2.7.1.60: N-acylmannosamine kinase

This is an abbreviated version!
For detailed information about N-acylmannosamine kinase, go to the full flat file.

Word Map on EC 2.7.1.60

2.7.1.60

sialic

myopathy

n-acetylneuraminic

2.7.1.59

sialylation

glycoconjugates

rimmed

n-acetylmannosamine-6-phosphate

n-acetyl-d-glucosamine

glucokinase

nanks

aminosugars

neu5ac

medicine

molecular biology

Reaction

Synonyms

acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, acylmannosamine kinase (phosphorylating), ATP:N-acetylmannosamine 6-phosphotransferase, EC 2.7.1.59/EC 2.7.1.60, EC 5.1.3.14/EC 2.7.1.60, GNE, GNE2, GNE3, ManAc kinase, MNK, N-acetylmannosamine kinase, N-acetylmannosamine-6-phosphate 2-epimerase, N-acyl-D-mannosamine kinase, nanK, UDP-GlcNAc 2-epimerase/ManAc kinase, UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase, UDP-GlcNAc-2 epimerase/ManNAc kinase, UDP-GlcNAc-epimerase/ManNAc kinase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase, UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.60 N-acylmannosamine kinase

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Results	in table
4	Activating Compound
1936	AA Sequence
3	Application
1	CAS Registry Number
26	Cloned(Commentary)
2	Cofactor
5	Crystallization (Commentary)
28	Disease/ Diagnostics
1	Expression
26	General Information
4	General Stability
24	IC50 Value
39	Inhibitors
7	kcat/KM [mM/s]
1	Ki Value [mM]
21	KM Value [mM]
21	Localization
18	Metals/Ions
23	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
1074	Organism
6	Pathway
17	PDB ID
4	pH Optimum
2	pH Stability
68	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
63	Reference
74	Source Tissue
10	Specific Activity [micromol/min/mg]
6	Storage Stability
99	Substrates and Products (Substrate)
34	Subunits
92	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.1.60 - N-acylmannosamine kinase

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ATP + N-acetyl-D-mannosamine

ADP + N-acetyl-D-mannosamine 6-phosphate

25 entries

ATP + N-acyl-D-mannosamine

ADP + N-acyl-D-mannosamine 6-phosphate

14 entries

additional information

Homo sapiens

Q9Y223

the enzyme is a bifunctional enzyme uridine diphosphate 1-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, i.e. UDP-GlcNAc 2-epimerase/ManNAc kinase or GNE. The N-terminal domain carries out UDP-GlcNAc epimerase function, whereas the C-terminal domain is responsible for ManNAc kinase activity

721653