2.7.7.1: nicotinamide-nucleotide adenylyltransferase

This is an abbreviated version!
For detailed information about nicotinamide-nucleotide adenylyltransferase, go to the full flat file.

Reaction

Synonyms

adenosine triphosphate-nicotinamide mononucleotide transadenylase, adenylyltransferase, nicotinamide mononucleotide, Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase, AtNMNAT, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, Drosophila NMNAT, GlNMNAT, hNMNAT, hNMNAT-1, hNMNAT-2, human nicotinamide mononucleotide adenylyl-transferase, m-nonN-Nmnat1, mononucleotide adenylyltransferase, More, NAD synthase, NAD+ pyrophosphorylase, nadD, NadM-Nudix, NadR, NaMNAT, nicotinamide 5'-mononucleotide adenylyltransferase, nicotinamide 5'-mononucleotide adenylyltransferase-2, nicotinamide 5-mononucleotide adenylyltransferase-2, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyl-transferase, nicotinamide mononucleotide adenylyltransferase, nicotinamide mononucleotide adenylyltransferase 1, nicotinamide mononucleotide adenylyltransferase 2, nicotinamide mononucleotide adenylyltransferase type 1, nicotinamide mononucleotide adenylyltransferase1, nicotinamide mononucleotide adenylyltransferase2, nicotinamide/nicotinate mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, nicotinate/nicotinamide mononucleotide adenyltransferase, NMN adenylyl transferase 1, NMN adenylyltransferase, NMN adenylyltransferase/ADP-ribose pyrophosphatase, NMN AT, NMN-adenylyltransferase, NMN/NaMN adenylyltransferase, NMN/NaMN adenylyltransferase 2, NMN/NaMN adenylyltransferase 3, NMNAT, NMNAT-2, NMNAT1, NMNAT2, NMNAT3, NMNATase, non-nuclear-localized-Nmnat1, PF3D7_1327600, PNAT, Pof1, pyridine nucleotide adenylyltransferase, Tc00.1047053507047.170, TK0067, TTHA1780, yNMNAT-1, yNMNAT-2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.1 nicotinamide-nucleotide adenylyltransferase

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Results	in table
9	Activating Compound
8551	AA Sequence
10	Application
1	CAS Registry Number
39	Cloned(Commentary)
21	Crystallization (Commentary)
404	Disease/ Diagnostics
6	Expression
53	General Information
13	General Stability
11	IC50 Value
57	Inhibitors
27	kcat/KM [mM/s]
66	Ki Value [mM]
213	KM Value [mM]
51	Localization
86	Metals/Ions
60	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
368	Organism
6	Pathway
67	PDB ID
25	pH Optimum
2	pH Range
3	pH Stability
13	pI Value
12	Posttranslational Modification
42	Protein Variants
50	Purification (Commentary)
6	Reaction
11	Reaction Type
144	Reference
136	Source Tissue
31	Specific Activity [micromol/min/mg]
24	Storage Stability
297	Substrates and Products (Substrate)
61	Subunits
194	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
4	Temperature Range [°C]
20	Temperature Stability [°C]
57	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.7.7.1 - nicotinamide-nucleotide adenylyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ADP + nicotinamide ribonucleotide

NAD+ + phosphate

2 entries

AMP + nicotinamide ribonucleotide

NAD+

2 entries

ATP + 3-acetylpyridine-NAD+

?

2 entries

ATP + 3-pyridinealdehyde-NAD+

?

2 entries

ATP + beta-NMNH

diphosphate + ?

Bos taurus

-

-

642792

-

-

r

ATP + nicotinamide mononucleotide

diphosphate + NAD+

2 entries

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

117 entries

ATP + nicotinate D-ribonucleotide

diphosphate + deamino-NAD+

Katsuwonus pelamis

-

-

642791

-

-

?

ATP + nicotinate D-ribonucleotide

diphosphate + nicotinate adenine dinucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

672248

i.e. nicotinic acid adenine dinucleotide

-

?

ATP + nicotinate mononucleotide

diphosphate + nicotinate adenine dinucleotide

Arabidopsis thaliana

-

-

722873

-

-

?

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

21 entries

ATP + nicotinic acid mononucleotide

diphosphate + deamido-NAD+

3 entries

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

9 entries

ATP + NMN

diphosphate + NAD+

6 entries

ATP + NMNH

diphosphate + NADH

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

672248

-

-

?

ATP + tiazofurin

diphosphate + thiazole-4-carboxamide adenine dinucleotide

Homo sapiens

Q9BZQ4

tiazofurin is a pro-drug that is metabolized by cytosolic nicotinamide mononucleotide adenylyltransferase2

737971

-

-

?

ATP + tiazofurin 5'-monophosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2

672248

-

-

?

ATP + tiazofurin monophosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2

672248

-

-

?

CTP + nicotinamide ribonucleotide

diphosphate + nicotinamide cytosine dinucleotide

Saccharomyces cerevisiae

-

isoform yNMNAT-2

661539

-

-

?

dATP + nicotinamide ribonucleotide

diphosphate + ?

Saccharomyces cerevisiae

-

isoform yNMNAT-1

661539

-

-

?

dATP + nicotinamide ribonucleotide

diphosphate + nicotinamide deoxyadenosine dinucleotide

Saccharomyces cerevisiae

-

isoform yNMNAT-2

661539

-

-

?

deoxy-ATP + nicotinamide ribonucleotide

?

3 entries

deoxy-ATP + nicotinate ribonucleotide

?

2 entries

diphosphate + NAD+

ATP + nicotinamide ribonucleotide

2 entries

GTP + nicotinamide ribonucleotide

?

Mus musculus

Q5HZI3, Q99JR6, Q9EPA7

-

723599

-

-

?

GTP + nicotinamide ribonucleotide

diphosphate + NGD+

3 entries

GTP + nicotinamide ribonucleotide

diphosphate + nicotinamide guanine dinucleotide

Saccharomyces cerevisiae

-

isoform yNMNAT-2

661539

-

-

?

GTP + nicotinamide ribonucleotide

nicotineamide guanine dinucleotide + diphosphate

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

only isoenzyme NMNAT3

672248

-

-

?

GTP + NMN

diphosphate + NGD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

substrates of isozyme NMNAT3

672248

i.e. nicotinamide guanosine dinucleotide

-

?

ITP + nicotinamide ribonucleotide

?

Mus musculus

Q5HZI3, Q99JR6, Q9EPA7

-

723599

-

-

?

ITP + nicotinamide ribonucleotide

diphosphate + nicotinamide hypoxanthine dinucleotide

4 entries

ITP + nicotinamide ribonucleotide

nicotinamide hypoxanthine dinucleotide + diphosphate

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

only isoenzyme NMNAT3

672248

-

-

?

ITP + NMN

diphosphate + inosine nicotinamide dinucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

substrates of isozyme NMNAT3

672248

i.e. nicotinamide hypoxanthine dinucleotide

-

?

NADH + diphosphate

?

3 entries

nicotinamide hypoxanthine dinucleotide + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

98% of the activity with NAD+, NMNAT3

662419

-

-

?

nicotinamide hypoxanthine dinucleotide + diphosphate

ITP + nicotinamide ribonucleotide

2 entries

nicotinate mononucleotide + ATP

nicotinate adenine dinucleotide + diphosphate

3 entries

nicotinic acid adenine dinucleotide phosphate + diphosphate

?

3 entries

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

7 entries

NMN + ATP

NAD+ + diphosphate

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

672248

-

-

?

tiazofurin + ATP

tiazofurin adenine dinucleotide + diphosphate

3 entries

tiazofurin monophosphate + ATP

tiazofurin adenine dinucleotide + diphosphate

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

672248

-

-

?

additional information

?

-

26 entries

ADP + nicotinamide ribonucleotide

NAD+ + phosphate

Pyrococcus horikoshii

-

at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 17.5% of the activity with ATP as substrate

745568

-

-

?

ADP + nicotinamide ribonucleotide

NAD+ + phosphate

Pyrococcus horikoshii OT-3

-

at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 17.5% of the activity with ATP as substrate

745568

-

-

?

AMP + nicotinamide ribonucleotide

NAD+

Pyrococcus horikoshii

-

at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 50.6% of the activity with ATP as substrate

745568

-

-

?

AMP + nicotinamide ribonucleotide

NAD+

Pyrococcus horikoshii OT-3

-

at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 50.6% of the activity with ATP as substrate

745568

-

-

?

ATP + 3-acetylpyridine-NAD+

?

Escherichia coli

-

poor substrate

642778

-

-

?

