Information on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.2
-
RECOMMENDED NAME
GeneOntology No.
alcohol dehydrogenase (NADP+)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NADP+ = an aldehyde + NADPH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
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redox reaction
reduction
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
ethylene glycol biosynthesis (engineered)
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L-tryptophan degradation X (mammalian, via tryptamine)
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lipid A biosynthesis
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Glycolysis / Gluconeogenesis
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Pentose and glucuronate interconversions
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Glycerolipid metabolism
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Caprolactam degradation
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NADP+ oxidoreductase
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate reductase (NADPH)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-12-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
strain M-1
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
ATCC 8185
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Hartley outbred.
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
cat, mixed breed
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Manually annotated by BRENDA team
chicken
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Manually annotated by BRENDA team
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Swissprot
Manually annotated by BRENDA team
recombinant enzyme expressed in Escherichia coli
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Manually annotated by BRENDA team
Moorella sp.
-
-
-
Manually annotated by BRENDA team
strain B10.A, LP/J, CBAxC57, C57L/J, Nude
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Manually annotated by BRENDA team
C57BL/6
SwissProt
Manually annotated by BRENDA team
strain BCG
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Manually annotated by BRENDA team
sheep; Suffolk-Hampshire
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-
Manually annotated by BRENDA team
mollusc
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
This UniProt-ID has been deleted; NRRL Y-12632
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain AKU 4429
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Manually annotated by BRENDA team
; strain PCC 6803
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Manually annotated by BRENDA team
strain JW200
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Manually annotated by BRENDA team
Thermococcus paravinellae
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Manually annotated by BRENDA team
Thermococcus paravinellae ES-1
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Manually annotated by BRENDA team
strain AN1
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Manually annotated by BRENDA team
strain ES1
UniProt
Manually annotated by BRENDA team
Tulahuen strain, Tul 0 stock
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
mung bean
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-camphorquinoneone + NADPH
? + NADP+
show the reaction diagram
(-)-camphorquinoneone + NADPH
? + NADP+
show the reaction diagram
-
relative activity 2%
-
-
?
(2E)-hex-2-enal + NADPH + H+
(2E)-2-hexen-1-ol + NADP+
show the reaction diagram
-
-
-
-
r
(2E,4E)-hexa-2,4-dienal + NAD(P)H + H+
(2E,4E)-6-hydroxyhexa-2,4-dienal + NAD(P)+
show the reaction diagram
-
-
-
-
-
(2S)-methyl-1-butanol + NADP+
(2S)-methylbutanal + NADPH
show the reaction diagram
-
39% activity compared to cinnamyl alcohol
-
-
r
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzaldehyde) + NADPH + H+
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzyl alcohol) + NADP+
show the reaction diagram
-
eutypine, a toxin produced by Eutypa lata, the causal agent of Eutypa dieback in the grapevine Vitis vinifera
eutypinol, non-toxic metabolite
ir
(R)-1-phenyl-2-propanol + NADP+
phenylacetone + NADPH + H+
show the reaction diagram
-
-
-
-
?
(R)-2-butanol + NADP+
2-butanone + NADPH + H+
show the reaction diagram
the enzyme shows a slight preference for the (S)-2-butanol over (R)-2-butanol
-
-
?
(S)-1-phenyl-2-propanol + NADP+
phenylacetone + NADPH + H+
show the reaction diagram
-
-
-
-
r
(S)-2-butanol + NADP+
2-butanone + NADPH + H+
show the reaction diagram
the enzyme shows a slight preference for the (S)-2-butanol over (R)-2-butanol
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
show the reaction diagram
-
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
-
?
1,2-cyclohexanedione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
1,2-propanediol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
1,3-butanediol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
1,3-propanediol + NADP+
?
show the reaction diagram
-
-
-
-
?
1,3-propanediol + NADP+
? + NADPH
show the reaction diagram
1,4-butanediol + NADP+
?
show the reaction diagram
-
-
-
-
?
1,5-pentanediol + NADP+
?
show the reaction diagram
-
-
-
-
?
1-butanol + NADP+
butanal + NADPH
show the reaction diagram
1-butanol + NADP+
butanal + NADPH + H+
show the reaction diagram
1-butanol + NADP+
butyraldehyde + NADPH + H+
show the reaction diagram
-
-
-
-
r
1-heptanol + NADP+
heptanal + NADPH + H+
show the reaction diagram
1-hexanol + NADP+
hexanal + NADPH
show the reaction diagram
1-hexanol + NADP+
hexanal + NADPH + H+
show the reaction diagram
1-octanol + NADP+
octanal + NADPH
show the reaction diagram
1-octanol + NADP+
octanal + NADPH + H+
show the reaction diagram
1-pentanol + NADP+
n-pentanal + NADPH
show the reaction diagram
1-pentanol + NADP+
n-pentanal + NADPH + H+
show the reaction diagram
-
-
-
-
?
1-pentanol + NADP+
pentanal + NADPH
show the reaction diagram
1-pentanol + NADP+
pentanal + NADPH + H+
show the reaction diagram
1-phenyl-2-butanone + NADPH + H+
(S)-1-phenyl-2-butanol + NADP+
show the reaction diagram
-
-
-
-
?
1-propanol + NADP+
?
show the reaction diagram
-
-
-
-
?
1-propanol + NADP+
propanal + NADPH
show the reaction diagram
-
16% activity compared to cinnamyl alcohol
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r
1-propanol + NADP+
propanal + NADPH + H+
show the reaction diagram
13-cis-retinal + NADPH
13-cis-retinol + NADP+
show the reaction diagram
-
-
-
-
?
2,3-pentanedione + NADPH + H+
? + NADP+
show the reaction diagram
2,4-hexadienal + NADPH
2,4-hexadien-1-ol + NADP+
show the reaction diagram
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-
-
-
?
2,5-hexanedione + NADP+
(2S,5S)-hexanediol + NADPH + H+
show the reaction diagram
-
-
-
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r
2-(S)-methylbutanol + NADP+
(2S)-2-methylbutanal + NADPH
show the reaction diagram
-
7% of activity with cinnamyl alcohol
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r
2-butanol + NADP+
2-butanone + NADPH
show the reaction diagram
-
2% of activity with cinnamyl alcohol
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r
2-butanol + NADP+
?
show the reaction diagram
2-butanol + NADP+
butan-2-one + NADPH
show the reaction diagram
2-butanol + NADP+
butanone + NADPH
show the reaction diagram
-
1% activity compared to cinnamyl alcohol
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r
2-butanone + NADP+
2-butanol + NADPH + H+
show the reaction diagram
-
-
-
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r
2-chloroheptanal + NADPH
2-chloroheptanol + NADP+
show the reaction diagram
-
-
-
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r
2-decanone + NADPH
2-decanol + NADP+
show the reaction diagram
-
-
-
-
?
2-heptanol + NADP+
heptan-2-one + NADPH
show the reaction diagram
-
-
-
-
r
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
show the reaction diagram
2-methyl-1-propanol + NADP+
2-methylpropanal + NADPH
show the reaction diagram
2-methylbutanal + NADPH
2-methyl-1-butanol + NADP+
show the reaction diagram
2-methylbutanal + NADPH
2-methylbutanol + NADP+
show the reaction diagram
-
-
-
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r
2-methylbutanol + NADP+
2-methylbutyraldehyde + NADPH + H+
show the reaction diagram
-
24% activity with 1 mM 2-methylbutanol, 22% activity with 10 mM 2-methylbutanol
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r
2-methylbutanol + NADP+
? + NADPH + H+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 24% relative activity with 1 mM or 22% relative activity with 10 mM substrate
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-
?
2-methylpropanal + NADPH
2-methyl-1-propanol + NADP+
show the reaction diagram
2-methylpropanol + NADP+
2-methylpropanal + NADPH
show the reaction diagram
-
1% of activity with cinnamyl alcohol
-
-
r
2-methylundecanal + NADPH
2-methylundecanol + NADP+
show the reaction diagram
-
-
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
show the reaction diagram
maximal activity in oxidative reaction
-
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r
2-pentanol + NADP+
pentan-2-one + NADPH
show the reaction diagram
-
-
-
-
r
2-pentanol + NADP+
pentan-2-one + NADPH + H+
show the reaction diagram
-
67% of the activity with 2-propanol
-
-
?
