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EC 3.4.24.60 Details
EC number
3.4.24.60
Accepted name
dactylysin
Reaction
Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1′ position. Shows a preference for hydrophobic doublets such as -Phe┼Phe- and -Phe┼Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively
Other name(s)
peptide hormone inactivating endopeptidase, PHIE
CAS registry number
139466-40-3
Comment
An endopeptidase of 100 kDa secreted from the skin of the amphibian, Xenopus laevis (Dactylêtre du Cap). Resembles neprilysin in insensitivity to 1 μM captopril, but differs from it in being insensitive to thiorphan (1 μM) and unable to digest [Met5]enkephalin, [Leu5]enkephalin, oxytocin, and substance P-(7-11)-peptide. A similar endopeptidase is found in human neuroblastoma cells [2]
History
created 1995
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.4.1 α-Amino-acyl-peptide hydrolases (deleted sub-subclass)
3.4.2 Peptidyl-amino-acid hydrolases (deleted sub-subclass)
3.4.3 Dipeptide hydrolases (deleted sub-subclass)
3.4.4 Peptidyl peptide hydrolases (deleted sub-subclass)
3.4.11 Aminopeptidases
3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)
3.4.13 Dipeptidases
3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
3.4.15 Peptidyl-dipeptidases
3.4.16 Serine-type carboxypeptidases
3.4.17 Metallocarboxypeptidases
3.4.18 Cysteine-type carboxypeptidases
3.4.19 Omega peptidases
3.4.21 Serine endopeptidases
3.4.22 Cysteine endopeptidases
3.4.23 Aspartic endopeptidases
3.4.24 Metalloendopeptidases
3.4.24.1 atrolysin A
3.4.24.2 created 1972, deleted 1992
3.4.24.3 microbial collagenase
3.4.24.4 created 1972 [EC 3.4.99.13 and EC 3.4.99.22 both created 1972, incorporated 1978], deleted 1992
3.4.24.5 created 1978, deleted 1989
3.4.24.6 leucolysin
3.4.24.7 interstitial collagenase
3.4.24.8 created 1978, deleted 1992
3.4.24.9 created 1978, deleted 1992
3.4.24.10 created 1972 as EC 3.4.99.12, transferred 1978 to EC 3.4.24.10, deleted 1992
3.4.24.11 neprilysin
3.4.24.12 envelysin
3.4.24.13 IgA-specific metalloendopeptidase
3.4.24.14 procollagen N-endopeptidase
3.4.24.15 thimet oligopeptidase
3.4.24.16 neurolysin
3.4.24.17 stromelysin 1
3.4.24.18 meprin A
3.4.24.19 procollagen C-endopeptidase
3.4.24.20 peptidyl-Lys metalloendopeptidase
3.4.24.21 astacin
3.4.24.22 stromelysin 2
3.4.24.23 matrilysin
3.4.24.24 gelatinase A
3.4.24.25 vibriolysin
3.4.24.26 pseudolysin
3.4.24.27 thermolysin
3.4.24.28 bacillolysin
3.4.24.29 aureolysin
3.4.24.30 coccolysin
3.4.24.31 mycolysin
3.4.24.32 β-lytic metalloendopeptidase
3.4.24.33 peptidyl-Asp metalloendopeptidase
3.4.24.34 neutrophil collagenase
3.4.24.35 gelatinase B
3.4.24.36 leishmanolysin
3.4.24.37 saccharolysin
3.4.24.38 gametolysin
3.4.24.39 deuterolysin
3.4.24.40 serralysin
3.4.24.41 atrolysin B
3.4.24.42 atrolysin C
3.4.24.43 atroxase
3.4.24.44 atrolysin E
3.4.24.45 atrolysin F
3.4.24.46 adamalysin
3.4.24.47 horrilysin
3.4.24.48 ruberlysin
3.4.24.49 bothropasin
3.4.24.50 bothrolysin
3.4.24.51 ophiolysin
3.4.24.52 trimerelysin I
3.4.24.53 trimerelysin II
3.4.24.54 mucrolysin
3.4.24.55 pitrilysin
3.4.24.56 insulysin
3.4.24.57 O-sialoglycoprotein endopeptidase
3.4.24.58 russellysin
3.4.24.59 mitochondrial intermediate peptidase
3.4.24.60 dactylysin
3.4.24.61 nardilysin
3.4.24.62 magnolysin
3.4.24.63 meprin B
3.4.24.64 mitochondrial processing peptidase
3.4.24.65 macrophage elastase
3.4.24.66 choriolysin L
3.4.24.67 choriolysin H
3.4.24.68 tentoxilysin
3.4.24.69 bontoxilysin
3.4.24.70 oligopeptidase A
3.4.24.71 endothelin-converting enzyme 1
3.4.24.72 fibrolase
3.4.24.73 jararhagin
3.4.24.74 fragilysin
3.4.24.75 lysostaphin
3.4.24.76 flavastacin
3.4.24.77 snapalysin
3.4.24.78 gpr endopeptidase
3.4.24.79 pappalysin-1
3.4.24.80 membrane-type matrix metalloproteinase-1
3.4.24.81 ADAM10 endopeptidase
3.4.24.82 ADAMTS-4 endopeptidase
3.4.24.83 anthrax lethal factor endopeptidase
3.4.24.84 Ste24 endopeptidase
3.4.24.85 S2P endopeptidase
3.4.24.86 ADAM 17 endopeptidase
3.4.24.87 ADAMTS13 endopeptidase
3.4.24.88 desampylase
3.4.24.89 Pro-Pro endopeptidase
3.4.25 Threonine endopeptidases
3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases