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Literature summary for 2.6.1.19 extracted from

  • Tamaki, N.; Kubo, K.; Aoyama, H.; Funatsuka, A.
    Inhibitory effect of 6-azauracil on purified rabbit liver 4-aminobutyrate aminotransferase (1983), J. Biochem., 93, 955-959.
    View publication on PubMed
Search for more literature for 2.6.1.19

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
 Oryctolagus cuniculus
2-Thiouracil weak Oryctolagus cuniculus
5-Diazouracil weak Oryctolagus cuniculus
5-fluorouracil weak Oryctolagus cuniculus
5-Iodouracil 84% inhibition at 1 mM Oryctolagus cuniculus
5-Nitrouracil weak Oryctolagus cuniculus
5-Thiouracil weak Oryctolagus cuniculus
Aminooxyacetate 99% inhibition at 1 mM Oryctolagus cuniculus
beta-Alanine not Oryctolagus cuniculus
cycloserine 90% inhibition at 1 mM Oryctolagus cuniculus
D-cycloserine
-
 Oryctolagus cuniculus
gabaculine 98% inhibition at 1 mM Oryctolagus cuniculus
glyoxylate weak Oryctolagus cuniculus
additional information no inhibition by 6-azauridine, 6-azauridine 5'-phosphate, uracil, (iso)orotic acid, cytosine, thymine, dihydrothymine, 2-thiocytosine, thiourea; not inhibitory: 5-aminouracil Oryctolagus cuniculus
oxalacetate
-
 Oryctolagus cuniculus
pyruvate
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13 0.27 2-oxoglutarate 37°C, pH 7.3 Oryctolagus cuniculus
18
-
 beta-Alanine
-
 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Renatured (Commentary)

Renatured (Comment) Organism
enzyme inhibited by 6-azauracil is reactivated by dialysis but not by addititon of pyridoxal 5'-phosphate Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
 Oryctolagus cuniculus 4-oxobutanoate + L-glutamate
-
 r
beta-alanine + 2-oxoglutarate
-
 Oryctolagus cuniculus malonic semialdehyde + L-glutamate
-
 r