2-pentanone + NADP+
2-pentanol + NADPH + H+
show the reaction diagram
-
-
-
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r
2-phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
show the reaction diagram
Thermococcus paravinellae
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-
-
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r
2-phenylethanol + NADP+
2-phenylacetaldehyde + NADPH + H+
show the reaction diagram
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH
show the reaction diagram
-
23% activity compared to cinnamyl alcohol
-
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r
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
show the reaction diagram
2-propanol + NADP+
acetone + NADPH
show the reaction diagram
2-propanol + NADP+
acetone + NADPH + H+
show the reaction diagram
2-propanone + NADP+
2-propanol + NADPH + H+
show the reaction diagram
-
-
-
-
r
2-propen-1-ol + NADP+
acrylaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
3,4-dihydro-1(2H)-naphthalenone + NADPH + H+
1,2,3,4-tetrahydronaphthalen-1-ol + NADP+
show the reaction diagram
3,4-dihydroxyphenylacetaldehyde + NADPH + H+
3,4-dihydroxyphenylethanol + NADP+
show the reaction diagram
-
-
-
-
r
3,4-dihydroxyphenylglycolaldehyde + NADPH
? + NADP+
show the reaction diagram
3-cyanobenzaldehyde + NADPH
3-cyanobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
3-deoxyglucosone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
3-heptanone + NADPH
3-heptanol + NADP+
show the reaction diagram
-
-
-
-
?
3-hexanol + NADP+
hexan-3-one + NADPH
show the reaction diagram
-
-
-
-
r
3-methyl-1-butanol + NADP+
3-methylbutanal + NADPH
show the reaction diagram
-
40% activity compared to cinnamyl alcohol
-
-
r
3-methylbutanal + NADPH
3-mehtyl-1-butanol + NADP+
show the reaction diagram
-
84% of activity with cinnamaldehyde
-
-
r
3-methylbutanal + NADPH
3-methyl-1-butanol + NADP+
show the reaction diagram
-
79% activity compared to cinnamaldehyde
-
-
r
3-methylbutanal + NADPH
3-methylbutanol + NADP+
show the reaction diagram
-
-
-
-
r
3-methylbutanol + NADP+
3-methylbutanal + NADPH
show the reaction diagram
-
15% of activity with cinnamyl alcohol
-
-
r
3-octanone + NADPH
3-octanol + NADP+
show the reaction diagram
-
-
-
-
?
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
show the reaction diagram
3-pyridinemethanol + NADP+
3-pyridinecarboxaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
4-benzoylpyridine + ?
?
show the reaction diagram
-
-
-
-
r
4-carboxyacetophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-carboxyphenylglyoxal + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-hydroxy-3-methoxybenzyl alcohol + NADP+
4-hydroxy-3-methoxybenzaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
4-hydroxy-3-methoxyphenethylene glycol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
4-hydroxybenzaldehyde + NADPH + H+
4-hydroxybenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
4-hydroxybutyrate + NADP+
4-ketobutyrate + NADPH
show the reaction diagram
-
-
-
-
r
4-hydroxynonenal + NADPH
4-hydroxynonenol + NADP+
show the reaction diagram
-
30% of activity with cinnamaldehyde
-
-
r
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
show the reaction diagram
4-methylbenzyl alcohol + NADP+
4-methylbenzaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
4-nitroacetophenone + NADPH
1-(4-nitrophenyl)ethanol + NADP+
show the reaction diagram
-
-
-
-
?
4-phenyl-2-butanone + NADPH + H+
(S)-4-phenyl-2-butanol + NADP+
show the reaction diagram
-
-
-
-
?
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
show the reaction diagram
5-(hydroxymethyl)furan-2-carbaldehyde + NADPH + H+
(furan-2,5-diyl)dimethanol + NADP+
show the reaction diagram
5-hydroxyindoleacetaldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
9-cis-retinal + NADPH
9-cis-retinol + NADP+
show the reaction diagram
-
-
-
-
r
9-cis-retinol + NADP+
9-cis-retinal + NADPH
show the reaction diagram
-
-
-
-
r
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly + NADH + H+
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly-al + NADPH + H+
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-S-CoA + NADPH + H+
?
