2.7.1.60: N-acylmannosamine kinase
This is an abbreviated version!
For detailed information about N-acylmannosamine kinase, go to the full flat file.
Word Map on EC 2.7.1.60
-
2.7.1.60
-
sialic
-
myopathy
-
n-acetylneuraminic
-
2.7.1.59
-
sialylation
-
glycoconjugates
-
rimmed
-
n-acetylmannosamine-6-phosphate
-
n-acetyl-d-glucosamine
-
glucokinase
-
nanks
-
aminosugars
-
neu5ac
-
medicine
-
molecular biology
- 2.7.1.60
-
sialic
- myopathy
-
n-acetylneuraminic
-
2.7.1.59
-
sialylation
- glycoconjugates
-
rimmed
-
n-acetylmannosamine-6-phosphate
- n-acetyl-d-glucosamine
- glucokinase
-
nanks
-
aminosugars
- neu5ac
- medicine
- molecular biology
Reaction
Synonyms
acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, acylmannosamine kinase (phosphorylating), ATP:N-acetylmannosamine 6-phosphotransferase, EC 2.7.1.59/EC 2.7.1.60, EC 5.1.3.14/EC 2.7.1.60, GNE, GNE2, GNE3, ManAc kinase, MNK, N-acetylmannosamine kinase, N-acetylmannosamine-6-phosphate 2-epimerase, N-acyl-D-mannosamine kinase, nanK, UDP-GlcNAc 2-epimerase/ManAc kinase, UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase, UDP-GlcNAc-2 epimerase/ManNAc kinase, UDP-GlcNAc-epimerase/ManNAc kinase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase, UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase
ECTree
2.7.1.60 N-acylmannosamine kinaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.1.60 - N-acylmannosamine kinase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
r
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
Staphylococcus aureus PS 47
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
metabolic pathway between hexoses and sialic acids
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
enzyme is involved in sialic acid metabolism
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
enzyme is involved in sialic acid metabolism
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
highly specific for ATP and N-acetyl-D-mannosamine
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
Staphylococcus aureus PS 47
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
highly specific for ATP and N-acetyl-D-mannosamine
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key and rate limiting enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, enzyme mutations can cause hereditary inclusion body myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, mutations in the enzyme causes hereditary inclusion body myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, reduced activity causes distal myopathy with rimmed vacuoles
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
additional information
?
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
isoform GNE2 displays an extended N-terminus compared with isoform GNE, which is linked directly to the epimerase domain. Recombinant GNE2 still possesses both enzymatic activities of GNE
-
-
?
additional information
?
-
isoform GNE3 displays an deleted N-terminus compared with isoform GNE. Recombinant GNE3 shows a total loss of the epimerase activity
-
-
?
additional information
?
-
the enzyme is a bifunctional enzyme uridine diphosphate 1-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, i.e. UDP-GlcNAc 2-epimerase/ManNAc kinase or GNE. The N-terminal domain carries out UDP-GlcNAc epimerase function, whereas the C-terminal domain is responsible for ManNAc kinase activity
-
-
?
additional information
?
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
displays N-acetylglucosamine kinase activity as well as N-acetylmannosamine kinase activity
-
-
?
additional information
?
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
D-glucose, D-mannose, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine are not phosphorylated
-
-
?
additional information
?
-
-
N-acetylglucosamine and N-glycolylglucosamine, N-acetylgalactosamine, mannosamine, glucosamine, galactosamine, mannose, galactose, fructose, glucose, glucose-1-phosphate and glucose-6-phosphate are inactive as substrates, the phosphoryl donor ATP cannot be replaced by GTP, UTP, CTP, TTP, dATP or phosphoenolpyruvate
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
glucose, mannose, fructose, glucosamine, N-acetylglucosamine and N-acetylgalactosamine are inactive as substrates
-
-
?
additional information
?
-
-
no enzyme found when bacteria grow in presence of glucose
-
-
?
