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Literature summary for 1.1.1.2 extracted from

  • Weckbecker, A.; Hummel, W.
    Improved synthesis of chiral alcohols with Escherichia coli cells co-expressing pyridine nucleotide transhydrogenase, NADP(+)-dependent alcohol dehydrogenase and NAD(+)-dependent formate dehydrogenase (2004), Biotechnol. Lett., 26, 1739-1744.
    View publication on PubMed

Application

Application Comment Organism
synthesis conversion of prochiral ketones to chiral alcohols by Escherichia coli coexpressing enzyme with NAD+-dependent formate dehydrogenase and pyridine nucleotide transhydrogenase genes pnta and pntb, conversion of 66% acetophenone to (R)-phenylethanol over 12 h Lentilactobacillus kefiri

Organism

Organism UniProt Comment Textmining
Lentilactobacillus kefiri
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recombinant enzyme expressed in Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetophenone + NADPH + H+ catalysed by Escherichia coli coexpressing enzyme with NAD+-dependent formate dehydrogenase and pyridine nucleotide transhydrogenase genes pnta and pntb Lentilactobacillus kefiri (R)-1-phenylethanol + NADP+
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