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu- + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe-ol + NADP+
show the reaction diagram
-
-
-
-
-
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly- + NADH + H+
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly-al + NAD+ + H2O
show the reaction diagram
-
-
-
-
-
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly-al + NADPH + H+
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly-ol + NADP+
show the reaction diagram
-
-
-
-
-
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
acetoin + NADPH + H+
butan-2,3-diol + NADP+
show the reaction diagram
-
isozyme AR3
-
-
?
acetone + NADPH
2-propanol + NADP+
show the reaction diagram
-
-
-
-
?
acetone + NADPH + H+
propan-2-ol + NADP+
show the reaction diagram
-
about 13% of the activity with butan-2-ol
-
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
show the reaction diagram
-
recombinant mutant G37D
recombinate mutant G37D
-
r
acetophenone + NADPH
(R)-1-phenylethanol + NADP+
show the reaction diagram
-
catalysed by Escherichia coli coexpressing enzyme with NAD+-dependent formate dehydrogenase and pyridine nucleotide transhydrogenase genes pnta and pntb
-
-
?
acetophenone + NADPH
1-phenylethanol + NADP+
show the reaction diagram
-
-
-
-
?
acetophenone + NADPH + H+
(S)-1-phenylethanol + NADP+
show the reaction diagram
-
-
-
-
r
acetophenone + NADPH + H+
1-phenylethanol + NADP+
show the reaction diagram
-
recombinant wild-type
recombinant wild-type
-
r
acetyl-CoA + NADPH
acetaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
-
?
acrolein + NADPH
propenol + NADP+
show the reaction diagram
-
-
-
-
r
adonitol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
aldehyde + NADPH + H+
alcohol + NADP+
show the reaction diagram
-
the physiological role of this enzyme is likely to catalyze the reduction of aldehydes to alcohols
-
-
?
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
show the reaction diagram
-
-
-
-
r
all-trans-retinol + NADP+
all-trans-retinal + NADPH
show the reaction diagram
-
-
-
-
r
allactose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
alpha-diketone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
androstane-3,17-dione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
anisaldehyde + NADPH
4-methoxybenzyl alcohol + NADP+
show the reaction diagram
anisaldehyde + NADPH + H+
anisyl alcohol + NADP+
show the reaction diagram
anisyl alcohol + NADP+
anisaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
benzalacetone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
show the reaction diagram
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 30% relative activity with 0.1 mM or 14% relative activity with 1 mM substrate
-
-
r
benzoic aldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH
show the reaction diagram
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
show the reaction diagram
butan-1-ol + NADP+
butanal + NADPH + H+
show the reaction diagram
butan-2-ol + NADP+
butanone + NADPH + H+
show the reaction diagram
butanal + NADPH + H+
1-butanol + NADP+
show the reaction diagram
butanal + NADPH + H+
butan-1-ol + NADP+
show the reaction diagram
butanal + NADPH + H+
butanol + NADP+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 73% relative activity with 0.1 mM or 120% relative activity with 1 mM substrate
-
-
r
butanaldehyde + NADPH
butanol + NADP+
show the reaction diagram
-
-
-
-
r
butane 2,3-dione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
butane-1,2-diol + NADP+
butanal-2-ol + NADPH
show the reaction diagram
-
2% activity compared to cinnamyl alcohol
-
-
r
butane-1,3-diol + NADP+
butanal-3-ol + NADPH
show the reaction diagram
-
5% activity compared to cinnamyl alcohol
-
-
r
butane-1,4-diol + NADP+
butanal-4-ol + NADPH
show the reaction diagram
-
8% activity compared to cinnamyl alcohol
-
-
r
butanol + NADP+
butanal + NADPH
show the reaction diagram
butanol + NADP+
butanal + NADPH + H+
show the reaction diagram
butanone + NADPH + H+
butan-2-ol + NADP+
show the reaction diagram
-
-
-
-
r
butyraldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
cellobiose + NADP+
? + NADPH + H+
show the reaction diagram
chloral hydrate + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
cinnamaldehyde + NADPH
cinnamic alcohol + NADP+
show the reaction diagram
5% of activity with acetaldehyde
-
-
r
cinnamaldehyde + NADPH
cinnamyl alcohol + NADP+
show the reaction diagram
-
-
-
-
r
cinnamaldehyde + NADPH + H+
cinnamyl alcohol + NADP+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 61% relative activity with 0.1 mM or 7% relative activity with 1 mM substrate
