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Literature summary for 2.7.1.68 extracted from

  • Lundberg, G.A.; Jergil, B.; Sundler, R.
    Phosphatidylinositol-4-phosphate kinase from rat brain. Activation by polyamines and inhibition by phosphatidylinositol 4,5-bisphosphate (1986), Eur. J. Biochem., 161, 257-262.
    View publication on PubMed
Search for more literature for 2.7.1.68

Activating Compound

Activating Compound Comment Organism Structure
myelin basic protein enhances activity when phosphatidylinositol 4-phosphate/phosphatidylethanolamine vesicles are used as substrate Rattus norvegicus
spermidine enhances activity Rattus norvegicus
spermine enhances activity severalfold. Causes a shift in the MgCl2 saturation curve from sigmoidal to hyperbolic, lowering the Mg2+ concentration required for optimum kinase activity to the physiological range. 0.6 mM, 4fold increase of phosphorylation activity in phosphatidylinositol/phosphatidylethanolamine vesicles Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ maximal activity at 10 mM MgCl2 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
-
 Rattus norvegicus