2.7.1.68: 1-phosphatidylinositol-4-phosphate 5-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol-4-phosphate 5-kinase, go to the full flat file.

Reaction

Synonyms

Diphosphoinositide kinase, More, Mss4, MSS4p, phosphatidylinositol 4,5-biphosphate kinase, phosphatidylinositol 4-phosphate 5-kinase, phosphatidylinositol 4-phosphate 5-kinase 2, phosphatidylinositol 4-phosphate 5-kinase alpha, phosphatidylinositol 4-phosphate 5-kinase beta, phosphatidylinositol 4-phosphate 5-kinase gamma, phosphatidylinositol 4-phosphate 5-kinase gamma661, phosphatidylinositol 4-phosphate 5-kinase Igamma, phosphatidylinositol 4-phosphate 5-kinase Igamma b, phosphatidylinositol 4-phosphate 5-kinase Igamma_i2, phosphatidylinositol 4-phosphate 5-kinase Igamma_v3, phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, phosphatidylinositol 4-phosphate 5-kinase-Ibeta, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol 5-kinase gamma, phosphatidylinositol kinase type I, phosphatidylinositol monophosphate 5-kinase, phosphatidylinositol phosphate 5-kinase, phosphatidylinositol phosphate 5-kinase 1, phosphatidylinositol phosphate 5-kinase 10, phosphatidylinositol phosphate 5-kinase Ibeta, phosphatidylinositol phosphate 5-kinase Igammai2, phosphatidylinositol phosphate kinase type I gamma, phosphatidylinositol-4-phosphate 5' kinase, phosphatidylinositol-4-phosphate 5-kinase, phosphatidylinositol-4-phosphate 5-kinase gamma 635, phosphatidylinositol-4-phosphate 5-kinase1alpha, phosphatidylinositol4-phosphate 5-kinase, phosphoinositol-4-phosphate-5-kinase, PI 4-phosphate 5-kinase, PI(4)P 5-kinase, PI(4)P5-K, PI4P 5-kinase, PI4P5K, PIP kinase, PIP-5kin, PIP5K, PIP5K type I, PIP5K type Ialpha, PIP5K-Ib, PIP5K1, PIP5K1A, PIP5K1alpha, PIP5K1gamma, PIP5K2, PIP5K3, PIP5K9, PIP5Kalpha, PIP5Kbeta, PIP5Kgamma, PIP5Kgamma635, PIP5Kgamma661, PIP5KI, PIP5KI gamma, PIP5KIalpha, PIP5KIbeta, PIP5KIgamma, PIP5KIgamma_i2, PIP5KIgamma_v3, PIP5KIgamma_v6, PIP5Ks, PIPK, PIPK1, PIPK10, PIPK1gamma-87, PIPKalpha, PIPKI, PIPKIalpha, PIPKIgamma, PIPKIgammaI2, PIPKIgammai5, PIPkin, PIPkin Igammab, PIPkinIgamma93, ppk-1, PtdIns(4)P 5-kinase, PtdIns(4)P kinase, PtdIns4P5K, PtdInsP, type 1 phosphatidylinositol-4-phosphate 5-kinase, type I gamma phosphatidylinositol phosphate 5-kinase i5, type I phosphatidylinositol 4-phosphate 5-kinase, type I phosphatidylinositol 4-phosphate 5-kinase gamma, type I phosphatidylinositol phosphate 5-kinase, type I phosphatidylinositol-4-phosphate 5-kinase, type I phosphatidylinositol-4-phosphate 5-kinase alpha, type I phosphatidylinositol-4-phosphate 5-kinase gamma, type I PI 4-phosphate 5-kinase, type I PtdInsP kinase, type Igamma phosphatidylinositol 4-phosphate 5-kinase, type Igamma PIP 5-kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase

