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Literature summary for 1.1.1.2 extracted from
- Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain (1986), J. Biochem., 99, 513-519.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
hexadecanal | - |
Rattus norvegicus |  |
| 0.21 | - |
octanal | - |
Rattus norvegicus | |
| 0.31 | - |
p-nitrobenzaldehyde | - |
Rattus norvegicus | |
| 1.4 | - |
4-Nitroacetophenone | - |
Rattus norvegicus | |
| 2.5 | - |
Benzalacetone | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
- |
Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 20 | - |
p-nitrobenzaldehyde as substrate | Rattus norvegicus |
| 211 | - |
hexadecanal as substrate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitroacetophenone + NADPH + H+ | - |
Rattus norvegicus | 1-(4-nitrophenyl)ethanol + NADP+ | - |
r | |
| 4-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 4-pyridinemethanol + NADP+ | - |
r | |
| 4-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus Wistar | 4-pyridinemethanol + NADP+ | - |
r | |
| benzalacetone + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
| additional information | enzyme from rat brain microsomes do not reduce p-pyridinecarboxaldehyde, which is a very active substrate for high-Km aldehyde reductase from rat kidney cytosol | Rattus norvegicus | ? | - |
? | |
| additional information | enzyme from rat brain microsomes do not reduce p-pyridinecarboxaldehyde, which is a very active substrate for high-Km aldehyde reductase from rat kidney cytosol | Rattus norvegicus Wistar | ? | - |
? | |
| n-hexadecanal + NADPH + H+ | - |
Rattus norvegicus | n-hexadecanol + NADP+ | - |
r | |
| n-hexadecanal + NADPH + H+ | - |
Rattus norvegicus Wistar | n-hexadecanol + NADP+ | - |
r | |
| n-octadecanal + NADPH + H+ | - |
Rattus norvegicus | n-octadecanol + NADP+ | - |
r | |
| n-octanal + NADPH + H+ | - |
Rattus norvegicus | n-octanol + NADP+ | - |
? | |
| n-octanal + NADPH + H+ | - |
Rattus norvegicus Wistar | n-octanol + NADP+ | - |
? | |
| p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus Wistar | p-nitrobenzylalcohol + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NADPH-cytochrome c reductase | - |
Rattus norvegicus |
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