
Solanum lycopersicum (Q84P52), Solanum lycopersicum (Q84P53), Solanum lycopersicum (Q84P54), Solanum lycopersicum
Tsuji, M.; Aida, N.; Obata, T.; Tomiyasu, M.; Furuya, N.; Kurosawa, K.; Errami, A.; Gibson, K.M.; Salomons, G.S.; Jakobs, C.; Osaka, H.
A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy
J. Inherit. Metab. Dis.
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2010
Homo sapiens
Jones, S.M.; Palmer, M.J.
Activation of the tonic GABAC receptor current in retinal bipolar cell terminals by nonvesicular GABA release
J. Neurophysiol.
102
691-699
2009
Carassius auratus
Yang, J.; Johnson, C.; Shen, J.
Detection of reduced GABA synthesis following inhibition of GABA transaminase using in vivo magnetic resonance signal of [13C]GABA C1
J. Neurosci. Methods
182
236-243
2009
Rattus norvegicus
Awad, R.; Muhammad, A.; Durst, T.; Trudeau, V.L.; Arnason, J.T.
Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity
Phytother. Res.
23
1075-1081
2009
Rattus norvegicus
Hawker, D.D.; Silverman, R.B.
Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase
Bioorg. Med. Chem.
20
5763-5773
2012
Sus scrofa
Juncosa, J.I.; Groves, A.P.; Xia, G.; Silverman, R.B.
Probing the steric requirements of the gamma-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin
Bioorg. Med. Chem.
21
903-911
2013
Sus scrofa
Simpson, J.; Clark, S.; Portt, A.; Allan, W.; Makhmoudova, A.; Rochon, A.; Shelp, B.
gamma-aminobutyrate transaminase limits the catabolism of gamma-aminobutyrate in cold-stressed arabidopsis plants: Insights from an overexpression mutant
Botany
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522-527
2010
Arabidopsis thaliana
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Trobacher, C.; Clark, S.; Bozzo, G.; Mullen, R.; DeEll, J.; Shelp, B.
Catabolism of GABA in apple fruit: Subcellular localization and biochemical characterization of two gamma-aminobutyrate transaminases
Postharvest Biol. Technol.
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2013
Malus domestica (J9XGP8), Malus domestica (J9XGZ5)
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Besse, A.; Wu, P.; Bruni, F.; Donti, T.; Graham, B.H.; Craigen, W.J.; McFarland, R.; Moretti, P.; Lalani, S.; Scott, K.L.; Taylor, R.W.; Bonnen, P.E.
The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism
Cell Metab.
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417-427
2015
Homo sapiens (P80404)
Mathew, B.; Ahsan, M.
Molecular recognisation of 3a, 4-dihydro-3-H-indeno [1, 2-C] pyrazole-2-carboxamide/carbothioamide anticonvulsant analogues towards GABA-aminotransferase - an in silico approach
Cent. Nerv. Syst. Agents Med. Chem.
14
39-42
2014
Sus scrofa (P80147)
Han, Y.; Cao, D.; Li, X.; Zhang, R.; Yu, F.; Ren, Y.; An, L.
Attenuation of gamma-aminobutyric acid (GABA) transaminase activity contributes to GABA increase in the cerebral cortex of mice exposed to beta-cypermethrin
Hum. Exp. Toxicol.
33
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2014
Mus musculus (P61922)
Lee, H.; Doud, E.H.; Wu, R.; Sanishvili, R.; Juncosa, J.I.; Liu, D.; Kelleher, N.L.; Silverman, R.B.
Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115)
J. Am. Chem. Soc.
137
2628-2640
2015
Sus scrofa (P80147)
So, J.; Lim, Y.; Kim, S.; Kim, H.; Rhee, I.
Co-expression of gamma-aminobutyrate aminotransferase and succinic semialdehyde dehydrogenase genes for the enzymatic analysis of gamma-aminobutyric acid in Escherichia coli
J. Appl. Biol. Chem.
56
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2013
Pseudomonas fluorescens, Pseudomonas fluorescens KCCM 12537
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Maguire, S.E.; Rhoades, S.; Chen, W.F.; Sengupta, A.; Yue, Z.; Lim, J.C.; Mitchell, C.H.; Weljie, A.M.; Sehgal, A.
Independent effects of gamma-aminobutyric acid transaminase (GABAT) on metabolic and sleep homeostasis
J. Biol. Chem.
290
20407-20416
2015
Drosophila melanogaster
Patel, J.; Dholakiya, B.; Mishra, N.
In vitro brain GABA-transaminase activity of 1-(4-acetylphenyl)-3-aryloxypyrrolidine-2,5-dione derivatives
J. Pharm. Res.
6
442-446
2013
Mus musculus (P61922)
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Cao, J.; Barbosa, J.M.; Singh, N.; Locy, R.D.
GABA transaminases from Saccharomyces cerevisiae and Arabidopsis thaliana complement function in cytosol and mitochondria
Yeast
30
279-289
2013
Arabidopsis thaliana (Q94CE5), Arabidopsis thaliana
Kim, H.T.; Khang, T.U.; Baritugo, K.A.; Hyun, S.M.; Kang, K.H.; Jung, S.H.; Song, B.K.; Park, K.; Oh, M.K.; Kim, G.B.; Kim, H.U.; Lee, S.Y.; Park, S.J.; Joo, J.C.
Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical
Metab. Eng.
51
99-109
2019
Corynebacterium glutamicum (A0A0U4XQS6)
Iftikhar, H.; Batool, S.; Deep, A.; Narasimhan, B.; Sharma, P.; Malhotra, M.
In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase
Arab. J. Chem.
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S1267-S1275
2017
Sus scrofa (P80147), Homo sapiens (P80404)
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Hong, J.; Kim, K.J.
Crystal structure of gamma-aminobutyrate aminotransferase in complex with a PLP-GABA adduct from Corynebacterium glutamicum
Biochem. Biophys. Res. Commun.
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601-606
2019
Corynebacterium glutamicum (Q8NT35), Corynebacterium glutamicum, Corynebacterium glutamicum LMG 3730 (Q8NT35), Corynebacterium glutamicum BCRC 11384 (Q8NT35), Corynebacterium glutamicum ATCC 13032 (Q8NT35), Corynebacterium glutamicum JCM 1318 (Q8NT35), Corynebacterium glutamicum NCIMB 10025 (Q8NT35), Corynebacterium glutamicum DSM 20300 (Q8NT35)
Richter, A.A.; Mais, C.N.; Czech, L.; Geyer, K.; Hoeppner, A.; Smits, S.H.J.; Erb, T.J.; Bange, G.; Bremer, E.
Biosynthesis of the stress-protectant and chemical chaperon ectoine biochemistry of the transaminase EctB
Front. Microbiol.
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2811
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Paenibacillus lautus (D3EKC0), Paenibacillus lautus Y412MC10 (D3EKC0)
Zhang, S.; Qian, X.; Chang, S.; Dismukes, G.C.; Bryant, D.A.
Natural and synthetic variants of the tricarboxylic acid cycle in cyanobacteria introduction of the GABA shunt into Synechococcus sp. PCC 7002
Front. Microbiol.
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1972
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Synechococcus sp. PCC 7002 (B1XNF8), Synechococcus sp. PCC 6803 (P73133)
Juncosa, J.I.; Takaya, K.; Le, H.V.; Moschitto, M.J.; Weerawarna, P.M.; Mascarenhas, R.; Liu, D.; Dewey, S.L.; Silverman, R.B.
Design and mechanism of (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, a highly potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of addiction
J. Am. Chem. Soc.
140
2151-2164
2018
Rattus norvegicus (P50554), Sus scrofa (P80147)
Wang, J.X.; Mu, J.D.; Ma, L.X.; Sun, T.Y.; Qian, X.; Yu, W.Y.; Tian, Y.; Song, Y.; Gan, Y.Y.; Guo, M.W.; Ren, X.X.; Li, J.L.
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating gamma-aminobutyric acid transaminase and enhancing gamma-aminobutyric acid
NeuroReport
31
708-716
2020
Rattus norvegicus (P50554), Rattus norvegicus Sprague-Dawley (P50554)
Chen, Y.; Zhao, G.; Li, N.; Luo, Z.; Wang, X.; Gu, J.
Role of 4-aminobutyrate aminotransferase (ABAT) and the lncRNA co-expression network in the development of myelodysplastic syndrome
Oncol. Rep.
42
509-520
2019
Homo sapiens (P80404)
Moschitto, M.J.; Silverman, R.B.
Synthesis of (S)-3-amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic acid (OV329), a potent inactivator of gamma-aminobutyric acid aminotransferase
Org. Lett.
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4589-4592
2018
Homo sapiens (P80404)
Shi, F.; Si, H.; Ni, Y.; Zhang, L.; Li, Y.
Transaminase encoded by NCgl2515 gene of Corynebacterium glutamicum ATCC13032 is involved in gamma-aminobutyric acid decomposition
Process Biochem.
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55-60
2017
Corynebacterium glutamicum (P46395), Corynebacterium glutamicum (Q8NT48), Corynebacterium glutamicum LMG 3730 (P46395), Corynebacterium glutamicum LMG 3730 (Q8NT48), Corynebacterium glutamicum BCRC 11384 (P46395), Corynebacterium glutamicum BCRC 11384 (Q8NT48), Corynebacterium glutamicum ATCC 13032 (P46395), Corynebacterium glutamicum ATCC 13032 (Q8NT48), Corynebacterium glutamicum JCM 1318 (P46395), Corynebacterium glutamicum JCM 1318 (Q8NT48), Corynebacterium glutamicum NCIMB 10025 (P46395), Corynebacterium glutamicum NCIMB 10025 (Q8NT48), Corynebacterium glutamicum DSM 20300 (P46395), Corynebacterium glutamicum DSM 20300 (Q8NT48)
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Nonaka, S.; Someya, T.; Zhou, S.; Takayama, M.; Nakamura, K.; Ezura, H.
An Agrobacterium tumefaciens strain with gamma-aminobutyric acid transaminase activity shows an enhanced genetic Transformation Ability in Plants
Sci. Rep.
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42649
2017
Agrobacterium tumefaciens (A0A5B8KQ12), Agrobacterium tumefaciens (Q8UBL5), Agrobacterium tumefaciens, Escherichia coli (P22256), Agrobacterium tumefaciens GV2260 (Q8UBL5), Agrobacterium tumefaciens C58 (Q8UBL5)
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