-
-
r
cinnamic aldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
cinnamyl alcohol + NADP+
cinnamaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
cinnamyl alcohol + NADP+
cinnamaldehyde + NADPH + H+
show the reaction diagram
cinnamyl alcohol + NADP+
cinnamylaldehyde + NADPH
show the reaction diagram
-
-
-
-
r
cis-11-hexadecenal + NADPH
cis-11-hexadecenol + NADP+
show the reaction diagram
-
87% relative activity
-
-
ir
coniferaldehyde + NADPH
coniferyl alcohol + NADP+
show the reaction diagram
coniferyl alcohol + NADP+
coniferaldehyde + NADPH + H+
show the reaction diagram
-
7% activity compared to cinnamyl alcohol
-
-
r
coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
show the reaction diagram
-
27% of activity with cinnamyl alcohol
-
-
r
cyclohexancarbaldehye + NADPH
cyclohexanol + NADP+
show the reaction diagram
3% of activity with acetaldehyde
-
-
r
cyclohexanol + NADP+
cyclohexanal + NADPH
show the reaction diagram
-
-
-
-
r
cyclohexanol + NADP+
cyclohexancarbaldehyde + NADPH
show the reaction diagram
14% of activity with ethanol
-
-
r
cyclohexanol + NADP+
cyclohexanone + NADPH + H+
show the reaction diagram
-
about 15% of the activity with butan-2-ol
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
cyclopentanol + NADP+
cyclopentanal + NADPH
show the reaction diagram
-
-
-
-
r
D-arabinose + NADP+
D-arabitol + NADPH + H+
show the reaction diagram
-
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
-
?
D-arabinose + NADPH
? + NADP+
show the reaction diagram
D-arabitol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
D-erythrose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-fructose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-galactose + NADPH
? + NADP+
show the reaction diagram
D-galacturonate + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-glucose + NADP+
? + NADPH + H+
show the reaction diagram
D-glucose + NADPH
? + NADP+
show the reaction diagram
D-glucuronate + NADPH
?
show the reaction diagram
D-glucuronate + NADPH
L-gulonate + NADP+
show the reaction diagram
D-glucuronate + NADPH + H+
?
show the reaction diagram
D-glucuronolactone + NADPH
? + NADP+
show the reaction diagram
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
D-lactaldehyde + NADPH + H+
propane-1,2-diol + NADP+
show the reaction diagram
D-ribose + NADPH
? + NADP+
show the reaction diagram
D-sorbitol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
D-xylose + NADP+
? + NADPH + H+
show the reaction diagram
-
246% of the activity with 2-propanol
-
-
?
D-xylose + NADPH
? + NADP+
show the reaction diagram
daunorubicin + NADPH
? + NADP+
show the reaction diagram
decanal + NADPH
decanol + NADP+
show the reaction diagram
-
no detectable catalysis of the reverse reaction, the oxidation of decanol by NADP+. 100% relative activity
-
-
ir
decanal + NADPH + H+
decanol + NADP+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 21% relative activity with 0.1 mM or 22% relative activity with 1 mM substrate
-
-
r
decanol + NADP+
decanal + NADPH + H+
show the reaction diagram
dehydro-L-ascorbate + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
diacetyl + NADPH
? + NADP+
show the reaction diagram
dimethylglyoxal + NADPH + H+
? + NADP+
show the reaction diagram
-
270% of the activity with pyruvaldehyde
-
-
?
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
dodecanal + NADPH
dodecanol + NADP+
show the reaction diagram
-
55% relative activity
-
-
ir
erythritol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
ethanol + NADP+
acetaldehyde + NADPH + H+
show the reaction diagram
ethyl 4-bromo-3-oxobutanoate + NADPH
(R)-4-bromo-3-hydroxybutanoic acid ethyl ester + NADP+
show the reaction diagram
-
-
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADPH + H+
(R)-4-chloro-3-hydroxybutanoic acid ethyl ester + NADP+
show the reaction diagram
-
-
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADPH + H+
ethyl (S)-4-chloro-3-hydroxybutanoate + NADP+
show the reaction diagram
ethyl-4-chloro-3-oxobutanoate + NADPH + H+
ethyl-4-chloro-3-hydroxybutanoate + NADP+
show the reaction diagram
ethylacetoacetate + NADPH
ethyl L-(+)-3-hydroxybutyrate + NADP+
show the reaction diagram
ethylene glycol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
formaldehyde + NADPH
methanol + NADP+
show the reaction diagram
furaldehyde + NADPH
furfuryl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
furan-2-carbaldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
furfural + NADPH
furfuryl alcohol + NADP+
show the reaction diagram
glucuronate + NADPH
?