ATP + 3-acetylpyridine-NAD+

?

Saccharomyces cerevisiae

-

reaction at 76% the rate of nicotinamide ribonucleotide

642778

-

-

?

ATP + 3-pyridinealdehyde-NAD+

?

Escherichia coli

-

poor substrate

642778

-

-

?

ATP + 3-pyridinealdehyde-NAD+

?

Saccharomyces cerevisiae

-

reaction at 28% the rate of nicotinamide ribonucleotide

642778

-

-

?

ATP + nicotinamide mononucleotide

diphosphate + NAD+

Thermococcus kodakarensis

Q5JEF8

-

754020

-

-

?

ATP + nicotinamide mononucleotide

diphosphate + NAD+

Thermococcus kodakarensis ATCC BAA-918

Q5JEF8

-

754020

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Anser sp.

-

-

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Anser sp.

-

i.e. NMN or nicotinamide mononucleotide

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Arabidopsis thaliana

-

-

722873

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Arabidopsis thaliana

-

-

703814

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Arabidopsis thaliana

F4K687

Preiss–Handler-independent pathway

676525

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bacillus anthracis

-

-

703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bacillus subtilis

-

-

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bacillus subtilis

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bos taurus

-

-

642792, 642793, 661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bos taurus

-

-

642784

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bos taurus

-

i.e. NMN or nicotinamide mononucleotide

642784, 642792, 642793

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Bos taurus

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

-

-

642778, 703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

P0A752

-

703814

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

-

best substrate

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

-

reverse reaction at 17% the rate of deamido-NAD+-synthesis

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

-

no substrates are deamino-NAD+, NADP+, adenosine diphosphoribose, 3-acetylpyridine-deamino-NAD+, 3-pyridinealdehyde-deamino-NAD+, alpha-isomer of NAD+, ITP, GTP, UTP, CTP, or TTP

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

-

i.e. NMN or nicotinamide mononucleotide

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli

A0A140NE60

very poor substrate for wild-type

760386

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli B / ATCC 11303

-

-

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli B / ATCC 11303

-

best substrate

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli B / ATCC 11303

-

reverse reaction at 17% the rate of deamido-NAD+-synthesis

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli B / ATCC 11303

-

no substrates are deamino-NAD+, NADP+, adenosine diphosphoribose, 3-acetylpyridine-deamino-NAD+, 3-pyridinealdehyde-deamino-NAD+, alpha-isomer of NAD+, ITP, GTP, UTP, CTP, or TTP

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli B / ATCC 11303

-

i.e. NMN or nicotinamide mononucleotide

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Escherichia coli BL21-DE3

A0A140NE60

very poor substrate for wild-type

760386

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Frog

-

-

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Frog

-

i.e. NMN or nicotinamide mononucleotide

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Gadidae

-

-

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Gadidae

-

i.e. NMN or nicotinamide mononucleotide

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Gallus gallus

-

-

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Gallus gallus

-

i.e. NMN or nicotinamide mononucleotide

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Giardia intestinalis

A8BIC5

-

737783

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Haemophilus influenzae

-

-

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Haemophilus influenzae

-

-

703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Haemophilus influenzae

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

-

642794, 642795, 642800, 661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

-

642780, 642781, 703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9HAN9

-

642796, 642797

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

-

642797

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9HAN9

-

642798, 642799

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

-

642799

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

722676

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9HAN9

-

762475

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9BZQ4

-

660960, 722694, 746166, 761048

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

-

761048

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9BZQ4

-

737971

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q96T66

-

703814

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

best substrate

642779

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

strongly stereospecific: beta-, not alpha-anomer of nicotinamide ribonucleotide

642779

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

i.e. NMN or nicotinamide mononucleotide

642779, 642780, 642781, 642794, 642795, 642800

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9HAN9

i.e. NMN or nicotinamide mononucleotide

642796, 642797

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

i.e. NMN or nicotinamide mononucleotide

642797

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q9HAN9

i.e. NMN or nicotinamide mononucleotide

642798, 642799

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

i.e. NMN or nicotinamide mononucleotide

642799

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

key reaction of pyridine nucleotide metabolism

642779

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

central enzyme of NAD biosynthetic pathway

662419

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

NMNAT1

662419

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

NMNAT2

662419

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

NMNAT3

662419

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Katsuwonus pelamis

-

-

642791

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Katsuwonus pelamis

-

i.e. NMN or nicotinamide mononucleotide

642791

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Leishmania braziliensis

-

-

761224

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Leishmania braziliensis

A4H990

-

739581

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Meleagris gallopavo

-

-

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Meleagris gallopavo

-

i.e. NMN or nicotinamide mononucleotide

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanocaldococcus jannaschii

-

-

642800, 661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanocaldococcus jannaschii

