Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1H-indol-1-yl)acetic acid | - |
Rattus norvegicus | |
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid | - |
Rattus norvegicus | |
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | - |
Rattus norvegicus | |
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | - |
Rattus norvegicus | |
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | - |
Rattus norvegicus | |
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid | - |
Rattus norvegicus | |
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid | - |
Rattus norvegicus | |
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid | - |
Rattus norvegicus | |
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | - |
Rattus norvegicus | |
2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione | - |
Rattus norvegicus | |
3-(1H-indol-1-yl)propanoic acid | - |
Rattus norvegicus | |
3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid | - |
Rattus norvegicus | |
lidorestat | binding mode, overview | Rattus norvegicus | |
additional information | identification of aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold, the compouds have also lower inhibitory potency against aldehyde reductase, structure-activity relationships, overview | Rattus norvegicus | |
[(5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetic acid | - |
Rattus norvegicus | |
[3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid | - |
Rattus norvegicus | |
[3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid | - |
Rattus norvegicus | |
[3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid | - |
Rattus norvegicus | |
[3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid | - |
Rattus norvegicus | |
[3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid | - |
Rattus norvegicus | |
[3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH + H+ | Rattus norvegicus | - |
? + NADP+ | - |
r | |
D-glucuronate + NADPH + H+ | Rattus norvegicus Wistar | - |
? + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P07943 | - |
- |
Rattus norvegicus Wistar | P07943 | - |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially from lens and kidney | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
lens | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
r | |
D-glucuronate + NADPH + H+ | - |
Rattus norvegicus Wistar | ? + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
AKR1A1 | - |
Rattus norvegicus |
aldehyde reductase | - |
Rattus norvegicus |
ALR1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | |
0.0048 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid | |
0.0067 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid | |
0.0118 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-(1H-indol-1-yl)propanoic acid | |
0.0141 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid | |
0.0151 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid | |
0.0192 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid | |
0.0196 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | |
0.0223 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid | |
0.0235 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | |
0.0248 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid | |
0.0325 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid | |
0.0381 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid | |
0.0406 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | |
0.049 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid | |
0.0684 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid | |
0.0802 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (1H-indol-1-yl)acetic acid |