2.7.1.68: 1-phosphatidylinositol-4-phosphate 5-kinase

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For detailed information about 1-phosphatidylinositol-4-phosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.1.68

2.7.1.68

4,5-bisphosphate

phosphoinositide

fracture

pip2

actin

femoral

phospholipase

ptdins4,5p2

phospholipid

cytoskeleton

dislocation

phosphatidylinositol-4,5-bisphosphate

phosphatidic

posterior

gtpases

diacylglycerol

4-kinase

polyphosphoinositides

acetabular

accident

ossification

talin

avascular

rac1

fracture-dislocation

bisphosphate

screw

arf6

5-phosphatase

heterotopic

arthroplasty

3,4,5-trisphosphate

ptdins5p

trochanteric

ovcar-5

osteonecrosis

inositide

osteotomy

kinase-dead

osteochondral

tiazofurin

3hinositol

insps

merle

ptdins3,4,5p3

Reaction

1-phosphatidyl-1D-myo-inositol 4-phosphate

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Synonyms

Diphosphoinositide kinase, More, Mss4, MSS4p, phosphatidylinositol 4,5-biphosphate kinase, phosphatidylinositol 4-phosphate 5-kinase, phosphatidylinositol 4-phosphate 5-kinase 2, phosphatidylinositol 4-phosphate 5-kinase alpha, phosphatidylinositol 4-phosphate 5-kinase beta, phosphatidylinositol 4-phosphate 5-kinase gamma, phosphatidylinositol 4-phosphate 5-kinase gamma661, phosphatidylinositol 4-phosphate 5-kinase Igamma, phosphatidylinositol 4-phosphate 5-kinase Igamma b, phosphatidylinositol 4-phosphate 5-kinase Igamma_i2, phosphatidylinositol 4-phosphate 5-kinase Igamma_v3, phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, phosphatidylinositol 4-phosphate 5-kinase-Ibeta, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol 5-kinase gamma, phosphatidylinositol kinase type I, phosphatidylinositol monophosphate 5-kinase, phosphatidylinositol phosphate 5-kinase, phosphatidylinositol phosphate 5-kinase 1, phosphatidylinositol phosphate 5-kinase 10, phosphatidylinositol phosphate 5-kinase Ibeta, phosphatidylinositol phosphate 5-kinase Igammai2, phosphatidylinositol phosphate kinase type I gamma, phosphatidylinositol-4-phosphate 5' kinase, phosphatidylinositol-4-phosphate 5-kinase, phosphatidylinositol-4-phosphate 5-kinase gamma 635, phosphatidylinositol-4-phosphate 5-kinase1alpha, phosphatidylinositol4-phosphate 5-kinase, phosphoinositol-4-phosphate-5-kinase, PI 4-phosphate 5-kinase, PI(4)P 5-kinase, PI(4)P5-K, PI4P 5-kinase, PI4P5K, PIP kinase, PIP-5kin, PIP5K, PIP5K type I, PIP5K type Ialpha, PIP5K-Ib, PIP5K1, PIP5K1A, PIP5K1alpha, PIP5K1gamma, PIP5K2, PIP5K3, PIP5K9, PIP5Kalpha, PIP5Kbeta, PIP5Kgamma, PIP5Kgamma635, PIP5Kgamma661, PIP5KI, PIP5KI gamma, PIP5KIalpha, PIP5KIbeta, PIP5KIgamma, PIP5KIgamma_i2, PIP5KIgamma_v3, PIP5KIgamma_v6, PIP5Ks, PIPK, PIPK1, PIPK10, PIPK1gamma-87, PIPKalpha, PIPKI, PIPKIalpha, PIPKIgamma, PIPKIgammaI2, PIPKIgammai5, PIPkin, PIPkin Igammab, PIPkinIgamma93, ppk-1, PtdIns(4)P 5-kinase, PtdIns(4)P kinase, PtdIns4P5K, PtdInsP, type 1 phosphatidylinositol-4-phosphate 5-kinase, type I gamma phosphatidylinositol phosphate 5-kinase i5, type I phosphatidylinositol 4-phosphate 5-kinase, type I phosphatidylinositol 4-phosphate 5-kinase gamma, type I phosphatidylinositol phosphate 5-kinase, type I phosphatidylinositol-4-phosphate 5-kinase, type I phosphatidylinositol-4-phosphate 5-kinase alpha, type I phosphatidylinositol-4-phosphate 5-kinase gamma, type I PI 4-phosphate 5-kinase, type I PtdInsP kinase, type Igamma phosphatidylinositol 4-phosphate 5-kinase, type Igamma PIP 5-kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase

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Results	in table
61	Activating Compound
3949	AA Sequence
2	CAS Registry Number
43	Cloned(Commentary)
36	Cofactor
274	Disease/ Diagnostics
3	Expression
48	General Information
1	General Stability
2	IC50 Value
45	Inhibitors
2	Ki Value [mM]
41	KM Value [mM]
80	Localization
47	Metals/Ions
19	Molecular Weight [Da]
82	Natural Substrates/ Products (Substrates)
121	Organism
4	Pathway
6	PDB ID
11	pH Optimum
4	pH Range
1	pI Value
8	Posttranslational Modification
44	Protein Variants
24	Purification (Commentary)
3	Reaction
2	Reaction Type
119	Reference
162	Source Tissue
12	Specific Activity [micromol/min/mg]
5	Storage Stability
162	Substrates and Products (Substrate)
30	Subunits
202	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase

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1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

6 entries

2'(3')-O-(2,4,6-Trinitrophenyl)ATP

competitive

ADP

ATP

above 4 mM

Ca2+

cetyltrimethylammonium bromide

Cutsum

cysteine

1 mM, 49% inhibition

EDTA

slight inhibition between 0.5-5 mM

641773

GSSG

Rattus norvegicus

0.1 mM, 17% inhibition

641822

H2O2

2 entries

heparin

2 entries

ISP-1/myriocin

Saccharomyces cerevisiae

potent inhibitor, 750ng/ml

NEM

1 mM, 26% inhibition

PCMB

0.1 mM, complete inhibition

641822

phosphatidic acid

2 entries

phosphatidylinositol

Schizosaccharomyces pombe

0.1 mM, 125% stimulation

641844

phosphatidylserine

Schizosaccharomyces pombe

0.1 mM, 125% stimulation

641844

quercetin

2 entries

small G proteins ARF

Bos taurus

ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophophatidic acid, but by competitive phosphatidylcholine, proteins ARF1 and ARF3, from brain cytosol, purification and identification, the 21 kDa G-proteins are activated by GTPgammaS, not by GDP, and activate themselves the PI(4)P 5-kinase

660641

sodium deoxycholate

Rattus norvegicus

641773

spermine

Schizosaccharomyces pombe

0.03 mg/ml, 50% inhibition

Trifluoperazine

IC50: about 0.015 mM

Triton X-100

Wortmannin

ZnSO4

Schizosaccharomyces pombe

sensitive to 9 mM ZnSO4

674460

additional information

4 entries