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EC 3.4.24.88 Details
show Brenda entryEC number
3.4.24.88
Accepted name
desampylase
Reaction
an N6-[small archaeal modifier protein]-[protein]-L-lysine + H2O = a [protein]-L-lysine + a small archaeal modifier protein
Other name(s)
SAMP-protein conjugate cleaving protease,
HvJAMM1
Systematic name
N6-[small archaeal modifier protein]-[protein]-L-lysine hydrolase
Comment
The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67.
History
created 2015, deleted 2016
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1 Oxidoreductases
3 Hydrolases
3.4.24.2 created 1972, deleted 1992 3.4.24.4 created 1972 [EC 3.4.99.13 and EC 3.4.99.22 both created 1972, incorporated 1978], deleted 1992 3.4.24.5 created 1978, deleted 1989 3.4.24.8 created 1978, deleted 1992 3.4.24.9 created 1978, deleted 1992
