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2.7.7.1: nicotinamide-nucleotide adenylyltransferase

This is an abbreviated version!
For detailed information about nicotinamide-nucleotide adenylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.1

Reaction

ATP
+
nicotinamide ribonucleotide
=
diphosphate
 +
NAD+

Synonyms

adenosine triphosphate-nicotinamide mononucleotide transadenylase, adenylyltransferase, nicotinamide mononucleotide, Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase, AtNMNAT, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, Drosophila NMNAT, GlNMNAT, hNMNAT, hNMNAT-1, hNMNAT-2, human nicotinamide mononucleotide adenylyl-transferase, m-nonN-Nmnat1, mononucleotide adenylyltransferase, More, NAD synthase, NAD+ pyrophosphorylase, nadD, NadM-Nudix, NadR, NaMNAT, nicotinamide 5'-mononucleotide adenylyltransferase, nicotinamide 5'-mononucleotide adenylyltransferase-2, nicotinamide 5-mononucleotide adenylyltransferase-2, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyl-transferase, nicotinamide mononucleotide adenylyltransferase, nicotinamide mononucleotide adenylyltransferase 1, nicotinamide mononucleotide adenylyltransferase 2, nicotinamide mononucleotide adenylyltransferase type 1, nicotinamide mononucleotide adenylyltransferase1, nicotinamide mononucleotide adenylyltransferase2, nicotinamide/nicotinate mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, nicotinate/nicotinamide mononucleotide adenyltransferase, NMN adenylyl transferase 1, NMN adenylyltransferase, NMN adenylyltransferase/ADP-ribose pyrophosphatase, NMN AT, NMN-adenylyltransferase, NMN/NaMN adenylyltransferase, NMN/NaMN adenylyltransferase 2, NMN/NaMN adenylyltransferase 3, NMNAT, NMNAT-2, NMNAT1, NMNAT2, NMNAT3, NMNATase, non-nuclear-localized-Nmnat1, PF3D7_1327600, PNAT, Pof1, pyridine nucleotide adenylyltransferase, Tc00.1047053507047.170, TK0067, TTHA1780, yNMNAT-1, yNMNAT-2

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.1 nicotinamide-nucleotide adenylyltransferase

Expression

Expression on EC 2.7.7.1 - nicotinamide-nucleotide adenylyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of POF1 is slightly induced in the late log phase
isoform Nmnat2 protein levels increase dramatically upon differentiation of SH-SY5Y cells
-
NMNAT-2 expression is induced upon DNA damage in a p53-dependent manner. Two putative p53 binding sites are identified within the human NMNAT-2 gene, and both are functional in a p53-dependent manner, overview. DNA damage agents, actinomycin D and doxorubicin, and Nutlin-3a, a p53 stabilizer that disrupts interaction of p53 with its negative regulator MDM2, in a time-dependent manner in control but not in p53-knockdown U2-OS cells
NMNAT1 expression is induced by DNA damage
under hypoxia, hypoxia-inducible factor 1alpha up-regulates the enzyme indirectly through the induction of heat shock factor. Acute exposure to hypoxia (5% O2) for 3 h results in a 3.1fold up-regulation in enzyme transcript level. Heat shock at 37°C induces a 3fold increase in protein level between 8 and 12 h post-heat shock and a 3fold increase in enzyme transcript level at 3 h post-heat shock. A 3.3fold increase of protein level is seen in flies fed with 20 mM paraquat for 72 h
-