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EC 3.4.24.82 Details
EC number
3.4.24.82
Accepted name
ADAMTS-4 endopeptidase
Reaction
Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373┼Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan
Other name(s)
aggrecanase-1
CAS registry number
147172-61-0
Comment
In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.
History
created 2003
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.4.1 α-Amino-acyl-peptide hydrolases (deleted sub-subclass)
3.4.2 Peptidyl-amino-acid hydrolases (deleted sub-subclass)
3.4.3 Dipeptide hydrolases (deleted sub-subclass)
3.4.4 Peptidyl peptide hydrolases (deleted sub-subclass)
3.4.11 Aminopeptidases
3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)
3.4.13 Dipeptidases
3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
3.4.15 Peptidyl-dipeptidases
3.4.16 Serine-type carboxypeptidases
3.4.17 Metallocarboxypeptidases
3.4.18 Cysteine-type carboxypeptidases
3.4.19 Omega peptidases
3.4.21 Serine endopeptidases
3.4.22 Cysteine endopeptidases
3.4.23 Aspartic endopeptidases
3.4.24 Metalloendopeptidases
3.4.24.1 atrolysin A
3.4.24.2 created 1972, deleted 1992
3.4.24.3 microbial collagenase
3.4.24.4 created 1972 [EC 3.4.99.13 and EC 3.4.99.22 both created 1972, incorporated 1978], deleted 1992
3.4.24.5 created 1978, deleted 1989
3.4.24.6 leucolysin
3.4.24.7 interstitial collagenase
3.4.24.8 created 1978, deleted 1992
3.4.24.9 created 1978, deleted 1992
3.4.24.10 created 1972 as EC 3.4.99.12, transferred 1978 to EC 3.4.24.10, deleted 1992
3.4.24.11 neprilysin
3.4.24.12 envelysin
3.4.24.13 IgA-specific metalloendopeptidase
3.4.24.14 procollagen N-endopeptidase
3.4.24.15 thimet oligopeptidase
3.4.24.16 neurolysin
3.4.24.17 stromelysin 1
3.4.24.18 meprin A
3.4.24.19 procollagen C-endopeptidase
3.4.24.20 peptidyl-Lys metalloendopeptidase
3.4.24.21 astacin
3.4.24.22 stromelysin 2
3.4.24.23 matrilysin
3.4.24.24 gelatinase A
3.4.24.25 vibriolysin
3.4.24.26 pseudolysin
3.4.24.27 thermolysin
3.4.24.28 bacillolysin
3.4.24.29 aureolysin
3.4.24.30 coccolysin
3.4.24.31 mycolysin
3.4.24.32 β-lytic metalloendopeptidase
3.4.24.33 peptidyl-Asp metalloendopeptidase
3.4.24.34 neutrophil collagenase
3.4.24.35 gelatinase B
3.4.24.36 leishmanolysin
3.4.24.37 saccharolysin
3.4.24.38 gametolysin
3.4.24.39 deuterolysin
3.4.24.40 serralysin
3.4.24.41 atrolysin B
3.4.24.42 atrolysin C
3.4.24.43 atroxase
3.4.24.44 atrolysin E
3.4.24.45 atrolysin F
3.4.24.46 adamalysin
3.4.24.47 horrilysin
3.4.24.48 ruberlysin
3.4.24.49 bothropasin
3.4.24.50 bothrolysin
3.4.24.51 ophiolysin
3.4.24.52 trimerelysin I
3.4.24.53 trimerelysin II
3.4.24.54 mucrolysin
3.4.24.55 pitrilysin
3.4.24.56 insulysin
3.4.24.57 O-sialoglycoprotein endopeptidase
3.4.24.58 russellysin
3.4.24.59 mitochondrial intermediate peptidase
3.4.24.60 dactylysin
3.4.24.61 nardilysin
3.4.24.62 magnolysin
3.4.24.63 meprin B
3.4.24.64 mitochondrial processing peptidase
3.4.24.65 macrophage elastase
3.4.24.66 choriolysin L
3.4.24.67 choriolysin H
3.4.24.68 tentoxilysin
3.4.24.69 bontoxilysin
3.4.24.70 oligopeptidase A
3.4.24.71 endothelin-converting enzyme 1
3.4.24.72 fibrolase
3.4.24.73 jararhagin
3.4.24.74 fragilysin
3.4.24.75 lysostaphin
3.4.24.76 flavastacin
3.4.24.77 snapalysin
3.4.24.78 gpr endopeptidase
3.4.24.79 pappalysin-1
3.4.24.80 membrane-type matrix metalloproteinase-1
3.4.24.81 ADAM10 endopeptidase
3.4.24.82 ADAMTS-4 endopeptidase
3.4.24.83 anthrax lethal factor endopeptidase
3.4.24.84 Ste24 endopeptidase
3.4.24.85 S2P endopeptidase
3.4.24.86 ADAM 17 endopeptidase
3.4.24.87 ADAMTS13 endopeptidase
3.4.24.88 desampylase
3.4.24.89 Pro-Pro endopeptidase
3.4.25 Threonine endopeptidases
3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases