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Literature summary for 2.6.1.19 extracted from

  • Lu, H.; Silverman, R.B.
    Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors (2006), J. Med. Chem., 49, 7404-7412.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(1R,4S)-4-amino-3-fluorocyclopent-2-enecarboxylic acid weak reversible inhibition in the presence of beta-mercaptoethanol Sus scrofa
(1R,4S)-4-amino-3-pentafluoroethylcyclopent-2-enecarboxylic acid weak reversible inhibition in the presence of beta-mercaptoethanol Sus scrofa
(1R,4S)-4-amino-3-trifluoromethylcyclopent-2-enecarboxylic acid irreversible inhibition in the presence of beta-mercaptoethanol Sus scrofa
(1S,3S)-(Z)-3-amino-4-(2,2,2-trifluoroethylidene)cyclopentanecarboxylic acid inhibition in the presence of beta-mercaptoethanol Sus scrofa
(1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluoromethylethylidene)-cyclopentanecarboxylic acid weak reversible inhibition in the presence of beta-mercaptoethanol Sus scrofa
vigabatrin
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
Sus scrofa 4-oxobutanoate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GABA aminotransferase
-
Sus scrofa
GABA-AT
-
Sus scrofa
gamma-aminobutyric acid aminotransferase
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3
-
(1R,4S)-4-amino-3-fluorocyclopent-2-enecarboxylic acid in potassium diphosphate buffer (pH 8.5) Sus scrofa
2.8
-
(1R,4S)-4-amino-3-pentafluoroethylcyclopent-2-enecarboxylic acid in potassium diphosphate buffer (pH 8.5) Sus scrofa
4.2
-
(1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluoromethylethylidene)-cyclopentanecarboxylic acid in potassium diphosphate buffer (pH 8.5) Sus scrofa