Q57961

-

703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanocaldococcus jannaschii

-

i.e. NMN or nicotinamide mononucleotide

642800, 642801, 642810

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanocaldococcus jannaschii

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanocaldococcus jannaschii

Q57961

the enzyme plays a key role in NAD+ biosynthesis

728817

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanocaldococcus jannaschii DSM 2661

Q57961

the enzyme plays a key role in NAD+ biosynthesis

728817

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanothermobacter thermautotrophicus

-

-

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanothermobacter thermautotrophicus

O26253

-

703131, 737353

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanothermobacter thermautotrophicus

-

-

737353

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanothermobacter thermautotrophicus

-

i.e. NMN or nicotinamide mononucleotide

642802, 642803

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanothermobacter thermautotrophicus

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Methanothermobacter thermautotrophicus ATCC 29096

O26253

-

737353

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus

-

-

676185, 722694, 723087, 723592

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus

Q99JR6, Q9EPA7

-

675543

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus

Q99JR6, Q9EPA7

-

705288

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus

Q9EPA7

-

739173

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus

Q5HZI3, Q99JR6, Q9EPA7

-

723599

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus

-

i.e. NMN or nicotinamide mononucleotide

642804

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Mus musculus L1210

-

i.e. NMN or nicotinamide mononucleotide

642804

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

pheasant

-

-

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

pheasant

-

i.e. NMN or nicotinamide mononucleotide

642786

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Plasmodium falciparum

Q8IE38

-

761694

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Pseudomonas aeruginosa

-

-

703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Pyrococcus horikoshii

-

at 70°C, ATP is a prominent donor. However, above 80°C, a relatively small, but significant, NMNAT activity is detected when ATP was replaced by ADP or AMP in the reaction mixture

745568

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Pyrococcus horikoshii OT-3

-

at 70°C, ATP is a prominent donor. However, above 80°C, a relatively small, but significant, NMNAT activity is detected when ATP was replaced by ADP or AMP in the reaction mixture

745568

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Rattus norvegicus

-

-

642784

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Rattus norvegicus

-

i.e. NMN or nicotinamide mononucleotide

642784, 642805

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharolobus solfataricus

-

-

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharolobus solfataricus

-

i.e. NMN or nicotinamide mononucleotide

642801, 642807, 642808, 642809

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharolobus solfataricus

P57084

i.e. NMN or nicotinamide mononucleotide

642810

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharolobus solfataricus

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharolobus solfataricus P2

P57084

i.e. NMN or nicotinamide mononucleotide

642810

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

-

642800

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

-

642778, 642787, 642788, 642789, 642790

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

P53204

-

703814

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

P25576

-

738613

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

best substrate

642778, 642788

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

no substrates are deamino-NAD+, NADP+, adenosine diphosphoribose, 3-acetylpyridine-deamino-NAD+, 3-pyridinealdehyde-deamino-NAD+, alpha-isomer of NAD+, ITP, GTP, UTP, CTP, or TTP

642778

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

i.e. NMN or nicotinamide mononucleotide

642778, 642787, 642788, 642789, 642790, 642800, 642806, 642807

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

final step in biosynthesis of NAD+

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

isoform yNMNAT-1

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae

-

isoform yNMNAT-2

661539

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Saccharomyces cerevisiae BY4742

P25576

-

738613

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Staphylococcus aureus

-

-

703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Sus scrofa

-

-

642781, 642782, 642783, 642784, 642785

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Sus scrofa

-

i.e. NMN or nicotinamide mononucleotide

642781, 642782, 642783, 642784, 642785

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Sus scrofa

-

stereochemistry: catalyses nucleotidyl transfer from adenosine (R)-5'-triphosphate to nicotinamide mononucleotide with inversion of configuration at the alpha-phosphate giving (S)-NAD+

642785

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Synechocystis sp.

-

-

703131

-

-

r

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Thermus thermophilus

Q5SHF0

-

761553

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Trypanosoma cruzi

Q4DPR9

-

738973

-

-

?

