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EC 3.4.24.13 Details
EC number
3.4.24.13
Accepted name
IgA-specific metalloendopeptidase
Reaction
Cleavage of Pro┼Thr bond in the hinge region of the heavy chain of human IgA
Other name(s)
immunoglobulin A1 proteinase,
IgA protease,
IgA1-specific proteinase,
IgA1 protease,
IgA1 proteinase
CAS registry number
72231-73-3
Comment
A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase)
History
created 1984
EC Tree
3.4.24.2 created 1972, deleted 1992
3.4.24.4 created 1972 [EC 3.4.99.13 and EC 3.4.99.22 both created 1972, incorporated 1978], deleted 1992
3.4.24.5 created 1978, deleted 1989
3.4.24.8 created 1978, deleted 1992
3.4.24.9 created 1978, deleted 1992
3.4.24.10 created 1972 as EC 3.4.99.12, transferred 1978 to EC 3.4.24.10, deleted 1992