show the reaction diagram
glucuronate + NADPH + H+
?
show the reaction diagram
glutaraldehyde + NADPH
? + NADP+
show the reaction diagram
5% of activity with acetaldehyde
-
-
r
glycerol + NADP+
DL-glyceraldehyde + NADPH
show the reaction diagram
glycolaldehyde + NADPH
ethane-1,2-diol + NADP+
show the reaction diagram
heptanal + NADPH
1-heptanol + NADP+
show the reaction diagram
heptanal + NADPH + H+
heptanol + NADP+
show the reaction diagram
-
-
-
-
?
heptanaldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
hexadecanol + NADP+
hexadecanal + NADPH
show the reaction diagram
-
-
-
-
r
hexan-1-ol + NADP+
hexanal + NADPH + H+
show the reaction diagram
hexanal + NADPH + H+
1-hexanol + NADP+
show the reaction diagram
hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
hexanal + NADPH + H+
n-hexanol + NADP+
show the reaction diagram
-
-
-
-
?
hexanaldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
hexanol + NADP+
hexanal + NADPH
show the reaction diagram
hexanol + NADP+
hexanal + NADPH + H+
show the reaction diagram
hexyl alcohol + NADP+
?
show the reaction diagram
the native enzyme shows 137.8% activity with hexyl alcohol compared to ethanol
-
-
?
hexyl alcohol + NADP+
hexanal + NADPH + H+
show the reaction diagram
-
-
-
-
?
hydroxyindol-3-ylacetaldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
hydroxypyruvate + ?
?
show the reaction diagram
-
-
-
-
r
indol-3-ylacetaldehyde + NADPH
indol-3-ethanol + NADP+
show the reaction diagram
indolacetaldehyde sodium bisulfate complex + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
iodoacetaldehyde + NADPH
iodoethan-2-ol + NADP+
show the reaction diagram
-
-
-
-
r
iodohexadecanal + NADPH
iodohexadecanol + NADP+
show the reaction diagram
-
-
-
-
r
isoamyl alcohol + NADP+
3-methylbutanol + NADPH
show the reaction diagram
18% of activity with ethanol
-
-
r
isobutanol + NADP+
isobutanal + NADPH + H+
show the reaction diagram
isobutanol + NADP+
isobutanol + NADPH + H+
show the reaction diagram
Thermococcus paravinellae
-
93% of the activity with ethanol
-
-
r
isobutanol + NADP+
isobutyl aldehyde + NADPH + H+
show the reaction diagram
Moorella sp.
-
isoform AdhA, 221% of the activity with acetaldehyde
-
-
r
isobutyl aldehyde + NADPH + H+
isobutanol + NADP+
show the reaction diagram
Moorella sp.
-
isoform AdhA, 469%, isoform AdhB, 48% of the activity with acetaldehyde
-
-
r
isopentanol + NADP+
3-methylbutanal + NADPH + H+
show the reaction diagram
9% of activity with ethanol
-
-
r
isopropanol + NADP+
acetone + NADPH
show the reaction diagram
2% of activity with ethanol
-
-
r
L-arabitol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
show the reaction diagram
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
show the reaction diagram
L-sorbose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
L-xylose + NADPH
? + NADP+
show the reaction diagram
lauryl aldehyde + NADPH
lauryl alcohol + NADP+
show the reaction diagram
m-chlorobenzaldehyde + NADPH + H+
m-chlorobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
r
m-fluorobenzaldehyde + NADPH + H+
m-fluorobenzyl alcohol + NADP+
show the reaction diagram
m-methoxybenzaldehyde + NADPH + H+
m-methoxybenzyl alcohol + NADP+
show the reaction diagram
m-methylbenzaldehyde + NADPH
m-methylbenzyl alcohol + NADP+
show the reaction diagram
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
show the reaction diagram
malondialdehyde + NADPH
?
show the reaction diagram
-
-
-
-
r
menadione + NADPH
? + NADP+
show the reaction diagram
-
G2
-
-
?