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Results	in table
61	Activating Compound
3949	AA Sequence
2	CAS Registry Number
43	Cloned(Commentary)
36	Cofactor
274	Disease/ Diagnostics
3	Expression
48	General Information
1	General Stability
2	IC50 Value
45	Inhibitors
2	Ki Value [mM]
41	KM Value [mM]
80	Localization
47	Metals/Ions
19	Molecular Weight [Da]
82	Natural Substrates/ Products (Substrates)
121	Organism
4	Pathway
6	PDB ID
11	pH Optimum
4	pH Range
1	pI Value
8	Posttranslational Modification
44	Protein Variants
24	Purification (Commentary)
3	Reaction
2	Reaction Type
119	Reference
162	Source Tissue
12	Specific Activity [micromol/min/mg]
5	Storage Stability
162	Substrates and Products (Substrate)
30	Subunits
202	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

43 entries

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate

Arabidopsis thaliana

O48709

-

689477

PIP5K3 is involved in localizing 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate to the elongating root hair apex and is a key regulator of the machinery that initiates and promotes root hair tip growth.

-

r

additional information

?

-

19 entries

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Arabidopsis thaliana

-

-

739315, 739370, 759964

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Arabidopsis thaliana

Q56YP2, Q9LMN1

-

661757

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Arabidopsis thaliana

-

enzyme is induced by water stress and abscisic acid. The enzyme is involved in water-stress signal transduction

641845

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Bos taurus

-

-

660641

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Bos taurus

-

the product 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly

641842

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Bos taurus

-

the enzyme may be under control of phosphatidic acid level in membranes

641835

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Candida albicans

-

the enzyme is stimulated during temperature-induced morphogenesis, i.e. switch to the hyphal growth form

641851

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Candida albicans

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview

661660

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Entamoeba histolytica

C4LSF7

-

759179

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Entamoeba histolytica HM1:IMSS

C4LSF7

-

759179

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

-

-

721706, 722723, 738090, 738199, 738288, 738599, 738651, 738787, 738790, 738794, 738912, 759168, 759475, 760179

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

Q99755

-

661757, 738659

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

O60331, Q99755

-

759692

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

O60331

-

738106

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

O14986, O60331

-

759537

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

-

-

660641

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

-

Rho-kinase is involved in the Rho-controlled synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate by phosphatidylinositol-4-phosphate 5-kinase

641854

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Homo sapiens

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview

661660

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

-

722784, 723653, 737960, 738165, 739178, 759034

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

O70161, P70181, P70182

-

759416

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

-

660641

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

the activity of the enzyme is regulated by the reversible balance between cAMP-dependent protein kinase-dependent phosphorylation and protein phosphatase 1-dependent dephosphorylation

641855

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

enzyme type 1beta is essential for epidermal growth factor receptor-mediated endocytosis

641846

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

in addition to regulating early steps in endocytosis, the enzyme acts through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to regulate endosomal trafficking and/or fusion

641839

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate

641848

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins

641847

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly

641853

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

the enzyme plays an essential role during neurite retraction in response to a number of diverse stimuli

641856

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking

660875

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview

661660

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, especially produced by isozyme beta, is required for constitutive endocytosis of transferrin receptors via clathrin-coated pits, and probably also for the regulation thereof

662494

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Mus musculus

-

the enzyme activity is regulated by Arf6 activation

662546

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Rattus norvegicus

-

-

660965, 738176

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Rattus norvegicus

-

-

660641

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Rattus norvegicus

-

the enzyme from liver membrane is possible regulated by a G-protein

641831

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Rattus norvegicus

-

the enzyme form PIPKIgamma may cooperate with synaptojanin in the regulation of actin and synaptic vesicle traffic

641852

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Rattus norvegicus

-

type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment

641850

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Saccharomyces cerevisiae

-

enzyme activity is regulated by cAMP levels. This regulation may be critical in the initiation of cell growth for which 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate seems to be necessary

