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Literature summary for 2.7.1.60 extracted from

  • Hinderlich, S.; Weidemann, W.; Yardeni, T.; Horstkorte, R.; Huizing, M.
    UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE): A master regulator of sialic acid synthesis (2015), Top. Curr. Chem., 366, 97-138.
No PubMed abstract available
Search for more literature for 2.7.1.60

Protein Variants

Protein Variants Comment Organism
E35X enzyme activity is severely decreased or absent in this mutant Homo sapiens
G135E enzyme activity is severely decreased or absent in this mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-O-methyl-GlcNAc
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acyl-D-mannosamine Homo sapiens
-
 ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y223
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acyl-D-mannosamine
-
 Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
GNE bifunctional enzyme with UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities Homo sapiens
UDP-GlcNAc 2-epimerase/ManNAc kinase
-
 Homo sapiens