methanol + NADP+
formaldehyde + NADPH + H+
show the reaction diagram
-
-
-
-
r
methyl 4-bromo-3-oxobutanoate + NADPH + H+
methyl (S)-4-bromo-3-hydroxybutanoate + NADP+
show the reaction diagram
methyl acetoacetate + NADH + H+
methyl (R)-3-hydroxy-butanoate + NAD+
show the reaction diagram
-
-
-
-
?
methyl acetoacetate + NADPH + H+
methyl (R)-3-hydroxy-butanoate + NADP+
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
methylglyoxal + NADPH
? + NADP+
show the reaction diagram
mevaldate + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
n-butanol + NADP+
butyraldehyde + NADPH
show the reaction diagram
n-butyraldehyde + NADPH
n-butanol + NADP+
show the reaction diagram
n-decanal + NADPH + H+
n-decanol + NADP+
show the reaction diagram
n-dodecanal + NADPH + H+
n-dodecanol + NADP+
show the reaction diagram
n-heptanal + NADPH
heptanol + NADP+
show the reaction diagram
n-heptanol + NADP+
n-heptanal + NADPH
show the reaction diagram
n-hexadecanal + NADPH + H+
n-hexadecanol + NADP+
show the reaction diagram
n-hexanol + NADP+
n-hexanal + NADPH
show the reaction diagram
n-octadecanal + NADPH + H+
n-octadecanol + NADP+
show the reaction diagram
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
show the reaction diagram
n-propanol + NADP+
propionaldehyde + NADPH
show the reaction diagram
n-tetradecanal + NADPH + H+
n-tetradecanol + NADP+
show the reaction diagram
-
-
-
-
r
nonanal + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
o-fluorobenzaldehyde + NADPH + H+
o-fluorobenzyl alcohol + NADP+
show the reaction diagram
o-methylbenzaldehyde + NADPH
o-methylbenzyl alcohol + NADP+
show the reaction diagram
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
show the reaction diagram
octan-1-ol + NADP+
octanal + NADPH + H+
show the reaction diagram
octanal + NADPH + H+
1-octanol + NADP+
show the reaction diagram
octanal + NADPH + H+
octanol + NADP+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 42% relative activity with 0.1 mM or 80% relative activity with 1 mM substrate
-
-
r
octanaldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
octanol + NADP+
octanal + NADPH
show the reaction diagram
-
52% of activity with cinnamyl alcohol
-
-
r
octanol + NADP+
octanal + NADPH + H+
show the reaction diagram
octyl 4-chloro-3-oxobutanoate + NADPH
(R)-4-chloro-3-hydroxybutanoic acid ethyl ester + NADP+
show the reaction diagram
-
-
-
-
?
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
show the reaction diagram
p-chlorobenzaldehyde + NADPH + H+
p-chlorobenzyl alcohol + NADP+
show the reaction diagram
p-cyanobenzaldehyde + NADPH
p-cyanobenzyl alcohol + NADP+
show the reaction diagram
p-fluorobenzaldehyde + NADPH + H+
p-fluorobenzyl alcohol + NADP+
show the reaction diagram
p-hydroxyphenylacetaldehyde + NADPH + H+
p-hydroxyphenylethanol + NADP+
show the reaction diagram
p-hydroxyphenylglycolaldehyde + NADPH
4-hydroxyphenylethylalcohol + NADP+
show the reaction diagram
p-methoxybenzaldehyde + NADPH + H+
p-methoxybenzyl alcohol + NADP+
show the reaction diagram
p-methylbenzaldehyde + NADPH
p-methylbenzyl alcohol + NADP+
show the reaction diagram
p-nitroacetophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
show the reaction diagram
p-tolualdehyde + NADPH
toluol + NADP+
show the reaction diagram
-
-
-
-
?
pent-1-en-3-ol + NADP+
pent-1-en-3-one + NADPH + H+
show the reaction diagram
-
good substrate
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH + H+
show the reaction diagram
pentanal + NADPH
1-pentanol + NADP+
show the reaction diagram
pentanal + NADPH
pentanol + NADP+
show the reaction diagram
pentanal + NADPH + H+
pentanol + NADP+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 100% relative activity with 0.1 mM or 107% relative activity with 1 mM substrate
-
-
r
pentanol + NADP+
pentanal + NADPH
show the reaction diagram
pentanol + NADP+
pentanal + NADPH + H+
show the reaction diagram
phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
show the reaction diagram
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
show the reaction diagram
phenylacetone + NADPH + H+
(S)-1-phenyl-2-propanol + NADP+
show the reaction diagram
-
-
-
-
r
phenylethanol + NADP+
? + NADPH + H+
show the reaction diagram
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 15% relative activity with 1 mM or 24% relative activity with 10 mM substrate
-
-
?
phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
show the reaction diagram
-
15% activity with 1 mM phenylethanol, 24% activity with 10 mM phenylethanol
-
-
r
phenylethylamine + ?