ATP + nicotinamide ribonucleotide

diphosphate + NAD+

Trypanosoma cruzi CL Brener

Q4DPR9

-

738973

-

-

?

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Anser sp.

-

i.e. nicotinate mononucleotide

642786

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Bos taurus

-

i.e. nicotinate mononucleotide

642792

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Escherichia coli

-

best substrate

642778

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Escherichia coli

-

i.e. nicotinate mononucleotide

642778

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Frog

-

i.e. nicotinate mononucleotide

642786

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Gadidae

-

i.e. nicotinate mononucleotide

642786

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Gallus gallus

-

i.e. nicotinate mononucleotide

642786

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Homo sapiens

-

i.e. nicotinate mononucleotide

642779, 642780, 642794, 642795

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Homo sapiens

Q9HAN9

i.e. nicotinate mononucleotide

642796, 642797

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Homo sapiens

-

i.e. nicotinate mononucleotide

642797

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Homo sapiens

Q9HAN9

i.e. nicotinate mononucleotide

642798

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Homo sapiens

-

less efficient

642779

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Meleagris gallopavo

-

i.e. nicotinate mononucleotide

642786

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Methanothermobacter thermautotrophicus

-

i.e. nicotinate mononucleotide

642802

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

pheasant

-

i.e. nicotinate mononucleotide

642786

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Saccharolobus solfataricus

-

i.e. nicotinate mononucleotide

642807, 642809

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Saccharolobus solfataricus

P57084

i.e. nicotinate mononucleotide

642810

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Saccharolobus solfataricus P2

P57084

i.e. nicotinate mononucleotide

642810

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Saccharomyces cerevisiae

-

i.e. nicotinate mononucleotide

642778, 642787, 642788, 642807

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Saccharomyces cerevisiae

-

less efficient

642788

-

-

r

ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide

Saccharomyces cerevisiae

-

reaction at 77% the rate of nicotinamide ribonucleotide

642778

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + deamido-NAD+

Mus musculus

Q5HZI3, Q99JR6, Q9EPA7

-

723599

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + deamido-NAD+

Thermococcus kodakarensis

Q5JEF8

-

754020

-

-

?

ATP + nicotinic acid mononucleotide

diphosphate + deamido-NAD+

Thermococcus kodakarensis ATCC BAA-918

Q5JEF8

-

754020

-

-

?

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Bacillus anthracis

-

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Escherichia coli

-

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Haemophilus influenzae

-

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Homo sapiens

-

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Methanocaldococcus jannaschii

Q57961

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Methanothermobacter thermautotrophicus

O26253

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Pseudomonas aeruginosa

-

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Staphylococcus aureus

-

-

703131

-

-

r

ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide

Synechocystis sp.

-

-

703131

-

-

r

ATP + NMN

diphosphate + NAD+

Francisella tularensis

Q5NHR1

the enzyme likely plays a central role in the pathway of NAD de novo synthesis in Francisella tularensis

690090

-

-

?

ATP + NMN

diphosphate + NAD+

Francisella tularensis

Q5NHR1

the enzyme is a bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase, structural aspects of the catalytic mechanism, overview

690090

-

-

?

ATP + NMN

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

672248

-

-

?

ATP + NMN

diphosphate + NAD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

ATP binds before NMN with nuclear isozyme NMNAT1 and Golgi apparatus NMNAT2, but the opposite order is observed with the mitochondrial isozyme NMNAT3

672248

-

-

?

ATP + NMN

diphosphate + NAD+

Synechocystis sp.

Q55928

the enzyme from Synechocystis sp. is primarily involved in NAD savage/recycling pathways

690090

-

-

?

ATP + NMN

diphosphate + NAD+

Synechocystis sp.

Q55928

the enzyme is a bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase, structural aspects of the catalytic mechanism, overview

690090

-

-

?

deoxy-ATP + nicotinamide ribonucleotide

?

Escherichia coli

-

-

642778

-

-

?

deoxy-ATP + nicotinamide ribonucleotide

?

Homo sapiens

Q9HAN9

-

642798

-

-

?

deoxy-ATP + nicotinamide ribonucleotide

?

Saccharomyces cerevisiae

-

-

642778

-

-

?

deoxy-ATP + nicotinate ribonucleotide

?