641827

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Saccharomyces cerevisiae

-

the MSS4 gene product functions in regulation of actin-binding proteins through generation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from 1-phosphatidyl-1D-myo-inositol 4-phosphate in or near the plasma membrane

641843

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Saccharomyces cerevisiae

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview

661660

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Schizosaccharomyces pombe

-

the enzyme catalyzes the last step in the synthesis of phosphatidylinositol 4,5-bisphosphate, which is a precursor of diacylglycerol and inositol 1,4,5-triphosphate and is also involved in regulation of actin cytoskeleton remodeling and membrane traffic. The enzyme is regulated by casein kinase Cki1

641844

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Schizosaccharomyces pombe

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview

661660

-

-

?

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Sus scrofa

-

-

721706

-

-

?

additional information

?

-

Arabidopsis thaliana

O48709

GST-PIP5K3 produces 1-phosphatidyl-1D-myo-inositol 4,5 by phosphorylating 1-phosphatidyl-1D-myo-inositol 4-phosphate, both the natural and synthetic forms. Its also phosphorylates 1-phosphatidyl-1D-myo-inositol 5-phosphate, but less efficiently. PIP5K3 catalyzes the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5 preferentially from 1-phosphatidyl-1D-myo-inositol 4-phosphate in vitro.

689477

-

-

?

additional information

?

-

Arabidopsis thaliana

-

GST-PIP5K3 produces 1-phosphatidyl-1D-myo-inositol 4,5 by phosphorylating 1-phosphatidyl-1D-myo-inositol 4-phosphate, both the natural and synthetic forms. Its also phosphorylates 1-phosphatidyl-1D-myo-inositol 5-phosphate, but less efficiently. PIP5K3 catalyzes the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5 preferentially from 1-phosphatidyl-1D-myo-inositol 4-phosphate in vitro.

689477

-

-

?

additional information

?

-

Arabidopsis thaliana

O48709

PIP5K3 may function as a downstream effector of rho-related GTPases of plants (ROPs) in regulatory mechanisms, not only for the planar polarity of bulge initiation but also for the promotion of root hair tip growth.

689477

-

-

?

additional information

?

-

Arabidopsis thaliana

-

PIP5K3 may function as a downstream effector of rho-related GTPases of plants (ROPs) in regulatory mechanisms, not only for the planar polarity of bulge initiation but also for the promotion of root hair tip growth.

689477

-

-

?

additional information

?

-

Arabidopsis thaliana

O48709

Reduced expression of functional PIP5K3 is responsible for the short-root hair phenotype. Inducible overexpression of PIP5K3 enhanced root hair elongation and increased the rate of 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate

689477

-

-

?

additional information

?

-

Arabidopsis thaliana

-

Reduced expression of functional PIP5K3 is responsible for the short-root hair phenotype. Inducible overexpression of PIP5K3 enhanced root hair elongation and increased the rate of 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate

689477

-

-

?

additional information

?

-

Bos taurus

-

ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

660641

-

-

?

additional information

?

-

Candida albicans

-

activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview

661660

-

-

?

additional information

?

-

Homo sapiens

-

ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

660641

-

-

?

additional information

?

-

Homo sapiens

-

subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview

661660

-

-

?

additional information

?

-

Homo sapiens

-

beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization

693097

-

-

?

additional information

?

-

Homo sapiens

-

phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor

693300

-

-

?

additional information

?

-

Mus musculus

-

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview

662546

-

-

?

additional information

?

-

Mus musculus

-

enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

660641

-

-

?

additional information

?

-

Mus musculus

-

subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview

661660

-

-

?

additional information

?

-

Rattus norvegicus

-

ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

660641

-

-

?

additional information

?

-

Rattus norvegicus

-

splicing form a of the isozyme gamma is inactive, splicing form c is involved in maintenance of some neuronal cellular processes

660965

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview

661660

-

-

?

additional information

?

-

Schizosaccharomyces pombe

-

subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview

661660

-

-

?