?
show the reaction diagram
-
-
-
-
r
phenylglyoxal + NADPH
? + NADP+
show the reaction diagram
propan-1-ol + NADP+
propanal + NADPH + H+
show the reaction diagram
propan-2-ol + NADP+
acetone + NADPH + H+
show the reaction diagram
-
good substrate
-
-
?
propan-2-ol + NADP+
propanone + NADPH
show the reaction diagram
propanal + NADPH + H+
1-propanol + NADP+
show the reaction diagram
propanal + NADPH + H+
propan-1-ol + NADP+
show the reaction diagram
Moorella sp.
-
isoform AdhA, 50%, isoform AdhB, 62% of the activity with acetaldehyde
-
-
r
propanal + NADPH + H+
propanol + NADP+
show the reaction diagram
propanaldehyde + NADPH
propanol + NADP+
show the reaction diagram
-
-
-
-
r
propane-1,2-diol + NADP+
lactaldehyde + NADPH
show the reaction diagram
propanol + NADP+
propanal + NADPH
show the reaction diagram
propanol + NADP+
propanal + NADPH + H+
show the reaction diagram
-
21% activity with 1 mM propanol, 84% activity with 10 mM propanol
26% activity with 0.1 mM propanal, 87% activity with 1 mM propanal
-
r
propionaldehyde + NADPH
propanol + NADP+
show the reaction diagram
propionaldehyde + NADPH + H+
propanol + NADP+
show the reaction diagram
-
-
-
-
?
propiophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
pyridoxal + NADPH
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol + NADP+
show the reaction diagram
-
-
-
-
?
pyruvaldehyde + NADP+
? + NADPH + H+
show the reaction diagram
-
-
-
-
r
pyruvaldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
show the reaction diagram
pyruvate + NADPH
2-hydroxypropanoic acid + NADP+
show the reaction diagram
-
-
-
-
?
salicylaldehyde + NADPH
2-hydroxymethylphenol + NADP+
show the reaction diagram
-
-
-
-
?
salicylaldehyde + NADPH
salicylalcohol + NADP+
show the reaction diagram
1% of activity with acetaldehyde
-
-
r
salicylaldehyde + NADPH
salicylic alcohol + NADP+
show the reaction diagram
-
-
-
-
?
sinapaldehyde + NADPH + H+
sinapyl alcohol + NADP+
show the reaction diagram
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
show the reaction diagram
tetradecanal + NADPH
tetradecanol
show the reaction diagram
-
-
-
-
r
trans-2-decenal + NADPH
trans-2-decen-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
trans-2-hexenal + NADPH
trans-2-hexen-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
trans-2-hexenol + NADP+
trans-2-hexenal + NADPH
show the reaction diagram
trans-2-nonenal + NADPH
trans-2-nonen-1-ol + NADP+
show the reaction diagram
-
33% activity compared to cinnamaldehyde
-
-
r
trans-2-nonenal + NADPH
trans-2-nonenol + NADP+
show the reaction diagram
-
39% of activity with cinnamaldehyde
-
-
r
trans-2-nonenaldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
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trans-cinnamaldehyde + NADPH
cinnamyl alcohol + NADP+
show the reaction diagram
tridecanal + NADPH
tridecanol + NADP+
show the reaction diagram
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r
Tris + NADP+
? + NADPH
show the reaction diagram
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?
undecanal + NADPH
undecanol + NADP+
show the reaction diagram
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?
valeraldehyde + NADPH + H+
? + NADP+
show the reaction diagram
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?
vanillin + NADPH
4-hydroxy-3-methoxybenzyl alcohol + NADP+
show the reaction diagram
veratraldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
show the reaction diagram
vitamin A aldehyde + NADPH
? + NADP+
show the reaction diagram
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?
additional information
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