Any feedback?
Literature summary for 1.1.1.2 extracted from
- Triphosphopyridine nucleotide-linked aldehyde reductase I. Purification and properties of the enzyme from pig kidney cortex (1972), J. Biol. Chem., 217, 4480-4485.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| PO43- | stimulates the enzymatic reduction of 3-pyridinecarboxaldehyde | Sus scrofa |  |
| SO42- | stimulates the enzymatic reduction of 3-pyridinecarboxaldehyde | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Amobarbital | - |
Sus scrofa | |
| hydroxylamine | - |
Sus scrofa | |
| iodoacetic acid | - |
Sus scrofa | |
| Sodium fluoride | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.078 | - |
p-Carboxybenzaldehyde | - |
Sus scrofa | |
| 0.33 | - |
(+)-Camphorquinone | - |
Sus scrofa | |
| 0.35 | - |
p-nitrobenzaldehyde | - |
Sus scrofa | |
| 0.51 | - |
p-cyanobenzaldehyde | - |
Sus scrofa | |
| 0.69 | - |
4-Pyridinecarboxaldehyde | - |
Sus scrofa | |
| 2.6 | - |
3-Pyridinecarboxaldehyde | - |
Sus scrofa | |
| 5.5 | - |
3-Pyridinemethanol | - |
Sus scrofa | |
| 775 | - |
glycerol | - |
Sus scrofa | |
| 1360 | - |
L-arabitol | - |
Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
gel filtration, ultracentrifugation, specific activity corresponding to molecular weight | Sus scrofa |
| 30200 | - |
gel filtration, sedimentation equilibrium determination | Sus scrofa |
| 38000 | - |
1 * 38000, SDS-PAGE | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-diketone + NADPH | Sus scrofa | - |
? + NADP+ | - |
? | |
| D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Sus scrofa | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Oryctolagus cuniculus | - |
L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Oryctolagus cuniculus | - |
glycerol + NADP+ | - |
r | |
| L-gulonic acid + NADP+ | Rattus norvegicus | - |
D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | Sus scrofa | - |
D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | Bos taurus | - |
D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | Oryctolagus cuniculus | - |
D-glucuronic acid + NADPH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Rattus norvegicus | - |
rat | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Bos taurus | - |
| kidney | cortex | Sus scrofa | - |
| kidney | cortex | Oryctolagus cuniculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 17.1 | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stable for several months if stored as an ammonium sulfate precipitate | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+)-camphorquinone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| (-)-camphorquinone + NADPH | relative activity 2% | Sus scrofa | ? + NADP+ | - |
? | |
| 2,3-pentanedione + NADPH + H+ | - |
Sus scrofa | ? + NADP+ | - |
? | |
| 3-cyanobenzaldehyde + NADPH | - |
Sus scrofa | 3-cyanobenzyl alcohol + NADP+ | - |
? | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Oryctolagus cuniculus | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinemethanol + NADP+ | - |
Sus scrofa | 3-pyridinecarboxaldehyde + NADPH | - |
r | |
| 4-methylbenzyl alcohol + NADP+ | - |
Sus scrofa | 4-methylbenzaldehyde + NADPH + H+ | - |
r | |
| 4-nitroacetophenone + NADPH | - |
Sus scrofa | 1-(4-nitrophenyl)ethanol + NADP+ | - |
? | |
| 4-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 4-pyridinemethanol + NADP+ | - |
r | |
| 4-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 4-pyridinemethanol + NADP+ | - |
r | |
| 4-pyridinecarboxaldehyde + NADPH | - |
Oryctolagus cuniculus | 4-pyridinemethanol + NADP+ | - |
r | |
| acetaldehyde + NADPH + H+ | - |
Rattus norvegicus | ethanol + NADP+ | - |
? | |
| acetaldehyde + NADPH + H+ | - |
Sus scrofa | ethanol + NADP+ | - |
? | |
| adonitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
| allactose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| alpha-diketone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| anisaldehyde + NADPH + H+ | - |
Sus scrofa | anisyl alcohol + NADP+ | - |
r | |
| anisyl alcohol + NADP+ | - |
Sus scrofa | anisaldehyde + NADPH | - |
r | |
| benzaldehyde + NADPH | - |
Rattus norvegicus | benzyl alcohol + NADP+ | - |
r | |
| benzaldehyde + NADPH | - |
Bos taurus | benzyl alcohol + NADP+ | - |
r | |
| benzaldehyde + NADPH | relative activity 4% | Sus scrofa | benzyl alcohol + NADP+ | - |
r | |
| benzyl alcohol + NADP+ | - |
Sus scrofa | benzaldehyde + NADPH | - |
r | |
| cyclohexanone + NADPH | - |
Sus scrofa | cyclohexanol + NADP+ | - |
? | |
| cyclohexanone + NADPH | - |
Bos taurus | cyclohexanol + NADP+ | - |
? | |
| D-arabinose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
| D-arabitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
| D-erythrose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-fructose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-galactose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-glucose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Oryctolagus cuniculus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Oryctolagus cuniculus | L-gulonate + NADP+ | - |
r | |
| D-glucuronolactone + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
| D-glucuronolactone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Oryctolagus cuniculus | glycerol + NADP+ | - |
r | |
| D-lactaldehyde + NADPH + H+ | - |
Sus scrofa | propane-1,2-diol + NADP+ | - |
r | |
| D-lactaldehyde + NADPH + H+ | - |
Bos taurus | propane-1,2-diol + NADP+ | - |
r | |
| D-ribose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-sorbitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
| D-xylose + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
| D-xylose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-xylose + NADPH | - |
Bos taurus | ? + NADP+ | - |
? | |
| dehydro-L-ascorbate + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| diacetyl + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| erythritol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
| glycerol + NADP+ | - |
Rattus norvegicus | DL-glyceraldehyde + NADPH + H+ | - |
r | |
| glycerol + NADP+ | - |
Sus scrofa | DL-glyceraldehyde + NADPH + H+ | - |
r | |
| indolacetaldehyde + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| L-arabitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
| L-gulonic acid + NADP+ | - |
Rattus norvegicus | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | - |
Sus scrofa | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | - |
Bos taurus | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | - |
Oryctolagus cuniculus | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADPH | - |
Rattus norvegicus | D-glucuronic acid + NADP+ | - |
r | |
| L-gulonic acid + NADPH | - |
Sus scrofa | D-glucuronic acid + NADP+ | - |
r | |
| L-gulonic acid + NADPH | - |
Bos taurus | D-glucuronic acid + NADP+ | - |
r | |
| L-gulonic acid + NADPH | - |
Oryctolagus cuniculus | D-glucuronic acid + NADP+ | - |
r | |
| L-sorbose + NADPH + H+ | - |
Sus scrofa | ? + NADP+ | - |
r | |
| L-xylose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| m-nitrobenzaldehyde + NADPH | - |
Sus scrofa | m-nitrobenzylalcohol + NADP+ | - |
r | |
| methylglyoxal + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
r | |
| methylglyoxal + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
| n-butanol + NADP+ | - |
Sus scrofa | butyraldehyde + NADPH | - |
r | |
| n-butyraldehyde + NADPH | relative activity 2% | Sus scrofa | n-butanol + NADP+ | - |
r | |
| o-nitrobenzaldehyde + NADPH | - |
Sus scrofa | o-nitrobenzylalcohol + NADP+ | - |
r | |
| p-carboxybenzaldehyde + NADPH | - |
Rattus norvegicus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
| p-carboxybenzaldehyde + NADPH | - |
Sus scrofa | p-carboxybenzyl alcohol + NADP+ | - |
r | |
| p-carboxybenzaldehyde + NADPH | - |
Bos taurus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
| p-chlorobenzaldehyde + NADPH + H+ | - |
Sus scrofa | p-chlorobenzyl alcohol + NADP+ | - |
r | |
| p-cyanobenzaldehyde + NADPH | - |
Sus scrofa | p-cyanobenzyl alcohol + NADP+ | - |
? | |
| p-cyanobenzaldehyde + NADPH | - |
Bos taurus | p-cyanobenzyl alcohol + NADP+ | - |
? | |
| p-fluorobenzaldehyde + NADPH + H+ | - |
Sus scrofa | p-fluorobenzyl alcohol + NADP+ | - |
? | |
| p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Sus scrofa | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Oryctolagus cuniculus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| propiophenone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| pyridoxal + NADPH | - |
Sus scrofa | 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol + NADP+ | - |
? | |
| pyruvaldehyde + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| pyruvate + NADPH | - |
Sus scrofa | 2-hydroxypropanoic acid + NADP+ | - |
? | |
| Tris + NADP+ | - |
Sus scrofa | ? + NADPH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Rattus norvegicus |
| monomer | - |
Bos taurus |
| monomer | 1 * 38000, SDS-PAGE | Sus scrofa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bovine brain aldehyde reductase | - |
Bos taurus |
| rabbit kidney aldehyde-ketone reductase | - |
Oryctolagus cuniculus |
| TPNH-linked aldehyde reductase | - |
Sus scrofa |
| TPNH-specific aldehyde reductase | - |
Sus scrofa |
| triphosphopyridine nucleotide-linked aldehyde reductase | - |
Sus scrofa |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
3-Pyridinemethanol | - |
Sus scrofa | |
| 0.612 | - |
glycerol | - |
Sus scrofa | |
| 1.77 | - |
L-arabitol | - |
Sus scrofa | |
| 5.6 | - |
(+)-Camphorquinone | - |
Sus scrofa | |
| 11.6 | - |
D-glucuronate | - |
Sus scrofa | |
| 13.7 | - |
D-Lactaldehyde | - |
Sus scrofa | |
| 14.4 | - |
D-glyceraldehyde | - |
Sus scrofa | |
| 16.6 | - |
4-cyanobenzaldehyde | - |
Sus scrofa | |
| 19.3 | - |
4-Pyridinecarboxaldehyde | - |
Sus scrofa | |
| 21.7 | - |
4-carboxybenzaldehyde | - |
Sus scrofa | |
| 22 | - |
4-nitrobenzaldehyde | - |
Sus scrofa | |
| 26.8 | - |
3-Pyridinecarboxaldehyde | - |
Sus scrofa | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Bos taurus |
| 7 | - |
reduction of 3-pyridinecarboxaldehyde | Sus scrofa |
| 10 | - |
oxidation of 3-pyridinemethanol | Sus scrofa |
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