Escherichia coli

-

reaction at 18% the rate of ATP

642778

-

-

?

deoxy-ATP + nicotinate ribonucleotide

?

Saccharomyces cerevisiae

-

reaction at 30% the rate of ATP

642778

-

-

?

diphosphate + NAD+

ATP + nicotinamide ribonucleotide

Homo sapiens

Q9HAN9

-

762475

-

-

r

diphosphate + NAD+

ATP + nicotinamide ribonucleotide

Leishmania braziliensis

-

-

761224

-

-

r

GTP + nicotinamide ribonucleotide

diphosphate + NGD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

19% of the activity with GTP, reverse reaction with 57% of the activity with NAD+, NMNA3

662419

-

-

r

GTP + nicotinamide ribonucleotide

diphosphate + NGD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

3% of the activity with GTP, reverse reaction with 5% of the activity with NAD+, NMNAT2

662419

-

-

r

GTP + nicotinamide ribonucleotide

diphosphate + NGD+

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

7% of the activity with GTP, reverse reaction with 26% of the activity with NAD+, NMNAT1

662419

-

-

r

ITP + nicotinamide ribonucleotide

diphosphate + nicotinamide hypoxanthine dinucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

27% of the activity with ATP, NMNAT3

662419

-

-

?

ITP + nicotinamide ribonucleotide

diphosphate + nicotinamide hypoxanthine dinucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

5% of the activity with ATP, NMNAT2

662419

-

-

?

ITP + nicotinamide ribonucleotide

diphosphate + nicotinamide hypoxanthine dinucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

6% of the activity with ATP, NMNAT1

662419

-

-

?

ITP + nicotinamide ribonucleotide

diphosphate + nicotinamide hypoxanthine dinucleotide

Saccharomyces cerevisiae

-

isoform yNMNAT-2

661539

-

-

?

NADH + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

53% of the activity with NAD+, NMNAT1

662419

-

-

?

NADH + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

98% of the activity with NAD+, NMNAT2

662419

-

-

?

NADH + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

99% of the activity with NAD+, NMNAT3

662419

-

-

?

nicotinamide hypoxanthine dinucleotide + diphosphate

ITP + nicotinamide ribonucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

37% of the activity with NAD+, NMNAT2

662419

-

-

?

nicotinamide hypoxanthine dinucleotide + diphosphate

ITP + nicotinamide ribonucleotide

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

55% of the activity with NAD+, NMNAT1

662419

-

-

?

nicotinate mononucleotide + ATP

nicotinate adenine dinucleotide + diphosphate

Arabidopsis thaliana

F4K687

Preiss–Handler-dependent pathway

676525

-

-

?

nicotinate mononucleotide + ATP

nicotinate adenine dinucleotide + diphosphate

Escherichia coli

-

-

642778

-

-

?

nicotinate mononucleotide + ATP

nicotinate adenine dinucleotide + diphosphate

Saccharomyces cerevisiae

-

-

642778

-

-

?

nicotinic acid adenine dinucleotide phosphate + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

93% of the activity with NAD+, NMNAT1

662419

-

-

?

nicotinic acid adenine dinucleotide phosphate + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

98% of the activity with NAD+, NMNAT2

662419

-

-

?

nicotinic acid adenine dinucleotide phosphate + diphosphate

?

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

as active as with NAD+, NMNAT3

662419

-

-

?

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Arabidopsis thaliana

-

-

703814

-

-

r

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Escherichia coli

P0A752

-

703814

-

-

r

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Homo sapiens

Q96T66, Q9BZQ4, Q9HAN9

-

672248

-

-

?

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Homo sapiens

Q96T66

activity observed with GTP, ITP

703814

-

-

r

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Mus musculus

-

-

676185

-

-

?

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Mus musculus

Q99JR6, Q9EPA7

-

675543

-

-

?

nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate

Saccharomyces cerevisiae

P53204

activity observed with dATP, ITP

703814

-

-

r

tiazofurin + ATP

tiazofurin adenine dinucleotide + diphosphate

Homo sapiens

-

-

642811

-

-

?

tiazofurin + ATP

tiazofurin adenine dinucleotide + diphosphate

Homo sapiens

Q9HAN9

-

642797

-

-

?

tiazofurin + ATP

tiazofurin adenine dinucleotide + diphosphate

Saccharomyces cerevisiae

-

YLR010W

642811

-

-

?

additional information

?

-

Drosophila melanogaster

-

NAD synthase nicotinamide mononucleotide adenylyltransferase is a stress-response protein that acts as a chaperone for neuronal maintenance and protection

694341

-

-

?

additional information

?

-

Drosophila melanogaster

-

NAD synthase nicotinamide mononucleotide adenylyltransferase displays chaperone function both in biochemical assays and cultured cells. It is upregulated in the brain upon overexpression of poly-glutamine expanded protein and recruited with the chaperone Hsp70 into protein aggregates.

694341

-

-

?

additional information

?

-

Giardia intestinalis

A8BIC5

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18

737783

-

-

?

additional information

?

-

Homo sapiens

Q9BZQ4

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18

737971

-

-

?

additional information

?

-

Homo sapiens

Q9HAN9

isozyme NMNAT1 directly interacts with nucleolar protein nucleomethylin, NML

738586

-

-

?

additional information

?

-

Homo sapiens

-

isozyme NMNAT1 directly interacts with nucleolar protein nucleomethylin, NML

738586

-

-

?

additional information

?

-

Homo sapiens

Q9BZQ4

NMNAT2 complexes with heat shock protein 90 (HSP90)

746166

-

-

?

additional information

?

-

Leishmania braziliensis

-

bifunctional enzyme, additionally catalyzes the reaction with nicotinate ribonucleotide, reaction of EC 2.7.7.18

761224

-

-

-

additional information

?

-

Methanothermobacter thermautotrophicus

O26253

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP

737353

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus

-

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP

737353

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus

O26253

the wild-type enzyme traps a molecule of NADP+ in the active site. This NADP+ molecule is bound in a conformation different from that displayed by NAD+ in the enzyme complex. Binding structure of wild-type and mutant enzymes with NAD+ and NADP+, detailed overview

737353

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus

-

the wild-type enzyme traps a molecule of NADP+ in the active site. This NADP+ molecule is bound in a conformation different from that displayed by NAD+ in the enzyme complex. Binding structure of wild-type and mutant enzymes with NAD+ and NADP+, detailed overview

737353

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus ATCC 29096

O26253

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP

737353

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus ATCC 29096

O26253

the wild-type enzyme traps a molecule of NADP+ in the active site. This NADP+ molecule is bound in a conformation different from that displayed by NAD+ in the enzyme complex. Binding structure of wild-type and mutant enzymes with NAD+ and NADP+, detailed overview

737353

-

-

?

additional information

?

-

Pyrococcus horikoshii

-

the following substrates are inert: GDP, CDP, UDP, IDP, GTP, CTP, ITP, IMP, CMP, TTP, and UTP

745568

-

-

?

additional information

?

-

Pyrococcus horikoshii OT-3

-

the following substrates are inert: GDP, CDP, UDP, IDP, GTP, CTP, ITP, IMP, CMP, TTP, and UTP

745568

-

-

?

additional information

?

-

Saccharomyces cerevisiae

P25576

the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity

738613

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity

738613

-

-

?

additional information

?

-

Saccharomyces cerevisiae BY4742

P25576

the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity

738613

-

-

?

additional information

?

-

Thermus thermophilus

Q5SHF0

no donors: ADP, AMP, TMP, GMP, CMP, UMP and IMP

761553

-

-

-

additional information

?

-

Trypanosoma cruzi

Q4DPR9

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18

738973

-

-

?

additional information

?

-

Trypanosoma cruzi

-

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18

738973

-

-

?

additional information

?

-

Trypanosoma cruzi

Q4DPR9

the enzyme shows activity for both NAMN and NMN, substrates used by NMNAT in the presence of ATP to form NAD+ and NAAD, respectively

738973

-

-

?

additional information

?

-

Trypanosoma cruzi

-

the enzyme shows activity for both NAMN and NMN, substrates used by NMNAT in the presence of ATP to form NAD+ and NAAD, respectively

738973

-

-

?

additional information

?

-

Trypanosoma cruzi CL Brener

Q4DPR9

bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18

738973

-

-

?

additional information

?

-

Trypanosoma cruzi CL Brener

Q4DPR9

the enzyme shows activity for both NAMN and NMN, substrates used by NMNAT in the presence of ATP to form NAD+ and NAAD, respectively

738973

-

-

?