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EC 3.4.24.58 Details
EC number
3.4.24.58
Accepted name
russellysin
Reaction
Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg┼ bonds. Has no action on insulin B chain
Other name(s)
Russell's viper venom factor X activator,
RVV-X,
blood-coagulation factor X activating enzyme,
metalloproteinase RVV-x,
Vipera russelli proteinase,
Russell's viper blood coagulation factor X activator,
RVV-V
CAS registry number
79393-92-3
Comment
This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family)
History
created 1993
EC Tree
3.4.24.2 created 1972, deleted 1992
3.4.24.4 created 1972 [EC 3.4.99.13 and EC 3.4.99.22 both created 1972, incorporated 1978], deleted 1992
3.4.24.5 created 1978, deleted 1989
3.4.24.8 created 1978, deleted 1992
3.4.24.9 created 1978, deleted 1992
3.4.24.10 created 1972 as EC 3.4.99.12, transferred 1978 to EC 3.4.24.10, deleted 1992